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Campolmi E.,University of Florence | Mugnai F.,University of Florence | Riccio M.,University of Florence | Grifoni R.,Medical Oncology Unit | And 6 more authors.
Giornale Italiano di Dermatologia e Venereologia

Background: Body image (Bi) is a very important aspect to be taken care of, especially in cancer patients. METHODS: We administered the Body Image Scales, with a speciically created semi-structured questionnaire which includes items that investigate the level of awareness and the degree of acceptance of the disease of the patient, was administered to patients giving their written informed consent to participate to the study. reSUltS: the results show that our population sample got an average score of 17.25 showing precisely problems related to body image. CoNClUSioNS: an adequate psychological support is crucial, as it has been widely demonstrated that body-image-related issues have a negative impact on patients' quality of life, especially in the oncology ield. Such support has the aim of dealing with those aspects which can compromise the patients' equilibrium and quality of life. © 2015 Edizioni Minerva Medica. Source

Lorenzo B.,Regional Melanoma Referral Center | Leonardo P.,Regional Melanoma Referral Center | Carmelo U.,Dermatopathology Section | Paola B.,Regional Melanoma Referral Center | And 5 more authors.
Future Oncology

We report the case of an old woman with an eccrine porocarcinoma unusually localized in the perianal area treated by electrochemotherapy, a new technique, emerging as a very effective local treatment of different skin metastases and selected primary tumors. Electrochemotherapy was performed taking into account patient wishes and refusal of demolitive surgery. The electrochemotherapy treatment was well tolerated by the patient, it gave an excellent clinical response and a complete clinical regression with no sphincter dysfunction and signs of relapse observed during follow-up. The case is of particular interest for the exceptional localization of porocarcinoma for the first time treated by electrochemotherapy in this area. Electrochemotherapy could be considered as an alternative option for selected cases of cutaneous tumors. © 2014 Future Medicine Ltd. Source

Arcangeli A.,University of Florence | Romoli M.R.,University of Florence | Romoli M.R.,Regional Melanoma Referral Center | Boni L.,Clinical Trials Coordinating Center | And 4 more authors.
Melanoma Research

Cutaneous melanoma represents the main cause of death among skin cancers. The thickness of the lesion at diagnosis is one of the most important prognostic indicators for survival, which is good for thin melanomas (≤1 mm) and worsens as thickness increases. Nevertheless, it is not rare to observe disease progression of thin melanomas or, conversely, a good outcome for those melanomas considered to be at high risk, according to the classical prognostic criteria. In the present paper, we analysed for the first time the expression of the hERG1 protein, a potassium channel frequently overexpressed and misexpressed in cancers, in cutaneous melanocytic lesions. The analysis was carried out on archival samples relative to (a) typical melanocytic nevi, (b) atypical melanocytic nevi, (c) thin (<1 mm) melanomas from patients who survived at least 10 years after surgery, (d) thick (>4 mm) melanomas from patients who died for melanoma and (e) melanoma metastases. Samples were analysed by immunohistochemistry using an hERG1-specific antibody. We showed that primary cutaneous melanomas with a thickness greater than 4 mm as well as metastatic melanoma lesions are characterized by a high level of hERG1 expression. Conversely, thin melanomas and benign melanocytic lesions (e.g. typical and atypical melanocytic nevi) express hERG1 at significantly lower levels. Although still preliminary, the data presented here enable us to consider hERG1 as a novel candidate biomarker for aggressive melanoma. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source

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