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Dundalk, Ireland

To combat social and economic inequity in rural Australia, governments, communities, and policy makers are seeking ways to empower local residents to find local solutions to local problems. Through an exploratory review of the literature and semi-structured interviews conducted in the Mid West of Western Australia, this research examined the role of the arts as a vehicle for increased social and civic participation to build resilience to inequity. For those interviewed, the arts were observed to strengthen sense of place and community identity. The arts were utilised as a means for encouraging and enabling civic participation, as well as providing opportunities for social interaction and networking, which are essential for the health and wellbeing of rural and remote residents. While providing a context for civic and social participation, the arts were viewed by several of those interviewed as a means for facilitating understanding between divisive and disparate groups. Yet, it was noted that the execution and drive for arts activities and events was dependent on the availability of human capital, but also on support from governance and funding authorities to build capacity to sustain these activities. If, as suggested by this exploratory review, the arts are a vehicle for building resilience in rural Australia, then further research is needed to support these claims to enable continued and future support for not just the arts, but the capacity of communities to engage in the arts. © 2011 Elsevier Ltd. Source

Wetzstein S.,Regional Development Centre
Geography Compass | Year: 2013

This article explores the nexus between urban economic governance, business and globalisation in light of new empirical research about the emergence of 'Committee-for-[City]' entities in Australasia. It critically reviews key claims of the international literature on business-mediated urban economic governance from both structural and post-structural urban political economy, business mobilisation and globalisation perspectives in order to test these largely northern hemisphere-centric theories against new research findings on business as emergent political and policy actor in Perth, Melbourne, Sydney and Auckland. On the basis of a conceptualisation that contemporary 'at-a-distance' urban economic interventions are essentially discursive public-private partnerships, the paper highlights the important role of business interests in the context of a co-opting and partnering state. Although it is found that established notions such as 'urban growth machines' and 'entrepreneurial governance' are (still) relevant to explain the nature and work of these new business governance actors in Australasia, the influence of globalising processes and the constitutive nature of the institutional and socio-economic context must be more thoroughly acknowledged. The hybrid nature of the governing objectives pursued and the multiplicity of political projects at work mean that governance and investment outcomes resulting from business-mediated urban economic interventions cannot be assumed but must be traced and evaluated in careful empirical investigations. © 2013 The Author(s) Geography Compass © 2013 John Wiley & Sons Ltd. Source

Ciocca D.R.,CONICET | Arrigo A.P.,Regional Development Centre | Calderwood S.K.,Beth Israel Deaconess Medical Center
Archives of Toxicology | Year: 2013

Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their rapid and abundant induction by stress. HSP genes are activated at the transcriptional level by heat shock transcription factor 1 (HSF1). During the progression ofmany types of cancer, this heat shock transcriptional regulon becomes co-opted by mechanisms that are currently unclear, although evidently triggered in the emerging tumor cell. Concerted activation of HSF1 and the accumulation of HSPs then participate in many of the traits that permit the malignant phenotype. Thus, cancers of many histologies exhibit activated HSF1 and increased HSP levels that may help to deter tumor suppression and evade therapy in the clinic. We review here the extensive work that has been carried out and is still in progress aimed at (1) understanding the oncogenic mechanisms by which HSP genes are switched on, (2) determining the roles of HSF1/HSP in malignant transformation and (3) discovering approaches to therapy based on disrupting the influence of the HSF1-controlled transcriptome in cancer. © The Author(s) 2012. Source

Wetzstein S.,Regional Development Centre
Geographical Research | Year: 2013

This paper explores how territorial economic governance is discursively constituted in a globalising and neoliberalising world. It acknowledges both the increasingly recognised formative role of spatial imaginaries in economic interventions and the workings of co-constitutive political projects that link particular imaginaries with political ambitions and policy strategies. Embracing recent calls for comparative ethnographic urban research at the local-global interface, it explores currently dominant spatial imaginaries across the four Australasian cities of Auckland, Sydney, Melbourne, and Perth. Based on multiple qualitative methods, this study claims that a considerable number of actor's spatial associations and reference points can be related to particular city-specific governmental projects; Auckland's Super-City, Sydney's Global and Green City, Melbourne's Liveable City, and Perth's Vibrant City. It is demonstrated how discursive governance techniques such as 'story-telling', benchmarking, and policy transfer have been pivotal in the activation, circulation, and performance of those spatial imaginaries and their transformation into temporarily dominant visions for strategic urban interventions aimed at repositioning urban actors, spaces, and activities. While spatial imaginaries can be related to differently framed global aspirations, the effects of spatial political projects on urban governance and investment trajectories differ significantly across space. Theoretically, the paper stresses the importance of particular conceptions of territorial relations and time- and place-specific institutional mediation in shaping context-dependent discursive material governance alignments. © 2012 Institute of Australian Geographers. Source

Shen J.,Regional Development Centre
Habitat International | Year: 2014

The integration of cross-border regions involves at least three dimensions, i.e., economic integration, institutional integration and social integration. The relationship and the gaps among these processes of integration need detailed studies in the context of increasing number of cross-border regions. The empirical focus of this paper is the cross-boundary integration of Hong Kong and Shenzhen, two major cities that have played a pivotal role in China's urbanization, development and internationalization over the last three decades. It is revealed that economic integration prevails in the Hong Kong-Shenzhen integrated region. Economic integration has necessitated the institutional integration which in turn attempts to facilitate economic integration. But both economic and institutional integration cannot change the pace of social integration. Social integration lags significantly behind economic and institutional integration. Brunet-Jailly's main hypothesis of the theory of borderland studies is only partially valid in Hong Kong-Shenzhen region. The paper concludes that Hong Kong-Shenzhen has not yet become a twin city.© 2013 Elsevier Ltd. Source

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