Regenerative Medicine Research Center

Yantai, China

Regenerative Medicine Research Center

Yantai, China
SEARCH FILTERS
Time filter
Source Type

News Article | December 14, 2016
Site: techcrunch.com

Scientists at Sichuan Revotek and the Regenerative Medicine Research Center of West China Hospital at Sichuan University have successfully embedded 3D-printed blood vessels into simian test subjects. The vessels, which are made of stem cell-based organic material, were a major breakthrough in vascular regeneration. According to 3Ders the system uses “stem cell bioink, which was prepared from the autologous adipose mesenchymal stem cells (ADSCs) of the monkeys.” Essentially the material came from the monkeys themselves and were not subject to organ rejection. The process involves creating a 3D-printed scaffold of biological material that grafts to natural blood vessels and are virtually indistinguishable from the monkey’s natural organs. This means that real, usable organs and be printed and implanted in a few hours with minimum invasiveness. “The tissues we implanted will have mingled with the original ones and grown into a regular vessel,” said researcher Kang Yujian. “This is unprecedented.” You can check out another fairly gory video here or watch a short animation below.


Wang X.-L.,Qingdao University | He S.,Maternal and Child Health Hospital | Zhai H.-L.,Regenerative Medicine Research Center
International Journal of Clinical and Experimental Medicine | Year: 2015

Objective: The influence of β2-microglobulin (β2-MG) on the prognosis of non-Hodgkin’s lymphoma (NHL) remains controversial. This study performed meta-analyses to evaluate the prognostic value of β2-MG on the overall survival (OS) of NHL. Methods: Through a search of relevant literature in PubMed, EMbase, Science Direct, OVID and Wanfang databases from 1980-2013, the hazard ratios (HRs) of OS between the normal β2-MG group and the increased β2-MG group were retrieved, and the results were combined using a fixed effect model and a random effect model. Subgroup analyses were performed based on univariate and multivariate analysis results, and sensitivity analyses were performed to estimate the changes of the combined HRs. In addition, funnel plots and fail-safe numbers were used to estimate publication bias. Results: A total of 17 qualified publications were included, with a cumulative total of 2,479 cases. The result of heterogeneity examination showed that there was heterogeneity among all studies (P < 0.001, I2 = 87%). In the random effect model, the combined HR was 2.71 (95% confidence interval [CI]: 1.91-3.85). The result of the total effect examination was statistically significant (Z = 5.59, P < 0.001). Conclusion: The increased β2-MG level was an independent risk factor for the prognosis of NHL. © 2015, Int J Clin Exp Med. All rights reserved.


PubMed | Yantai University, Regenerative Medicine Research Center and Maternal and Child Health Hospital Jiangshan 324100
Type: Journal Article | Journal: International journal of clinical and experimental medicine | Year: 2015

The influence of 2-microglobulin (2-MG) on the prognosis of non-Hodgkins lymphoma (NHL) remains controversial. This study performed meta-analyses to evaluate the prognostic value of 2-MG on the overall survival (OS) of NHL.Through a search of relevant literature in PubMed, EMbase, Science Direct, OVID and Wanfang databases from 1980-2013, the hazard ratios (HRs) of OS between the normal 2-MG group and the increased 2-MG group were retrieved, and the results were combined using a fixed effect model and a random effect model. Subgroup analyses were performed based on univariate and multivariate analysis results, and sensitivity analyses were performed to estimate the changes of the combined HRs. In addition, funnel plots and fail-safe numbers were used to estimate publication bias.A total of 17 qualified publications were included, with a cumulative total of 2,479 cases. The result of heterogeneity examination showed that there was heterogeneity among all studies (P < 0.001, I(2) = 87%). In the random effect model, the combined HR was 2.71 (95% confidence interval [CI]: 1.91-3.85). The result of the total effect examination was statistically significant (Z = 5.59, P < 0.001).The increased 2-MG level was an independent risk factor for the prognosis of NHL.


Li X.,Regenerative Medicine Research Center | Chen Y.,Regenerative Medicine Research Center | Liu J.,Regenerative Medicine Research Center | Yang G.,University of Sichuan | And 7 more authors.
Experimental Biology and Medicine | Year: 2012

