Regional Occupational Health Center Southern

Bangalore, India

Regional Occupational Health Center Southern

Bangalore, India

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Dhananjayan V.,Salim Ali Center for Ornithology and Natural History | Dhananjayan V.,Regional Occupational Health Center Southern
Environmental Science and Pollution Research | Year: 2013

As part of a large study on assessing the impact of environmental contaminants in Indian avifauna, the presence of organochlorine pesticides (OCPs) in liver tissues of 16 species of birds collected from Ahmedabad, India during 2005-2007 was quantified. The higher concentrations of total organochlorine pesticides were detected in livers of shikra Accipiter badius (3. 43 ± 0. 99 μg/g wet wt) and the lower levels in white ibis Pseudibis papillosa (0. 02 ± 0. 01 μg/g wet wt). Marked differences in the concentrations of total OCPs occurred among species (p < 0. 05). Concentrations of DDT and its metabolites, hexachlorocyclohexane (HCH) and isomers, dieldrin, and heptachlor epoxide were lower than the concentrations reported for various species of birds in India. Accumulation pattern of organochlorine pesticides in birds was, in general, in the order HCH > DDT > heptachlor epoxide > dieldrin. Among various pesticides analyzed, p,p′-DDE and β-HCH contributed maximum towards the total OCPs and study indicates the continuous use of lindane and DDT for agriculture and public health purpose, respectively. Although no serious threat is posed by any of the organochlorine pesticides detected in the present study species, continued monitoring is recommended. © 2012 Springer-Verlag Berlin Heidelberg.


Gaikwad A.S.,Regional Occupational Health Center Southern | Karunamoorthy P.,Regional Occupational Health Center Southern | Kondhalkar S.J.,Regional Occupational Health Center Southern | Ambikapathy M.,Regional Occupational Health Center Southern | Beerappa R.,Regional Occupational Health Center Southern
Journal of Occupational Medicine and Toxicology | Year: 2015

Background: Many studies revealed toxic effects of pesticides on pesticide handlers but very fewer studies have been reported among grape garden pesticide sprayers in India. The purpose of this study was to evaluate the effect of pesticides among grape garden sprayers. Methods: 27 pesticide sprayers in study group and 27 non sprayers in control group were recruited. Blood samples were analyzed for hematological profile, biochemical parameters and urine samples for oxidative stress, buccal mucosal cells for genotoxicity. For statistical analysis student's t-test and Mann Whitney U test were used. Results: White blood cell (WBC) count was significantly decreased; uric acid and Malondialdehyde (MDA) level was significantly increased among study group. In present study the Micronucleus (MN) assay for buccal mucosal cell showed significant number of micronucleated cells in study group. Conclusion: These results suggest that pesticide sprayers in grape garden are under risk which need to be monitored continuously in large population and further study is warranted to correlate the pesticide exposure by assessing acetylcholinesterase activity, pesticide residue analysis and their personal habits. © 2015 Gaikwad et al.; licensee BioMed Central.


Dhananjayan V.,Regional Occupational Health Center Southern | Ravichandran B.,Regional Occupational Health Center Southern | Anitha N.,Regional Occupational Health Center Southern | Rajmohan H.,Regional Occupational Health Center Southern
Indian Journal of Occupational and Environmental Medicine | Year: 2012

Background: Cholinesterase determination indicates whether the person has been under pesticide exposure is not. It is recommended that the worker′s cholinesterase level should be assessed for workers at a pesticide applied region. Hence, cholinesterase activities in blood samples of agricultural workers exposed to vegetables and grape cultivation with age matched, unexposed workers, who never had any exposure to pesticides, were estimated. Methods: The detailed occupational history and lifestyle characters were obtained by questionnaire. Cholinesterase activity was determined by the method of Ellman as modified by Chambers and Chambers. Results: AChE was ranging from 1.65 to 3.54μmoles/min/ml in exposed subjects where as it was ranged from 2.22 to 3.51μmoles/min/ml in control subjects. BChE activity was ranging from 0.16 to 5.2μmoles/min/ml among exposed subjects, where as it was ranged from 2.19 to 5.06μmoles/min/ml in control subjects. The results showed statistically significant reduction in enzyme activities (AChE 14%; BChE 56%) among exposed subjects. Conclusion: It was concluded that the reduction in cholinesterase activity may lead to varieties of effects. Hence it is compulsory to use protective gadgets during pesticide spray. Further a continuous biomonitoring study is recommended to assess pesticide exposure.


