Magnitogorsk, Russia
Magnitogorsk, Russia

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Ott P.A.,Regional Clinical Oncology Center | Privalov A.V.,Regional Clinical Oncology Center | Vazhenin A.V.,Regional Clinical Oncology Center | Nadvikova E.A.,Regional Clinical Oncology Center | And 3 more authors.
Voprosy Onkologii | Year: 2013

Nowadays the most popular and justified, from oncological positions, method of treatment for soft tissue sarcomas is a combined approach with the use of conservative surgery followed by postoperative radiation therapy. In this regard, intraoperative radiation therapy (IORT) in a single dose of 10-20 Gy is a method that optimizes the role of radiation therapy in treatment of this pathology allowing precise localization of radiation zone within the "tumor bed", thereby minimizing damage of normal tissues and critical organs. The aim of the study was to investigate the effect of IORT on the frequency and structure of post-operative complications. Testing group (n = 49) was compared to the group without IORT (n = 57) and group with only surgery (n = 171). According to the study it was not obtained statistically significant differences in the incidence of postoperative complications in the groups (p = 0,57), not marked influence on the structure of post-operative complications.

Gervas P.,Federal State Budgetary Scientific Institution | Ivanova A.,Federal State Budgetary Scientific Institution | Vasiliev N.,Federal State Budgetary Scientific Institution | Ananina O.,Federal State Budgetary Scientific Institution | And 10 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2015

Background: Incorporation of molecular analysis of the epidermal growth factor receptor (EGFR) gene into routine clinical practice has shown great promise to provide personalized therapy of the non-small cell lung cancer (NSCLC) in the developed world. However, the genetic testing of EGFR mutations has not yet become routine clinical practice in territories remote from the central regions of Russia. Therefore, we aimed to study the frequency of major types of activating mutations of the EGFR gene in NSCLC patients residing in West Siberia. Materials and Methods: We examined EGFR mutations in exons 19 and 21 in 147 NSCLC patients (excluding squamous cell lung carcinomas) by real time polymerase chain reaction. Results: EGFR mutations were detected in 28 of the 147 (19%) patients. There were 19 (13%) cases with mutations in exon 19 and 9 cases (6%) in exon 21. Mutations were more frequently observed in women (42%, p=0.000) than in men (1%). A significantly higher incidence of EGFR mutations was observed in bronchioloalveolar carcinomas (28%, p=0.019) and in adenocarcinomas (21%, p=0.024) than in large cell carcinomas, mixed adenocarcinomas, and NOS (4%). The EGFR mutation rate was much higher in never-smokers than in smokers: 38% vs. 3% (p=0.000). The frequency of EGFR mutations in the Kemerovo and Tomsk regions was 19%. Conclusions: The incorporation of molecular analysis of the EGFR gene into routine clinical practice will allow clinicians to provide personalised therapy, resulting in a significant increase in survival rates and improvement in life quality of advanced NSCLC patients.

Rodionov V.V.,Ulyanovsk State University | Panchenko S.V.,Regional Clinical Oncology Center | Idrisova S.R.,Regional Clinical Oncology Center | Kometova V.V.,Regional Clinical Oncology Center | Savinov Yu.G.,Ulyanovsk State University
Voprosy Onkologii | Year: 2015

It was retrospectively analyzed clinicopathological features of 529 breast cancer patients treated at the Ulyanovsk Oncology Center. Of 529 patients 235 (44,4%) had at least one positive axillary lymph node. Tumor size (p=0,0005), histological grade (p=0004), lymphovascular invasion (p<0.0001), HER2-status (p=0,014) and total score of malignancy (p<0,0001) were significant independent predictors for lymph nodes metastases. By univariate and multivariate regression analysis it was created the graphic variant of nomogram which could predict the risk of lymph nodes metastases in breast cancer patients. An area under ROC-curve in our nomogram reached 0,737 that demonstrated high prediction level of accuracy of the developed model. Thus new nomogram is a useful tool in planning axillary surgery in breast cancer patients.

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