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Diaz-Lopez A.,Rovira i Virgili University | Diaz-Lopez A.,CIBER ISCIII | Bullo M.,Rovira i Virgili University | Bullo M.,CIBER ISCIII | And 21 more authors.
Clinical Nutrition | Year: 2013

Background & aims: The aim was to examine the associations between macronutrient intake and the prevalence of chronic kidney disease (CKD) or microalbuminuria (MiA) in individuals at high cardiovascular risk. Methods: Cross-sectional analyses conducted in 2123 nondiabetic individuals from the PREDIMED study. Dietary data were collected using a food-frequency questionnaire. Analysis of covariance was used to assess associations between quartiles of nutrient intake and estimated glomerular filtration rate (eGFR) or urinary albumin-to-creatinine ratio (ACR). The odds ratio (OR) for the presence of CKD or MiA according to quartiles of nutrient intake was assessed by logistic regression models. Results: Individuals in the highest quartile of n-6 polyunsaturated fatty acid (PUFA) intake showed lower average eGFR. Individuals in the top quartile of fiber intake had a decreased risk of CKD [OR: 0.68; 95% CI: 0.48-0.95]. Conversely, subjects in the highest quartile of n-6 PUFA intake showed an increased risk of CKD [OR: 1.44; 95% CI: 1.03-2.01]. No significant associations were found between the intake of other macronutrients and eGFR, urinary ACR or risk of CKD or MiA. Conclusions: A high fiber intake was associated with a decreased risk of CKD, while a high n-6 PUFA intake was inversely associated with eGFR and directly associated with an increased risk of CKD. © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. Source


Guasch-Ferre M.,Rovira i Virgili University | Guasch-Ferre M.,CIBER ISCIII | Bullo M.,Rovira i Virgili University | Bullo M.,CIBER ISCIII | And 18 more authors.
Journals of Gerontology - Series A Biological Sciences and Medical Sciences | Year: 2013

Background.A Mediterranean-type diet could play a role in decreasing serum uric acid concentrations due to its antioxidant and anti-inflammatory properties. The aim of this study was to evaluate whether better adherence to the Mediterranean diet (MeDiet) reduced or prevented the development of hyperuricemia.Methods.Cross-sectional and prospective analysis in 4,449 elderly participants at high cardiovascular risk from the PREvención con DIeta MEDiterránea trial randomized to two MeDiet interventions (supplemented with either olive oil or nuts) or a control diet. A validated 14-item questionnaire was used to assess adherence to the MeDiet. Hyperuricemia was considered to be present when serum uric acid was higher than 7mg/dL in men or higher than 6mg/dL in women.Results.After a median follow-up of 5 years, 756 individuals of the 3,037 (24.9%) who did not have hyperuricemia at baseline developed hyperuricemia, whereas 422 of the 964 hyperuricemic individuals at baseline (43.8%) reverted this condition. In cross-sectional analyses, an inverse association was observed between increasing levels of adherence to the 14-item MeDiet score and decreasing hyperuricemia (ptrend <. 001). Baseline consumption of red meat, fish and seafood, and wine were associated with a higher prevalence of hyperuricemia. Reversion of hyperuricemia was significantly higher (multivariable-adjusted odds ratio = 1.73; 95% confidence interval: 1.04-2.89) in the highest category of baseline adherence to the MeDiet as compared with the lowest. No association was found between baseline adherence to MeDiet and the incidence of hyperuricemia. The three intervention diets had similar effects in the reduction of hyperuricemia.Conclusions.Higher baseline adherence to the MeDiet is associated with lower risk of hyperuricemia. © 2013 © The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. Source

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