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Ordodi V.,Victor Babes University of Medicine and Pharmacy Timisoara | Dumitrel G.-A.,Polytechnic University of Timisoara | Gruia A.,Regional Center for Transplant Immunology | Iacob M.,Polytechnic University of Timisoara | And 2 more authors.
Revista de Chimie | Year: 2010

The appearance of cytostatic-cytotoxic drugs in the environment constitutes a threat to ecosystems and human health. The pollution source with such chemicals is represented by waste water from the health institutions which treat patients with oncological diseases. The paper presents a fully automatic experimental installation of small dimensions to eliminate cytostatics from waste water. Testing the installation was done by assessing the performance of depuration of synthetic and real samples with cytotoxic effect-methotrexate. The functioning of the experimental micro-installation, by its original concept, favors unfolding reactions of interest (chemical and electrochemical oxidation) with a minimal consumption of power also providing a minimal duration of electrolysis process. Source

Botinestean C.,Sudan University of Science and Technology | Gruia A.T.,Regional Center for Transplant Immunology | Jianu I.,Sudan University of Science and Technology
Journal of Material Cycles and Waste Management | Year: 2014

The increase of waste quantities from tomato processing industry is an important ecological and also financial problem. Seeds are the major component of this waste and one valuable alternative of transforming them into raw materials is oil extraction. The isolated oil can be used for nutritive or industrial purposes. In this research, the influence of some extraction parameters (time, solvent and granularity of tomato milled seeds) on the fatty acid (FA) composition, water content and water reaction rate has been evaluated. The FA composition of tomato seed oil, determined by gas chromatography-mass spectrometry, has shown a high content of linoleic acid (20.8-39.9 mg/mL), followed by palmitic acid (6.3-19.3 mg/mL), oleic acid (2.5-14.2 mg/mL), linolenic acid (0.7-4.9 mg/mL), stearic acid (0.1-0.8 mg/mL), palmitoleic acid (0.03-0.5 mg/mL), arachidic acid (0.08-0.4 mg/mL), myristic acid (0.05-0.2 mg/mL) and margaric acid (0.02-0.11 mg/mL). The oil content of tomato seeds was registered in the range of 13.3-19.3 %. For evaluation of water content, a method using Karl Fischer titration (KFT) has been established. Comparing with the physical methods that do not distinguish the water content from volatile matter, KFT is an important technique, very accurate, that determines water content by a chemical reaction. © 2014 Springer Japan. Source

Boldeanu F.M.,Regional Center for Transplant Immunology | Boldeanu F.M.,Victor Babes University of Medicine and Pharmacy Timisoara | Gruia A.T.,Regional Center for Transplant Immunology | Ordodi V.L.,Victor Babes University of Medicine and Pharmacy Timisoara | And 3 more authors.
Revista Romana de Medicina de Laborator | Year: 2012

Most minimal residual disease-directed therapeutic interventions in current treatment protocols for acute lymphoblastic leukemia (ALL) are based on bone marrow and peripheral blood testing. In this study, we employed real-time quantitative polymerase chain reaction analysis (Real Time PCR) to examine minimal residual disease (MRD) in 28 patients (pts) with ALL, 36% receiving transplantation from related donors and 64% receiving trans- plantation from nonrelated donors. Determined MRD positivity ranged from positive below quantitative range (2 pts, 7.17%), between 0.01% and 0.1% (1 pts, 3.57%), and higher than 0.1% (6 pts., 21.42%). Eight patients were MRD negative and during observation the MRD became positive. Two patients determined to be MRD positive (0.0001%) in the early phase showed subsequent increase of MRD load, while another two, who were determined to be positive in the later phase did not. We had two patients with strong positive MRD in which during observation the MRD turned to negative due to clinical intervention. However, for 5 patients with high MRD load the induction of remission was not obtained. As a perspective, a well characterized and homogenous patient cohort should be enrolled in a clinical study to investigate the impact of post transplant MRD on the outcome. Source

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