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De B.,Regional Institute of Pharmaceutical Science and Technology | Adhikari I.,Regional Institute of Pharmaceutical Science and Technology | Nandy A.,University of Calcutta | Saha A.,University of Calcutta | Goswami B.B.,Regional Institute of Pharmaceutical Science and Technology
Journal of Molecular Structure | Year: 2017

Design and development of antioxidant supplements constitute an essential aspect of research in order to derive molecules that would help to combat the free radical invasion to the human body and curb oxidative stress related diseases. The present work deals with the development of in silico models for a series of thiazolidine derivatives having antioxidant potential. The objective of the work is to obtain models that would help to design new thazolidine derivatives based on substituent modification and thereby predict their activity profile. The QSAR model thus developed helps in quantification of the extent of contribution of the various molecular fragments towards the activity of the molecules, while the 3D pharmacophore model provides a brief idea of the essential molecular features that help the molecules to interact with the neighbouring free radicals. Both the models have been extensively validated which ensures their predictive ability as well the potential to search molecular databases for selection of thiazolidine derivatives with potent antioxidant activity. The models can thus be utilised effectively for database searching with the aim to isolate active antioxidants belonging to the thiazolidine group. © 2017 Elsevier B.V.

De B.,Regional Institute of Pharmaceutical Science and Technology
Journal of Herbal Medicine | Year: 2011

In the last few decades eco-friendly, bio-friendly, cost-effective and relatively safe herbal medicines have moved from the fringe to the mainstream with increased research in the field of traditional medicine. Medicinal plants are an integral component of alternative medical care. For millennia, Indian people traditionally played an important role in the management of biological resources and were custodians of related knowledge that they acquired through trial and error over centuries. India has a rich wealth of medicinal plants and the potential to accept the challenge to meet the global demand for them. Ayurveda, Naturopathy, Unani, Siddha and folk medicine are the major healthcare systems in Indian society, which fully depend upon natural resources. The market for herbal drugs has grown at an impressive rate due to a global resurgence in traditional and alternative healthcare systems, and therefore medicinal plants have great economic importance. However loss of biodiversity, over-exploitation and unscientific use of medicinal plants, industrialization, biopiracy, together with lack of regulation and infrastructure are the major impediments to the growth of herbal medicine. Conservation, proper research based on traditional knowledge, quality control of herbal medicine and proper documentation are essential in the 21st century for the growth of herbal medicine usage. © 2011 Elsevier GmbH. All rights reserved.

De B.,Regional Institute of Pharmaceutical Science and Technology
Journal of Forestry Research | Year: 2011

An ethno-medicinal investigation was conducted to highlights the traditional knowledge of medicinal plants being used by the tribe in West and South district of Tripura. This paper provides information about the different uses of plants used in their primary health care system. Tripura is a small north-eastern state of India and also a part of both Himalayan and Indo-Burma biodiversity region. It is a goldmine of medicinal plants and use of different plants in tribal traditional heath care systems has long history. Nineteen different tribes in Tripura, depend on natural resources at a great extent. This paper documented 113 medicinal plant species from 56 families along with their botanical name, local name, family name, habit, medicinal parts used, and traditional usage of application. The dominant families are Euphorbiaceae (7 species), Apocynaceae (6 species), Fabaceae and Rubiaceae (5 species each), Caesalpiniaceae, Asteraceae, Liliaceae and Verbenaceae (4 species each), Combretaceae, Labiatae, Malvaceae, Rutaceae and Zingiberaceae (3 species each). Tribes of Tripura have rich traditional knowledge on plant based medicine. Different parts of the plants in crude form/plant extracts/ decoctions/infusion or pastes are employed in diverse veterinary and human diseases by the tribe's of Tripura in daily life. © 2011 Northeast Forestry University and Springer-Verlag Berlin Heidelberg.

Majumder T.,Bose Institute of India | De B.,Regional Institute of Pharmaceutical science and Technology | Goswami B.B.,Regional Institute of Pharmaceutical science and Technology | Kar S.,Seemanta Institute of Pharmaceutical science
Der Pharma Chemica | Year: 2011

Amination of 5-aminoarylamine-3-methyl-1-substituted pyrazole-4-carboxaldehydes with aromatic or aliphatic amines gives new 12 (13 - 24) compounds 5-aminoarylamine-3-methyl-1-substituted-4-(aryliminomethyl)-pyrazoles (13 - 24). All the newly synthesized products were characterized by the spectral studies. The Rf, pKa and Molar absorptivity studies were carried out for all the compounds. They were screened for antibacterial, analgesic and antiinflammatory studies. The pKa was correlated with the analgesic study and anti-inflammatory study and the plots were obtained.

Das N.,Regional Institute of Pharmaceutical Science and Technology | Bera T.,Jadavpur University | Mukherjee A.,University of Calcutta
International Journal of Pharma and Bio Sciences | Year: 2012

Biomaterials are biologically compatible materials or formations that can be used to treat, augment or replace tissues in physiological environment. Biomaterials are hybrid structures or may be derived exclusively from synthetic and natural materials. Hydrogels on the other hand are three dimensional crosslinked polymeric networks and can imbibe large amount of water or biological fluids. Hydrogels are extensively used in biomedical areas for a range of unique properties like environment responsiveness, bioadhesive properties, biocompatibility and biodegradability. Biocompatable hydrogels are particularly advantageous in a number of areas like drug delivery, wound management, tissue engineering and organ transplant. This review make an attempt to present a systematic understanding on diverge chemistry and applications of biomaterial hydrogels as applied in pharmaceutical and biomedical arena.

