Krasnoyarsk Regional Oncologic Center

Krasnoyarsk, Russia

Krasnoyarsk Regional Oncologic Center

Krasnoyarsk, Russia
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Os'kina N.A.,Russian Academy of Sciences | Boyarskikh U.A.,Russian Academy of Sciences | Lazarev A.F.,Russian Academy of Medical Sciences | Petrova V.D.,Russian Academy of Medical Sciences | And 4 more authors.
Molecular Biology | Year: 2012

Compelling evidence demonstrates the importance of chromosome 8q24 as a locus of susceptibility to prostate cancer. In this work, the association of common 8q24 variants, rs6983267 and rs1447295, with a sporadic risk of prostate cancer was analyzed in the Russian population of Siberia. For this purpose, the above polymorphisms were genotyped in 393 cases and 384 control individuals. The A allele of rs1447295 was significantly associated with prostate cancer risk (OR[CI 95%] = 1.74 [1.26-2.4], p = 7.8 × 10 -4). The common G-A haplotype of rs6983267-rs1447295 also showed association with prostate cancer risk in Russians (OR[CI 95%] = 2.03 [1.1-3.75], p = 0.02). A meta-analysis combining our data with previously published results was performed to better evaluate the association between the SNPs studied and prostate cancer risk; its results strongly supported the association for both loci (p < 10 -6). Thus, our study has confirmed the association of chromosome 8q24 with a risk of prostate cancer. © 2012 Pleiades Publishing, Ltd.


Oskina N.A.,Russian Academy of Sciences | Boyarskikh U.A.,Russian Academy of Sciences | Lazarev A.F.,Russian Academy of Medical Sciences | Petrova V.D.,Russian Academy of Medical Sciences | And 4 more authors.
Urologic Oncology: Seminars and Original Investigations | Year: 2014

Introduction: Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (CaP). However, the risk conferred in men living in Russia is unknown. Materials and methods: In this work we studied the association of rs6983267, rs10090154, and rs1447295 single nucleotide polymorphisms (SNPs) with a risk of CaP development in men of Caucasoid descent living in the Siberian region of Russia. Three 8q24 SNPs were genotyped by real-time polymerase chain reaction in histologically confirmed CaP "cases" (n = 392) and clinically evaluated "controls" (n = 344). To evaluate the SNP effects on CaP susceptibility, odds ratio (OR) and confidence interval (CI) 95% were calculated. Allele and genotype frequencies in the groups were compared using logistic regression; differences were considered statistically significant if P<0.05. Results: We showed statistically significant association of the A allele of rs1447295 (OR [CI 95%] = 1.96 [1.37-2.81], P<0.0001) and the T allele of rs10090154 (OR [CI 95%] = 2.14 [1.41-3.26], P<0.0001) with CaP. The T-A rs10090154 to rs1447295 haplotype was also associated with CaP (OR [CI 95%] = 2.47 [1.59-3.85], P<0.0001). There was no significant association with the T allele of rs6983267: OR [CI 95%] = 0.9 [0.73-1.11], P> 0.05. Conclusion: Thus, our investigation confirms the role of chromosomal region 8q24 in the development of CaP in the Russian population. © 2014 Elsevier Inc.

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