Dhananjayan V.,Regional Occupational Health Center Southern
Bulletin of Environmental Contamination and Toxicology | Year: 2012

In order to understand whether organochlorine pesticides and polychlorinated biphenyls (PCBs) are responsible for the mortality of waterbirds in Nalaban bird sanctuary in Chilika Lake, the current investigation was carried out in tissues of 11 individuals comprising 7 species of birds. One or more residues were detected in all the tissues of birds analysed. Concentration of ∑HCH, ∑DDT, and ∑PCBs were ranged from below detectable level (BDL)- 811 ng/g, BDL -1,987 ng/g and BDL -1,027 ng/g respectively. PCBs levels were less than the food and drug administration's (FDA) action limits. Although varying levels of residues were detected among tissues, they do not appear to be responsible for the mass mortality of waterfowl. However, the need for additional research is heightened when considering that some of the birds are classified as a globally protected species by the international bodies. © Springer Science+Business Media, LLC 2012.


Dhananjayan V.,Regional Occupational Health Center Southern | Ravichandran B.,Regional Occupational Health Center Southern | Rajmohan H.R.,Regional Occupational Health Center Southern
Bulletin of Environmental Contamination and Toxicology | Year: 2012

To describe exposure level of organochlorine pesticides (OCP) among workers occupationally engaged in agriculture and sheep wool associated jobs, the present study was carried out in rural neighborhood of Bangalore city, India. Thirty participants were interviewed and obtained informed consent before blood sample collection. The maximum concentrations of OCP were detected in blood samples of agriculture workers than sheep wool workers. Among the metabolites of HCH and DDT, lindane (c-HCH) and p,p'-DDE were the most contributed to the total OCP. There were no differences in pesticide residues found between sex and work groups. It was observed that about 30% of samples exceeded the tolerance limits of 10 lg/L prescribed for HCH under the prevention of food adulteration act. Therefore, the present study recommends continuous monitoring with larger sample size. © Springer Science+Business Media, LLC 2012.


Kalahasthi R.B.,Regional Occupational Health Center Southern | Barman T.,Regional Occupational Health Center Southern | Rajmohan H.R.,Regional Occupational Health Center Southern
International Journal of Environmental Health Research | Year: 2014

The present study was carried out to find the relationship between blood lead levels (BLLs) and morbidities among 391 male workers employed in a factory manufacturing lead-acid storage batteries. A predesigned questionnaire was used to collect information on subjective health complaints and clinical observation made during a clinical examination. In addition to monitoring of BLL, other laboratory parameters investigated included hematological and urine-δ-aminolevulinic acid levels. Logistic regression method was used to evaluate the relationship between BLL and morbidities. The BLL among workers was associated with an odd ratio of respiratory, gastrointestinal (GI), and musculoskeletal (MSD) morbidities. Mean corpuscular hemoglobin and packed cell volume variables were associated with respiratory problems. The variables of alcohol consumption and hematological parameters were associated with GI complaints. Systolic blood pressure was related to MSD in workers exposed to Pb during the manufacturing process. © 2013 Taylor & Francis.


Dhananjayan V.,Salim Ali Center for Ornithology and Natural History | Dhananjayan V.,Regional Occupational Health Center Southern
Environmental Science and Pollution Research | Year: 2013

Concentrations of polycyclic aromatic hydrocarbons (PAHs) were measured in liver tissues of seven species of birds collected from Ahmedabad, India during 2005-2007. All the samples collected were dead as victims of kite flying. Concentrations of ∑PAHs in livers of birds were ranged from 110 ± 32. 6 ng/g wet wt (1,078 ± 320 lipid wt) in common myna Acridotheres tristis to 382 ± 90. 1 ng/g (2,388 ± 563 lipid wt) in white-backed vulture. Statistically significant (p < 0. 05) differences in ∑PAHs were observed among species. However, year of collection and sex of birds did not show significant differences in concentrations of PAHs. The levels of ∑PAHs measured in the present study species were higher than the levels documented for a number of avian species and were lower than those reported to have deleterious effects on survival or reproduction of birds. Presence of PAH residues in birds of Ahmedabad city show the continuous input of PAHs through environmental exposure. Although no threat is posed by any of the hydrocarbons detected, continuous monitoring of breeding colonies of birds is recommended in unpolluted reference sites as well as polluted sites. It is also the first account of a comprehensive analysis of PAHs in various species of birds in India. Therefore, the values reported in this study can serve as baseline values for future research. © 2012 Springer-Verlag Berlin Heidelberg.


