Regional Institute of Paramedical and Nursing science RIPANS

Aizawl, India

Regional Institute of Paramedical and Nursing science RIPANS

Aizawl, India
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Pachuau L.,Regional Institute of Paramedical and Nursing science RIPANS | Mazumder B.,Dibrugarh University
Carbohydrate Polymers | Year: 2012

The purpose of this research was to develop and evaluate controlled release matrix tablets of paracetamol based on natural gum exudates of Albizia procera. Procera gum was characterized of its properties like compressibility index, angle of repose, viscosity and moisture content. The interaction between the gum and paracetamol was also studied through differential scanning calorimetry (DSC) and FTIR spectroscopy. Matrix tablets were then prepared by wet granulation method with different concentrations of procera gum and hydroxypropyl methylcellulose (HPMC) and evaluated for their physical properties like weight variation, hardness, friability and content uniformity. Dissolution study was conducted to characterize release mechanism from the matrix system and data were fitted to various kinetic models. The mechanism of drug release from both types of matrix tablets was found to be anomalous type. Results from various evaluations suggested that A. procera gum could be used as drug release retardant in controlled release matrix systems. © 2012 Elsevier Ltd.


Pachuau L.,Regional Institute of Paramedical and Nursing science RIPANS | Lalhlenmawia H.,Regional Institute of Paramedical and Nursing science RIPANS | Mazumder B.,Dibrugarh University
Industrial Crops and Products | Year: 2012

The monosaccharide composition and physicochemical properties of Albizia procera gum was investigated. The crude exudate gum was reddish brown in color yielding a clear solution in water. The flow property of powdered and dried gum was established through Carr's index and angle of repose. It was observed that the gum possesses a fairly good flow property. Total carbohydrates, ash, protein and moisture contents were determined to show its purity. Rheology of 5% solution of the gum was studied in Brookfield viscometer. FTIR spectrum was recorded and DSC analysis was also performed. Scanning electron microscopy was performed to study the morphology of the gum. Monosaccharide constituents were separated and analyzed by High performance anion exchange chromatography-PAD system with gold electrodes after acid hydrolysis. It was found that arabinose and galactose were the main monosaccharides present in the exudate gum. © 2012 Elsevier B.V.


T. V.S.,Anna University | Henry L.J.K.,Anna University | Narra K.,Anna University | Lalduhsanga P.,Regional Institute of Paramedical and Nursing science RIPANS | And 2 more authors.
International Journal of Biological Macromolecules | Year: 2016

The present study deals with the development of natural macromolecule gum Albizia stipulata (AS) based novel pharmaceutical excipient for the controlled-release of paracetamol (PC). Central composite design (CCD) two-factor, five-level was used for the optimization of independent variables AS gum and compression force (CF) based on desired response variable drug release (DR) of paracetamol matrix tablets (PCMT). The optimized PCMT was prepared by wet granulation method and screened for pre- and post- compression parameters, and were characterized. The optimized PCMT (F14) formulation showed favorable in vitro release of PC (65%) in 12 h, and the release kinetics followed zero order anomalous diffusion mechanism. AS gum exerted significant (p < 0.001) anticancer activity with 98.25% inhibition at 2000 μg/mL (IC50 = 179.12 μg/mL) against A549 cell line. PC and PCMT showed 78.56% inhibition (IC50 value = 856.58 μg/mL) and 93.68% inhibition (IC50 value = 396.35 μg/mL) respectively, symbolizing that the gum remarkably potentiated the anticancer effect of PC in formulation after 24 h treatment by inducing apoptosis. This is the first report on A. stipulata gum as a promising biopolymer for drug delivery application in cancer therapeutics. © 2016 Elsevier B.V.


Seelan T.V.,Anna University | Kumari H.L.J.,Anna University | Kishore N.,Anna University | Selvamani P.,Anna University | And 5 more authors.
International Journal of Biological Macromolecules | Year: 2016

The present study deals with the formulation of pH-sensitive mucoadhesive beads using natural gum isolated from Prunus cerasoides (PC) in combination with sodium alginate (SA) for the controlled release of diclofenac sodium (DS). PC and SA composite (PC-SA), DS loaded SA (DS-SA) and DS loaded PC-SA (DS-PC-SA) beads were prepared by ionotropic gelation method. The absence of interaction between DS and PC-SA was shown by FTIR, DSC and TGA analyses. The optimized DS-PC-SA formulation exhibited mucoadhesive property and the controlled release of DS was achieved 68% in 12. h. The in vitro release kinetics follows zero order with anomalous diffusion mechanism. Therefore, the formulated mucoadhesive beads with the novel gum are preferable for the controlled release of DS by prolonging the residence time of the drug in the gastrointestinal tract, overcoming the problems associated with the immediate release dosage forms of DS. © 2016 Elsevier B.V.


PubMed | Regional Institute of Paramedical and Nursing science RIPANS, Anna University and Assam University
Type: | Journal: International journal of biological macromolecules | Year: 2016

The present study deals with the formulation of pH-sensitive mucoadhesive beads using natural gum isolated from Prunus cerasoides (PC) in combination with sodium alginate (SA) for the controlled release of diclofenac sodium (DS). PC and SA composite (PC-SA), DS loaded SA (DS-SA) and DS loaded PC-SA (DS-PC-SA) beads were prepared by ionotropic gelation method. The absence of interaction between DS and PC-SA was shown by FTIR, DSC and TGA analyses. The optimized DS-PC-SA formulation exhibited mucoadhesive property and the controlled release of DS was achieved 68% in 12h. The in vitro release kinetics follows zero order with anomalous diffusion mechanism. Therefore, the formulated mucoadhesive beads with the novel gum are preferable for the controlled release of DS by prolonging the residence time of the drug in the gastrointestinal tract, overcoming the problems associated with the immediate release dosage forms of DS.


PubMed | Regional Institute of Paramedical and Nursing science RIPANS and Anna University
Type: | Journal: International journal of biological macromolecules | Year: 2016

The present study deals with the development of natural macromolecule gum Albizia stipulata (AS) based novel pharmaceutical excipient for the controlled-release of paracetamol (PC). Central composite design (CCD) two-factor, five-level was used for the optimization of independent variables AS gum and compression force (CF) based on desired response variable drug release (DR) of paracetamol matrix tablets (PCMT). The optimized PCMT was prepared by wet granulation method and screened for pre- and post- compression parameters, and were characterized. The optimized PCMT (F

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