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Liège, Belgium

Pierard-Franchimont C.,University of Liege | Lesuisse M.,Regional Hospital Citadelle | Humbert P.,University of Franche Comte | Humbert P.,University Hospital Saint Jacques | And 4 more authors.
Current Drug Safety | Year: 2012

Folates are one-carbon donors essential for synthesizing purines, pyrimidines, serine, and methionine. They correspond to anionic hydrophilic molecules essential for DNA synthesis in mammalian cells. The latter cells lack the capacity to synthesize folates. In some patients, high dosages of antifolate drugs (eg: methotrexate, pemetrexed) used in cancer chemotherapy alter the keratinocytes, endothelial cells and Factor XIIIa+ dermal dendrocytes in a range of various severities. Such conditions clinically designed under the heading antifolate cytotoxic skin reaction (ACSR) occasionally resemble the toxic epidermal necrolysis (TEN)/Stevens-Johnson syndrome (SJS) spectrum. Whether or not the TEN/SJS presentation of ACSR is a regular condition similar to that induced by other drugs or a variant condition supported by a unique pathomechanism is unsettled. © 2012 Bentham Science Publishers.


Hermanns-Le T.,University of Liege | Berardesca E.,San Gallicano Dermatological Institute | Pierard G.E.,University of Liege | Lesuisse M.,Regional Hospital Citadelle | Pierard-Franchimont C.,University of Liege
Journal of Biomedicine and Biotechnology | Year: 2012

In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations. © 2012 Trinh Hermanns-Lê et al.


Hermanns-Le T.,University of Liege | Hermanns-Le T.,Diagnostic Center | Hermanns J.-F.,University of Liege | Hermanns J.-F.,Diagnostic Center | And 2 more authors.
BioMed Research International | Year: 2013

Circulating sex hormones follow major fluctuations during the ovarian cycle. The so-called premenstrual syndrome represents a global condition grouping the diversity of catamenial disorders. At the skin level, the sebaceous gland activity is obviously modulated by these endocrine fluctuations. In addition, a series of pathological manifestations take place simultaneously in some women. Among them, the most frequent skin condition is represented by catamenial acne. Concurrently, the autoimmune progesterone dermatitis refers to a diversity of skin alterations resulting from an immune reaction to progesterone. It is present under variable clinical aspects. A series of other recurrent skin conditions are not specifically induced but are merely exacerbated at the end of the ovarian cycle. © 2013 Trinh Hermanns-Lê et al.


Szepetiuk G.,Regional Hospital Citadelle | Lesuisse M.,Regional Hospital Citadelle | Pierard G.E.,University of Liege | Quatresooz P.,University of Liege | Pierard-Franchimont C.,University of Liege
Case Reports in Dermatology | Year: 2012

Aim: Both interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic granulomatous dermatitis (PNGD) are rare disorders typically associated with systemic autoimmune conditions. They probably represent different aspects of a disease spectrum encompassing the concept of autoimmunity-related granulomatous dermatitis (ARGD). Case Report: A 61-year-old woman presented with ARGD and autoimmune hepatitis. The clinical presentation suggested PNGD, while histopathology was consistent with IGD. Discussion: The association of ARGD with autoimmune hepatitis is apparently a rare event. The present case shows that the clinicopathological correlation in ARGD does not always clearly fit with the classical presentations of IGD or PNGD. Copyright © 2012 S. Karger AG, Basel.


Doyen J.,Regional Hospital Citadelle | Demoulin S.,University of Liege | Delbecque K.,University of Liege | Goffin F.,Regional Hospital Citadelle | And 2 more authors.
BioMed Research International | Year: 2014

The objective of this paper is to present general considerations which should be kept in mind by clinicians in charge of women with vulvar diseases. Four representative vulvar dermatoses are described. Lichen simplex chronicus is a pathological condition related to chemical and mechanical irritant agents. Detrimental effects of these irritants, in the presence of other dermatoses, have to be considered when therapeutic responses are unsatisfactory. Lichen sclerosus is the most common vulvar dermatosis in elderly. However, it should be kept in mind that it may be diagnosed at any age. Lichen planus, in spite of sharing a similar range of etiological factors with lichen sclerosus, is a very distinct entity. Finally, Paget's disease, although rare, is also described especially because of the challenge it represents both clinically and therapeutically. © 2014 Jean Doyen et al.

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