Barman T.,Regional Occupational Health Center Southern | Kalahasthi R.,Regional Occupational Health Center Southern | Rajmohan H.R.,Regional Occupational Health Center Southern
Journal of Exposure Science and Environmental Epidemiology | Year: 2014

This study was carried out to determin. The effect of Pb exposure o. The status of platelet indices in workers exposed to Pb during lead-acid battery plant process. Platelet indices and blood lead levels (BLLs) were determined in 429 male workers. BLLs were determined by using an atomic absorption spectrophotometer. Platelet indices i. The samples were quantified by usin. The Sysmex KX-21 hematology analyzer. The levels of platelet count (PLT), plateletcrit (PCT) and mean platelet mass (MPM) were significantly decreased and platelet distribution width (PDW), platelet large cell ratio (P-LCR) and mean platelet volume were increased with an increase in BLLs. The results of linear multiple regression analysis showed tha. The platelet count (β-0.143, P=0.005), PCT (β-0.115, P=0.023) and MPM (β-0.110, P=0.030) were negatively associated with BLLs and P-LCR (β 0.122, P=0.016) was positively associated with BLLs. The variable of body mass index showed a positive association with PCT (β 0.105, P=0.032) and MPM (β 0.101, P=0.039). The results o. The study may indicate that lead exposure may impair coagulation function through endothelial tissue injury and reduction of nitric oxide. © 2014 Nature America, Inc. All rights reserved.


Ravibabu K.,Regional Occupational Health Center Southern | Barman T.,Regional Occupational Health Center Southern | Rajmohan H.R.,Regional Occupational Health Center Southern
International Journal of Occupational and Environmental Medicine | Year: 2015

Background: The interaction between serum neuron-specific enolase (NSE), biogenic amino-acids and neurobehavioral function with blood lead levels in workers exposed to lead form lead-acid battery manufacturing process was not studied.Objective: To evaluate serum NSE and biogenic amino-acids (dopamine and serotonin) levels, and neurobehavioral performance among workers exposed to lead from lead-acid storage battery plant, and its relation with blood lead levels (BLLs).Methods: In a cross-sectional study, we performed biochemical and neurobehavioral function tests on 146 workers exposed to lead from lead-acid battery manufacturing process. BLLs were assessed by an atomic absorption spectrophotometer. Serum NSE, dopamine and serotonin were measured by ELISA. Neurobehavioral functions were assessed by CDC-recommended tests-simple reaction time (SRT), symbol digit substitution test (SDST), and serial digit learning test (SDLT).Results: There was a significant correlation (r 0.199, p<0.05) between SDST and BLL. SDLT and SRT had also a significant positive correlation (r 0.238, p<0.01). NSE had a negative correlation (r –0.194, p<0.05) with serotonin level. Multiple linear regression analysis revealed that both SRT and SDST had positive significant associations with BLL. SRT also had a positive significant association with age.Conclusion: Serum NSE cannot be used as a marker for BLL. The only domain of neurobehavioral function tests that is affected by increased BLL in workers of lead-acid battery manufacturing process is that of the “attention and perception” (SDST). © Int J Occup Environ Med. All Rights Reserved.


Saha A.,Regional Occupational Health Center Eastern | Mukherjee A.K.,Regional Occupational Health Center Eastern | Ravichandran B.,Regional Occupational Health Center Southern
Toxicology and Industrial Health | Year: 2016

Frequent and repetitive activities in job and awkward postures are shown as major contributors of musculoskeletal problems in most of the occupational health studies; however, efforts to explore newer risk factor are important to plan interventional measures. In this backdrop, this study examined contribution of fluoride exposure to musculoskeletal complaints. A cross-sectional interviewer-administered questionnaire survey was conducted involving 180 randomly selected subjects from a metal smelting industry. Clinical examination of the subjects was also performed to assess their health status and morbidity details. Assessment of personal exposure to particulate and gaseous fluoride at workplace was conducted. Urinary fluoride level was also examined in post-shift samples collected from study subjects. The mean age of the study subjects was 39.1 (±6.7) years. Majority of the workers (42.5%) were engaged in pot room. About 54% workers were suffering from backache and 66% subjects had joint pain. Exposure of workers to both particulate and gaseous fluoride and post-working shift urinary fluoride level was significantly higher in pot-room workers in comparison with all other workers. It was observed that age (odds ratio (OR): 1.62; 95% confidence interval (CI): 1.18-2.34), drinking untreated water (OR: 1.51; 95% CI: 1.03-2.76), working in pot room (OR: 1.44; 95% CI: 1.13-1.91) and urinary fluoride level (OR: 2.71; 95% CI: 1.81-3.75) had significant effects on musculoskeletal complaints. This study concludes that along with other predictors such as nature of work, posture at work and age of worker, exposure to fluoride also has significant role in the occurrence of musculoskeletal morbidity. © The Author(s) 2015.

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