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Paul S.B.,Assam University | Choudhury S.N.,ICFAI University, Tripura | De B.,Regional Institute of Pharmaceutical Science and Technology
Asian Journal of Chemistry | Year: 2012

The analgesic activity of the methanolic extract of leaves of Neptunia prostrate and its separated fractions were studied in acetic acid induced model. The in vivo antiinflammatory was also studied using Carageenan induced rat paw edema. The result of both the studies indicated that the extract and its components possessed significant analgesic activity as well as antiinflammatory activity at the dose 100 mg/Kg. Both the activities were compared with standard drug aspirin for analgesic and diclofenance sodium for antiinflammatory. The structure of the bioactive compound has been characterized on the basis of spectral data such as IR, 1H NMR, 13C NMR and mass spectral studies.

Choudhury S.N.,ICFAI University, Tripura | De B.,Regional Institute of Pharmaceutical Science and Technology | Paul S.B.,Assam University
Oriental Journal of Chemistry | Year: 2016

Basella rubra is a medicinal plant species found in India and other parts of Asia and tropical Africa. It improves the appetite, useful in biliousness, leprosy, dysentery, ulcers and it has antiviral and antipyretic activity. The red pigment from the fruit has good colouring ability. It is bright purple at pH 3-7. It is a good additive and a safe, non-poisonous colorant. At present, the dyestuff industry has grown rapidly because of the vital role played by small - scale sector, which is responsible for the production of azo, acids, basics and direct dyes. But such synthetic dyes have toxic effect and hence may not be useful in edible substances. Therefore keeping this in mind the structure of two separated compounds from the fruit pigment of medicinally important plant Besella rubra were elucidated. The structures of the compounds have been characterized on the basis of spectral data such as IR, 1H NMR,13C NMR and Mass spectral studies.

De B.,Regional Institute of Pharmaceutical Science and Technology
Journal of Herbal Medicine | Year: 2011

In the last few decades eco-friendly, bio-friendly, cost-effective and relatively safe herbal medicines have moved from the fringe to the mainstream with increased research in the field of traditional medicine. Medicinal plants are an integral component of alternative medical care. For millennia, Indian people traditionally played an important role in the management of biological resources and were custodians of related knowledge that they acquired through trial and error over centuries. India has a rich wealth of medicinal plants and the potential to accept the challenge to meet the global demand for them. Ayurveda, Naturopathy, Unani, Siddha and folk medicine are the major healthcare systems in Indian society, which fully depend upon natural resources. The market for herbal drugs has grown at an impressive rate due to a global resurgence in traditional and alternative healthcare systems, and therefore medicinal plants have great economic importance. However loss of biodiversity, over-exploitation and unscientific use of medicinal plants, industrialization, biopiracy, together with lack of regulation and infrastructure are the major impediments to the growth of herbal medicine. Conservation, proper research based on traditional knowledge, quality control of herbal medicine and proper documentation are essential in the 21st century for the growth of herbal medicine usage. © 2011 Elsevier GmbH. All rights reserved.

Das N.,Regional Institute of Pharmaceutical Science and Technology | Bera T.,Jadavpur University | Mukherjee A.,University of Calcutta
International Journal of Pharma and Bio Sciences | Year: 2012

Biomaterials are biologically compatible materials or formations that can be used to treat, augment or replace tissues in physiological environment. Biomaterials are hybrid structures or may be derived exclusively from synthetic and natural materials. Hydrogels on the other hand are three dimensional crosslinked polymeric networks and can imbibe large amount of water or biological fluids. Hydrogels are extensively used in biomedical areas for a range of unique properties like environment responsiveness, bioadhesive properties, biocompatibility and biodegradability. Biocompatable hydrogels are particularly advantageous in a number of areas like drug delivery, wound management, tissue engineering and organ transplant. This review make an attempt to present a systematic understanding on diverge chemistry and applications of biomaterial hydrogels as applied in pharmaceutical and biomedical arena.

De B.,Regional Institute of Pharmaceutical Science and Technology
Pakistan Journal of Pharmaceutical Sciences | Year: 2014

The present work involved cyclization of Schiff bases to azetidine-2-one and thiazolidine 4-one derivatives. The schiff bases (IIIa-j) were obtained upon reaction between electrophillic carbon atom of furfuraldehyde and nucleophillic nitrogen atom of amines. Azetidine-2-one derivatives (IVa-j) were obtained by reaction between imines and monochloro acetyl chloride in the presence of triethyl amine and 1, 4 dioxan. On the other hand, preparations of thiazolidine-4-ones (Va-j) were preceded by nucleophilic attack of sulphur of thioglycolic acid on imine carbon followed by intramolecular cyclization in the presence of SnCl2. The structures of the compounds were confirmed by spectral and elemental analysis. The biological evaluation of the compounds like anti-microbial, antioxidant, analgesic, CNS depressant and anti-diabetic activity were determined. From the pharmacological investigation it was found that out of all the compounds IVa, IVb, IVe, IVf, IVh, Va, Vb, Ve, Vf, Vh had shown more potent activity. © 2014, Pakistan Journal of Pharmaceutical Sciences. All rights reserved.

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