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Holstebro, Denmark

Nielsen S.Y.,Regional Hospital West Jutland
Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin | Year: 2013

Q fever is a zoonotic infection which can pose a danger to pregnant women. To our knowledge, Denmark has never experienced a clinically verified Q fever outbreak. We aimed to quantify risk of infection in pregnant women occupationally and environmentally exposed to Coxiella burnetii. The Danish National Birth Cohort collected blood samples from 100,418 pregnant women in the period 1996 to 2002. We sampled 195 women with occupational exposure to livestock (veterinarians and female farmers), 202 women with domestic exposure (dairy cattle and/or sheep) and a random sample of 459 unexposed women. Samples were screened for antibodies against C. burnetii by commercial enzyme-linked immunosorbent assay. Positive samples were confirmed by immunofluorescence (cut-off titre ≥1:128). The proportion of seropositive women was higher in the occupationally exposed (47.2% seropositive; relative risk (RR): 9.8; 95% confidence interval (CI): 6.4-15.2) and the domestically exposed population (32.2% seropositive; RR: 6.7; 95% CI: 4.3-10.6) than in unexposed women (4.8% seropositive). We found a high prevalence of antibodies to C. burnetii among pregnant women with occupational or domestic exposure to cattle and/or sheep compared with unexposed pregnant women. Our findings suggest that contact to livestock is a risk factor for C. burnetii infection in Denmark. Source

Biering K.,Regional Hospital West Jutland | Biering K.,Danish Ramazzini Center | Frydenberg M.,University of Aarhus | Hjollund N.H.,WestChronic | Hjollund N.H.,Aarhus University Hospital
Clinical Epidemiology | Year: 2014

Objective: Improvements in the treatment of coronary heart disease have increased the number of patients living with a chronic heart disease. Patient-reported outcomes are required to adequately describe prognosis. We report self-rated health in a population-based cohort of patients with coronary heart disease treated with percutaneous coronary intervention (PCI). Methods: Over 3 years, we followed 1,726 patients under 65 years treated with PCI with eight repetitive questionnaires. With the use of multiple imputation, we described the course of self-rated health using the short form 12-item survey’s mental component summary (MCS) and physical component summary (PCS) and analyzed adjusted differences by sex, age, educational level, indication for PCI, and left ventricular ejection fraction along with an analysis of decrease in health status. Results: MCS scores increased during follow-up, while PCS scores were stable over time. Men rated higher in MCS and PCS than women, and older patients rated higher in MCS than younger. Other differences were negligible. Younger age was identifed as a risk factor for marked decrease in mental health over time. Conclusion: In a complete population-based cohort of PCI patients with multiple measurements, we found improvements in mental, but not physical health over time. Demographic differences in health were larger than disease-related differences. © 2014 Biering et al. Source

Biering K.,Regional Hospital West Jutland | Biering K.,Danish Ramazzini Center | Hjollund N.H.,Regional Hospital West Jutland | Hjollund N.H.,Aarhus University Hospital | And 3 more authors.
Journal of Occupational Rehabilitation | Year: 2013

Purpose Methods of measuring return to work (RTW) following temporary disability are diverse. The purpose of this study was to compare different measures of RTW within a 12-month period using a well-defined population of patients treated with Percutaneous Coronary Intervention (PCI) and weekly administrative data on transfer payments. Methods Different RTW measures were defined based on weekly data from 12 months follow-up after PCI and agreement between definitions was expressed as Cohen's kappa. Prognostic factors for RTW were compared using logistic regression. Results Among those working before the PCI, 70 % were back to work at 6 months after the PCI and 76 % 1 year after when using cross-sectional measures and excluding those who left the workforce permanently during follow up. When using a time to event measure, 77 % experienced RTW during follow up, while only 60 % experienced RTW without recurrent sick-leave events during the following year. We found moderate to near perfect agreement when comparing the measures, with lowest agreement between the time-to-event measure without relapses compared to the other measures. When comparing prognostic factors for the different RTW outcomes, we found most associations similar in size, except from the clinical measure left ventricular ejection fraction, possibly related to recurrent sick leave. Conclusions Different measures revealed some differences in proportions of RTW. However, high agreement between RTW-definitions was found. Choice of RTW-definitions should depend on study purpose; simple cross-sectional methods are sufficient in prediction of RTW and analysis of risk factors, while methods capturing relapses are recommended when sustainability, prognosis and vulnerability are in focus. © 2012 Springer Science+Business Media New York. Source

