BURLINGAME, CA, United States
BURLINGAME, CA, United States
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Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 208.72K | Year: 2011

DESCRIPTION (provided by applicant): The effectiveness of radiation therapy for lung cancer treatment can be significantly improved if radiation dose can be safely escalated. The main limitation to dose escalation is tumor location uncertainty during treatment due to patient respiration. In addition to geometric changes, tumor hypoxia is a leading cause of treatment failure. If dose can be escalated to radioresistant hypoxic regions then local tumor control would also improve. RefleXion Medical is using positron emission tomography (PET) to guide radiation delivery so that both geometric and biological changes in the tumor can be accounted for in real-time during treatment. In Phase I of the project we aim to: 1) Develop a method of directing radiation beam-lets along individual PET lines-of- response; 2) Develop a method of estimating target position using subsets of PET emissions that occur over a short period of time; and 3) Test methods developed in Aims 1 and 2 using list-mode PET data acquired from a moving phantom. Aim 3 experiments will be accomplished at the Stanford Cancer Center utilizing a motion phantom and a PET-CT system. In Phase II we plan to directly control a multi-leaf collimator using a motion phantom and PET detector table-top system so that tumor tracking can be demonstrated experimentally. The developed treatment methods for real-time PET-guided radiation therapy may result in significantly more effective treatments through safe dose escalation and optimal distribution of the dose to theheterogeneous moving tumor. PUBLIC HEALTH RELEVANCE: Lung cancer is the biggest cancer killer in both men and women in the U.S. While two-thirds of U.S cancer patients are treated with radiation therapy, success rates for lung cancer are low, largely due to movement of the tumor during breathing. In this project, RefleXion Medical aims to develop a radiotherapy system that uses positron emission tomography (PET) to non-invasively track a tumor's position and biological state during treatment. Real-time PET-guided radiotherapy will enable safe dose escalation and smarter dose distribution, leading to more effective treatment of tumors that exhibit significant motion.


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 1.50M | Year: 2014

DESCRIPTION provided by applicant Ablative radiotherapy is a very effective way to non invasively destroy a tumor Tumors in the body however move with respiration and require precise targeting for this high dose treatment There are a variety of technologies that implement tumor tracking to achieve ablative radiotherapy in the body however these are limited to treat just a few lesions in a patient due to the complexity and invasiveness of the necessary motion management techniques Therefore patients that present with later stage disease with more than a few metastatic sites e g lesions are not treatable with ablative radiotherapy RefleXion Medical is developing the first universal method for direct real time targeting of tumors based on biological guidance Utilizing positron emission tomography PET emissions from the patient this new technique allows for continuous and automatic dose conformation to multiple lesions enabling dose escalation to the target s and toxicity reduction to sensitive tissues The concept has been proven with phantom experiments and monte carlo software simulations This proposal has two specific aims to mitigate the key risks in the development of the first clinical prototype hardware system Aim will evaluate the effects that the radiation source or linear accelerator linac system may have on the PET system on a bench top and vice versa Aim will demonstrate simultaneous operation of the linac and PET systems on a closed ring gantry Success of these aims will enable the full clinical prototype to be completed and subsequent commercialization of the first biologically guided radiotherapy system PUBLIC HEALTH RELEVANCE After cancer has metastasized radiosurgery which is a highly effective non invasive method of ablating a tumor is usually no longer an option for the patient due to the complexity of treating many lesions without an easy way to track them during treatment In this project RefleXion Medical aims to develop the first radiotherapy system that uses positron emission tomography PET to non invasively track a tumorandapos s position Biologically guided radiotherapy will enable automatic targeting and tracking of tumors throughout the body enabling radiosurgery treatment for late stage cancer patients


Patent
Reflexion Medical, Inc. | Date: 2016-02-18

Described herein are systems and methods for positioning a radiation source with respect to one or more regions of interest in a coordinate system. Such systems and methods may be used in emission guided radiation therapy (EGRT) for the localized delivery of radiation to one or more patient tumor regions. These systems comprise a gantry movable about a patient area, where a plurality of positron emission detectors, a radiation source are arranged movably on the gantry, and a controller. The controller is configured to identify a coincident positron annihilation emission path and to position the radiation source to apply a radiation beam along the identified emission path. The systems and methods described herein can be used alone or in conjunction with surgery, chemotherapy, and/or brachytherapy for the treatment of tumors.