Paul S.B.,Assam University | Choudhury S.N.,ICFAI University, Tripura | De B.,Regional Institute of Pharmaceutical Science and Technology
Asian Journal of Chemistry | Year: 2012

The analgesic activity of the methanolic extract of leaves of Neptunia prostrate and its separated fractions were studied in acetic acid induced model. The in vivo antiinflammatory was also studied using Carageenan induced rat paw edema. The result of both the studies indicated that the extract and its components possessed significant analgesic activity as well as antiinflammatory activity at the dose 100 mg/Kg. Both the activities were compared with standard drug aspirin for analgesic and diclofenance sodium for antiinflammatory. The structure of the bioactive compound has been characterized on the basis of spectral data such as IR, 1H NMR, 13C NMR and mass spectral studies.

Choudhury S.N.,ICFAI University, Tripura | De B.,Regional Institute of Pharmaceutical Science and Technology | Paul S.B.,Assam University
Oriental Journal of Chemistry | Year: 2016

Basella rubra is a medicinal plant species found in India and other parts of Asia and tropical Africa. It improves the appetite, useful in biliousness, leprosy, dysentery, ulcers and it has antiviral and antipyretic activity. The red pigment from the fruit has good colouring ability. It is bright purple at pH 3-7. It is a good additive and a safe, non-poisonous colorant. At present, the dyestuff industry has grown rapidly because of the vital role played by small - scale sector, which is responsible for the production of azo, acids, basics and direct dyes. But such synthetic dyes have toxic effect and hence may not be useful in edible substances. Therefore keeping this in mind the structure of two separated compounds from the fruit pigment of medicinally important plant Besella rubra were elucidated. The structures of the compounds have been characterized on the basis of spectral data such as IR, 1H NMR,13C NMR and Mass spectral studies.

Dolui A.K.,Dibrugarh University | Debnath M.,Dibrugarh University | De B.,Regional Institute of Pharmaceutical Science and Technology
Asian Journal of Chemistry | Year: 2011

Earlier we reported the screening results of antifeedant activities of six fractions of methanolic extract of leaves of Heliotropium indicum. The fraction E showed highest antifeedant activity. In the present study a new compound E (2-ethyl-l,2,3,4-tetrahydro-6-hydroxymethylisoquinoline) has been isolated from fraction E. The characterization and structure elucidation of the compound E was carried out by determination of melting point, solubility, UV, HPLC, IR, NMR ( 1H NMR and 13C NMR) and LC-MS data. The compound E showed antifeedant activity comparable with those of standard insecticides viz., neemazal and endosulfan. The LC 50 value of the compound E was found to be 2.18 %.

Dolui A.K.,Dibrugarh University | Debnath M.,Dibrugarh University | De B.,Regional Institute of Pharmaceutical Science and Technology | Kumar A.,Dibrugarh University
Journal of Environmental Biology | Year: 2012

A new compound E was isolated from the methanolic extract of the leaves of Heliotropium indicum by chromatographic fractionation. In the present study, the effect of the compound E on reproduction of Helopeltis theivora has been evaluated. The acute toxicity study (LD50) and sub-acute toxicity studies (haematological, biochemical and histopathological parameters) in albino Swiss mice were carried out to evaluate the safety aspect of the compound E. The compound showed significant inhibitory effect on the reproductive life of H. theivora. The oviposition period, fecundity and hatching percentage of H. theivora were found to be 15.67days, 39.33 and 28.00 % respectively after treatment with 2% compound E, whereas the control value were found to be 20.33 days, 77.67 and 77.33% respectively. The LD50 of the compound was found to be 780 mg kg-1 in Swiss albino female mice. The compound did not show any toxicity in mice at sub-lethal dose treatment (78 mg kg -1 b. wt., once daily) for 21 days as evident from different haematological, biochemical and histopathological parameters in compound E treated group when compared with control. © 2012 Triveni Enterprises.

PubMed | Regional Institute of Pharmaceutical Science and Technology
Type: Journal Article | Journal: Current computer-aided drug design | Year: 2016

The endogeneous antioxidant mechanism often fails to combat the huge free radical overload necessitating external antioxidant supplementation. Thus identification and definite structural manipulation of the naturally available antioxidant derivatives using in silico methodology help to design new moieties with improved therapeutic potential.The present work has been performed with the aim to identify the essential molecular fragments that contribute to the antioxidant property of the coumarin derivatives.In this work three separate chemometric methods were utilised to highlight the structural requisites of the coumarin derivatives.The QSAR model thus developed helps to highlight the prime molecular fragments, while the 3D pharmacophore model denotes the features constituting the biological pharmacophore for the coumarin derivatives. Again, the HQSAR contour signifies the relative contribution of the different molecular fragments.In silico techniques thus adapted in the present work highlight a significant paradigm in the process of screening and designing therapeutically active antioxidant moieties.

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