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Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-06-2014 | Award Amount: 2.99M | Year: 2015

Very preterm birth is a principal determinant of motor and cognitive impairment in later life. About 50 000 infants in the EU survive very preterm birth annually and are at much higher risk of cerebral palsy, visual and auditory deficits, impaired cognitive ability, psychiatric disorders and behavioural problems than infants born at term. However, the long term prognosis at initial discharge from hospital for each individual infant is unknown. Follow-up screening and prevention programmes aim to identify health problems early, enable interventions to improve outcome and to allow optimal management of health care. Despite the recognised importance of these programmes, little is known about their actual application and impact. These programmes consume significant resources because of the multidisciplinary staff required for clinical and developmental assessments and interventions, the coordination required to maintain contact with children after discharge and the time input from families. This project uses a unique resource the EPICE cohort of 6675 babies born before 32 weeks of gestational age and surviving to discharge home in 18 geographically diverse regions in 2011/2012 to assess the impact of these screening programmes on health, care and quality of life for very preterm infants and their families as well as on coverage, ability to meet needs, health equity and costs at the population-level. It will also generate new knowledge about assessment tools and methods. Four inter-related studies will be carried out in 11 EU countries by a multi-disciplinary consortium of clinicians (in obstetrics, paediatrics, and child development), researchers (in epidemiology, health services research and health economics) and a user organisation. Partners have the expertise to implement this project and the national and international renown to translate its result into better programmes and policies.


Moscatelli M.,CNR Institute of Environmental Geology and Geoengineering | Pagliaroli A.,CNR Institute of Environmental Geology and Geoengineering | Mancini M.,CNR Institute of Environmental Geology and Geoengineering | Stigliano F.,CNR Institute of Environmental Geology and Geoengineering | And 4 more authors.
Rendiconti Online Societa Geologica Italiana | Year: 2015

In this note the seismic microzonation of level 1 of the historic center of Rome is presented. After a description of the subsoil model, which is primarily defined in terms of lithotypes and associated shear wave velocities, the results of the ambient noise measurements are presented and the fundamental frequencies are identified in the whole studied area. Finally, the homogeneous microzones in seismic perspective are described, in relation to seismic amplification and slope instability, and compared with damages from seismic events. © Società Geologica Italiana, Roma 2015. Source


In Sicilian Mediterranean ecosystems the European rabbit Oryctolagus cuniculus is a keystone species, very important for popular small game species and for ecological reasons. However, its spread across the island seems to have decreased and fragmented in recent times, but until now no accurate population management has been carried out due to the lack of ethological, ecological and taxonomic knowledge. A biometric analysis of European rabbit specimens from Sicily to widen current taxonomic knowledge was performed. In this paper, 7 body variables and 23 cranial variables of 166 and 120 individuals, respectively, were examined. Thereafter, the results were compared with biometric data from other European populations. The comparison showed that the body size and skull measurement in Sicilian specimens of European rabbit seem to be quite distinct from those given in the literature on rabbit in south-west Spain, whose populations were assigned to Oryctolagus cuniculus algirus subspecies, whereas it was particularly close to the average size of populations in northern Spain and southern France, assigned to Oryctolagus cuniculus cuniculus. Moreover, the Sicilian taxon was not correlated with Bergmann's rule, showing characteristics that could be the result of its introduction, population management or insularity. Biomolecular analyses will be necessary to definitely clarify the taxonomy of European rabbit in Sicily. © WRSA, UPV, 2003. Source


Zorzi M.,Registro Tumori del Veneto | Senore C.,University of Turin | Da Re F.,Settore promozione e sviluppo igiene e sanita pubblica | Barca A.,Regione Lazio | And 11 more authors.
Gut | Year: 2015

Objectives: To assess variation in the main colonoscopy quality indicators in organised colorectal cancer (CRC) screening programmes based on faecal immunochemical test (FIT). Design: Data from a case-series of colonoscopies of FIT-positive subjects were provided by 44 Italian CRC screening programmes. Data on screening history, endoscopic procedure and histology results, and additional information on the endoscopy centre and the endoscopists were collected. The adenoma detection rate (ADR) and caecal intubation rate (CIR) were assessed for the whole population and the individual endoscopists. To explore variation in the quality indicators, multilevel analyses were performed according to patient/centre/endoscopist characteristics. Results: We analysed 75 569 (mean age: 61.3 years; men: 57%) colonoscopies for positive FIT performed by 479 endoscopists in 79 centres. ADR ranged from 13.5% to 75% among endoscopists (mean: 44.8%). ADR was associated with gastroenterology specialty (OR: 0.87 for others, 95% CI 0.76 to 0.96) and, at the endoscopy centre level, with the routine use of sedation (OR: 0.80 if occasional (<33%); 95% CI 0.64 to 1.00) and availability of screening-dedicated sessions (OR: 1.35; 95% CI 1.11 to 1.66). CIR ranged between 58.8% and 100% (mean: 93.1%). Independent predictors of CIR at the endoscopist level were the yearly number of screening colonoscopies performed (OR: 1.51 for endoscopists with >600 colonoscopies; 95% CI 1.11 to 2.04) and, at the endoscopy centre level, screeningdedicated sessions (OR: 2.18; 95% CI 1.24 to 3.83) and higher rates of sedation (OR: 0.47 if occasional; 95% CI 0.24 to 0.92). Conclusions: The quality of colonoscopy was affected by patient-related, endoscopist-related and centre-related characteristics. Policies addressing organisational issues should improve the quality of colonoscopy in our programme and similar programmes. Source


Pace A.,Regina Elena Cancer Institute | Di Lorenzo C.,Don Carlo Gnocchi ONLUS Foundation | Capon A.,Regional Public Health Agency | Villani V.,Regina Elena Cancer Institute | And 7 more authors.
Journal of Palliative Medicine | Year: 2012

Despite aggressive multimodality treatment the prognosis of patients with primary brain tumors (BT) remains poor. At present, there are no data about the role of palliative home-care services and their impact on quality of care. We report the results of a pilot project of palliative home care for BT patients started in 2000 in the National Cancer Institute Regina Elena of Rome. We report also the result of a cost/effectiveness analysis utilizing administrative data on re-hospitalization rate in the last two months of life. Methods: Since October 2000 until December 2009, 572 patients have been followed by our home care staff. Among 394 patients who died, 276 (70%) were followed at home until death. A cost/effectiveness analysis was carried out evaluating the rehospitalization rate in the last 2 months of life in a subgroup of patients (group 1 assisted at home, 72 patients; group 2 not assisted at home, 71). The number of hospital readmission in the last 2 months of life, and length and cost of hospitalization were retrospectively analyzed from hospital discharge records. Results: Hospitalization rate of group 1 (16.7%) was lower than group 2 (38%) (95% CI: 0.18-0.65, p=0.001). Costs of hospitalization also differed substantially: 517 £ (95% CI: 512-522) in represent an alternative to in-hospital care for the management of brain tumor patients and may improve the end-of-life quality of care. © 2012, Mary Ann Liebert, Inc. Source

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