Dyslipidemia caused by 'Western-diet pattern' is a strong risk factor for the onset of diabetes. This study aimed to disclose the relationship between the serum metabolite changes induced by habitual intake of high-fat and high-cholesterol (HFHC) diet and the development of impaired glucose tolerance (IGT) and insulin resistance through animal models of Macaca mulatta. Sixteen M. mulatta (six months old) were fed a control diet or a HFHC diet for 18 months. The diet effect on serum metabolic profiles was investigated by longitudinal research. Islet function was assessed by intravenous glucose tolerance and hyperinsulinemic - euglycemic clamp test. Metabonomics were determined by 1H proton nuclear magnetic resonance spectroscopy. Prolonged diet-dependent hyperlipidemia facilitated visceral fat accumulation in liver and skeletal muscle and disorder of glucose homeostasis in juvenile monkeys. Glucose disappearance rate (KGlu) and insulin response to the glucose challenge effects in HFHC monkeys were significantly lower than in control monkeys. Otherwise, serum trimethylamine-N-oxide (TMAO), lactate and leucine/isoleucine were significantly higher in HFHC monkeys. Sphingomyelin and choline were the most positively correlated with KGlu (R2 = 0.778), as well as negative correlation (R2 = 0.64) with total cholesterol. The HFHC diet induced visceral fat, abnormal lipid metabolism and IGT prior to weight gain and body fat content increase in juvenile monkeys. We suggest that increased serum metabolites, such as TMAO, lactate, branched-chain amino acids and decreased sphingomyelin and choline, may serve as possible predictors for the evaluation of IGT and insulin resistance risks in the prediabetic state. © 2008 Society for Experimental Biology and Medicine.


Liu J.,Regenerative Medicine Research Center | Liu S.,Regenerative Medicine Research Center | Chen Y.,Regenerative Medicine Research Center | Zhao X.,University of Sichuan | And 2 more authors.
International Journal of Nanomedicine | Year: 2015

Islet transplantation is considered to be a curative treatment for type 1 diabetes mellitus. However, disruption of the extracellular matrix (ECM) leads to β-cell destruction and graft dysfunction. In this study, we developed a functionalized self-assembling peptide, KLD-F, with ECM mimic motifs derived from fibronectin and collagen IV, and evaluated its effect on β-cell function and proliferation. Atomic force microscopy and rheological results showed that KLD-F could self-assemble into a nanofibrous scaffold and change into a hydrogel in physiological saline condition. In a three-dimensional cell culture model, KLD-F improved ECM remodeling and cell-cell adhesion of INS-1 β-cells by upregulation of E-cadherin, fibronectin, and collagen IV. KLD-F also enhanced glucose-stimulated insulin secretion and expression of β-cell function genes, including Glut2, Ins1, MafA, and Pdx-1 in INS-1 cells. Moreover, KLD-F promoted proliferation of INS-1 β-cells and upregulated Ki67 expression by mediating cell cycle progression. In addition, KLD-F improved β-cell function and proliferation via an integrin/focal adhesion kinase/extracellular signal-regulated kinase/cyclin D pathway. This study highlights the fact that the β-cell-ECM interaction reestablished with this functionalized self-assembling peptide is a promising method to improve the therapeutic efficacy of islet transplantation. © 2015 Liu et al.


PubMed | Regenerative Medicine Research Center
Type: Journal Article | Journal: Experimental biology and medicine (Maywood, N.J.) | Year: 2012

Dyslipidemia caused by Western-diet pattern is a strong risk factor for the onset of diabetes. This study aimed to disclose the relationship between the serum metabolite changes induced by habitual intake of high-fat and high-cholesterol (HFHC) diet and the development of impaired glucose tolerance (IGT) and insulin resistance through animal models of Macaca mulatta. Sixteen M. mulatta (six months old) were fed a control diet or a HFHC diet for 18 months. The diet effect on serum metabolic profiles was investigated by longitudinal research. Islet function was assessed by intravenous glucose tolerance and hyperinsulinemic-euglycemic clamp test. Metabonomics were determined by (1)H proton nuclear magnetic resonance spectroscopy. Prolonged diet-dependent hyperlipidemia facilitated visceral fat accumulation in liver and skeletal muscle and disorder of glucose homeostasis in juvenile monkeys. Glucose disappearance rate (K(Glu)) and insulin response to the glucose challenge effects in HFHC monkeys were significantly lower than in control monkeys. Otherwise, serum trimethylamine-N-oxide (TMAO), lactate and leucine/isoleucine were significantly higher in HFHC monkeys. Sphingomyelin and choline were the most positively correlated with K(Glu) (R(2) = 0.778), as well as negative correlation (R(2) = 0.64) with total cholesterol. The HFHC diet induced visceral fat, abnormal lipid metabolism and IGT prior to weight gain and body fat content increase in juvenile monkeys. We suggest that increased serum metabolites, such as TMAO, lactate, branched-chain amino acids and decreased sphingomyelin and choline, may serve as possible predictors for the evaluation of IGT and insulin resistance risks in the prediabetic state.

Loading Regenerative Medicine Research Center collaborators
Loading Regenerative Medicine Research Center collaborators