Patent
Reflexion Medical, Inc. | Date: 2014-05-15

An apparatus comprising a radiation source, coincident positron emission detectors configured to detect coincident positron annihilation emissions originating within a coordinate system, and a controller coupled to the radiation source and the coincident positron emission detectors, the controller configured to identify coincident positron annihilation emission paths intersecting one or more volumes in the coordinate system and align the radiation source along an identified coincident positron annihilation emission path.


Patent
Reflexion Medical, Inc. | Date: 2011-08-12

An apparatus comprising a radiation source, coincident positron emission detectors configured to detect coincident positron annihilation emissions originating within a coordinate system, and a controller coupled to the radiation source and the coincident positron emission detectors, the controller configured to identify coincident positron annihilation emission paths intersecting one or more volumes in the coordinate system and align the radiation source along an identified coincident positron annihilation emission path.


Patent
Reflexion Medical, Inc. | Date: 2016-06-10

Described herein are multi-leaf collimators that comprise leaf drive mechanisms. The leaf drive mechanisms can be used in binary multi-leaf collimators used in emission-guided radiation therapy. One variation of a multi-leaf collimator comprises a pneumatics-based leaf drive mechanism. Another variation of a multi-leaf collimator comprises a spring-based leaf drive mechanism having a spring resonator.


Patent
Reflexion Medical, Inc. | Date: 2015-11-24

An apparatus comprising a radiation source, coincident positron emission detectors configured to detect coincident positron annihilation emissions originating within a coordinate system, and a controller coupled to the radiation source and the coincident positron emission detectors, the controller configured to identify coincident positron annihilation emission paths intersecting one or more volumes in the coordinate system and align the radiation source along an identified coincident positron annihilation emission path.


Patent
Reflexion Medical, Inc. | Date: 2012-03-30

Described herein are systems and methods for positioning a radiation source with respect to one or more regions of interest in a coordinate system. Such systems and methods may be used in emission guided radiation therapy (EGRT) for the localized delivery of radiation to one or more patient tumor regions. These systems comprise a gantry movable about a patient area, where a plurality of positron emission detectors, a radiation source are arranged movably on the gantry, and a controller. The controller is configured to identify a coincident positron annihilation emission path and to position the radiation source to apply a radiation beam along the identified emission path. The systems and methods described herein can be used alone or in conjunction with surgery, chemotherapy, and/or brachytherapy for the treatment of tumors.


Patent
Reflexion Medical, Inc. | Date: 2016-03-14

Described herein are systems and methods for positioning a radiation source with respect to one or more regions of interest in a coordinate system. Such systems and methods may be used in emission guided radiation therapy (EGRT) for the localized delivery of radiation to one or more patient tumor regions. These systems comprise a gantry movable about a patient area, where a plurality of positron emission detectors, a radiation source are arranged movably on the gantry, and a controller. The controller is configured to identify a coincident positron annihilation emission path and to position the radiation source to apply a radiation beam along the identified emission path. The systems and methods described herein can be used alone or in conjunction with surgery, chemotherapy, and/or brachytherapy for the treatment of tumors.


Patent
Reflexion Medical, Inc. | Date: 2013-05-15

An apparatus comprising a radiation source, coincident positron emission detectors configured to detect coincident positron annihilation emissions originating within a coordinate system, and a controller coupled to the radiation source and the coincident positron emission detectors, the controller configured to identify coincident positron annihilation emission paths intersecting one or more volumes in the coordinate system and align the radiation source along an identified coincident positron annihilation emission path.

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