Glassou E.N.,Regional Hospital West Jutland | Glassou E.N.,Aarhus University Hospital | Pedersen A.B.,Aarhus University Hospital | Hansen T.B.,Regional Hospital West Jutland | Hansen T.B.,University of Aarhus
Acta Orthopaedica | Year: 2014

Purpose-To compare the risks of re-admission, reoperation, and mortality within 90 days of surgery in orthopedic departments with well-documented fast-track arthroplasty programs with those in all other orthopedic departments in Denmark from 2005 to 2011. Methods-We used the Danish hip and knee arthroplasty registers to identify patients with primary total hip arthroplasty or total knee arthroplasty. Information about re-admission, reoperation, and mortality within 90 days of surgery was obtained from administrative databases. The fast-track cohort consisted of 6 departments. The national comparison cohort consisted of all other orthopedic departments. Regression methods were used to calculate relative risk (RR) of adverse events, adjusting for age, sex, type of fixation, and comorbidity. Cohorts were divided into 3 time periods: 2005-2007, 2008-2009, and 2010-2011. Results-79,098 arthroplasties were included: 17,284 in the fast-track cohort and 61,814 in the national cohort. Median length of stay (LOS) was less for the fast-track cohort in all 3 time periods (4, 3, and 3 days as opposed to 6, 4, and 3 days). RR of re-admission due to infection was higher in the fast-track cohort in 2005-2007 (1.3, 95% CI: 1.1-1.6) than in the national cohort in the same time period. This was mainly due to urinary tract infections. RR of re-admission due to a thromboembolic event was lower in the fast-track cohort in 2010-2011 (0.7, CI: 0.6-0.9) than in the national cohort in the same time period. No differences were seen in the risk of reoperation and mortality between the 2 cohorts during any time period. Interpretation-The general reduction in LOS indicates that fast-track arthroplasty programs have been widely implemented in Denmark. At the same time, it appears that dedicated fasttrack departments have been able to optimize the fast-track program further without any rise in re-admission, reoperation, and mortality rates. Source

Jeune B.,University of Southern Denmark | Eriksen M.L.,Regional Hospital West Jutland | Andersen-Ranberg K.,Institute of Public Health | Bronnum-Hansen H.,Copenhagen University
Scandinavian Journal of Public Health | Year: 2015

Aims: In Denmark life expectancy (LE) has increased since 1995 after a long period of stagnation. Healthy life expectancy (HLE) at age 65 increased more than LE during the period 1987-2005. The aim of the study was to determine the trend in HLE in Denmark at ages 50 and 65 during the period 2004-2011. Methods: The study was based on nationwide register data on mortality and data on health status from the SHARE surveys carried out in 2004/2005, 2006/2007 and 2010/2011. Expected lifetime in various health states was estimated by Sullivan's method. Changes from 2004 to 2011 were decomposed into contributions from changes in mortality and prevalence of activity limitations. Results: During the period 2004-2011 LE increased by about 1 year at both age 50 and age 65. However, the increase in expected lifetime in self-rated good health, without long-term health problems and without activity limitations was even longer in both genders and it increased by 1.5-4.0 years depending on age, gender and health indicator. Consequently, expected lifetime in an unhealthy state decreased and the proportions of lifetime in a healthy state increased. The disability effect of the health gain was stronger than the mortality effect. Conclusions:In Denmark HLE increased substantially more than LE during the period 2004-2011 for all three health indicators at both age 50 and age 65, and for both genders. Thus, the improvement in health expectancy continued in Denmark in recent years. © 2015 the Nordic Societies of Public Health. Source

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