Time filter

Source Type

Virag I.,Reanimatology and Intensive care | Fuduric S.,UHC Zagreb | Mihaljevic S.,UHC Zagreb | Miric V.Z.,UHC Zagreb
Gynaecologia et Perinatologia | Year: 2015

Increasing number of patients, especially females, presenting with a lumbar tattoo, and in need of neuraxial anesthesia, whether in obstetrics or any other surgical branch, has led us to an obvious question: is it safe to puncture through a tattooed skin? „Tissue coring“, a complication of neuraxial anesthesia is the main reason why anesthesiologists are reluctant when facing the lumbar tattoo. Experiments conducted show that tissue coring is a common complication following neuraxial anesthesia, but residual complications following tissue coring are not so frequent. It is much more likely that tissue coring itself is greater problem than tattoo puncture, but long-term analysis was not conducted since it takes many years for complications of this kind to become evident. Nevertheless, it is prudent to take actions to minimize introducing skin tissue, especially pigmented, into spinal space, because of it’s great sensitivity. © 2015, Hrvatsko Drustvo Ginekologa i Opstetricara. All rights reserved.


Glasnovic A.,Clinical Hospital Dubrava | Cvija H.,University of Zagreb | Stojic M.,Clinical Hospital Dubrava | Tudoric Eno I.,Reanimatology and Intensive Care | And 5 more authors.
NeuroImmunoModulation | Year: 2014

Objectives: Receptor for advanced glycation end products (RAGE) ligands/RAGE interactions have been proposed to have a pathogenic role in neuroinflammatory disorders. Our study aimed to assess changes in high-mobility group box (HMGB)1 and its receptor RAGE in peripheral blood (PBL) and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) at the disease onset compared with control subjects. Methods: PBL and CSF were collected from control subjects (n = 30) and MS patients (n = 27) at clinical onset. Soluble RAGE (sRAGE), HMGB1, S100 calcium-binding protein A12 (S100A12), interleukin (IL)-1β and tumor necrosis factor (TNF)- were measured in the CSF and plasma by enzyme-linked immunosorbent assay. Gene expression in PBL mononuclear cells (PBMCs) was detected by quantitative PCR for RAGE, HMGB1, S100A12 and several proinflammatory/immunoregulatory cytokines. Results: We found a significantly lower expression of IL-10 (p = 0.031) in the PBMCs of MS patients. The level of sRAGE in the CSF of MS patients was lower (p = 0.021), with the ability to discriminate between MS patients and control subjects. Moreover, PBMC gene expression for HMGB1 and S100A12 positively correlated with IL-6. Conclusions: Our study confirmed that the cytokine network is disturbed in PBL and CSF at MS clinical onset. The deregulated HMGB1/RAGE axis found in our study may present an early pathogenic event in MS, proposing sRAGE as a possible novel therapeutic strategy for MS treatment. © 2014 S. Karger AG, Basel.


Goluza E.,Reanimatology and Intensive Care | Hudolin T.,KBC Zagreb | Kastelan Z.,KBC Zagreb | Peric M.,Reanimatology and Intensive Care | And 2 more authors.
Urologia Internationalis | Year: 2011

Aims: To investigate analgesia using lidocaine suppositories for prostate biopsy. Methods: From 2007 to 2009, 160 patients underwent transrectal ultrasound-guided prostate biopsy at the Department of Urology, KBC Zagreb. 80 patients received a 60-mg lidocaine suppository intrarectally at different time points from 15 to 120 min before biopsy and 80 patients received a glycerin suppository as placebo. The pain level was evaluated using a visual analogue scale (VAS). Results: There were no statistically significant differences between the groups, i.e. they were similar regarding patients' age, prostate-specific antigen levels, prostate volume and the incidence of diagnosis of malignancy on biopsy. The mean pain score in the lidocaine group (3 ± 1) was significantly lower than the mean pain score in the glycerin group (4.1 ± 1.3) (p < 0.001). A noticeable trend towards lower pain scores in the lidocaine group was observed with more time elapsing from placing the suppository till the biopsy and the optimal time for performing biopsy starting approximately 1 h after placing the suppository. Conclusions: Lidocaine suppositories are an easy-to-use, self-applicable (by the patient) and cheap method of local analgesia, with acceptable results. Possible complications related to this procedure are insignificant. Copyright © 2011 S. Karger AG, Basel.


PubMed | Reanimatology and Intensive Care
Type: Journal Article | Journal: Urologia internationalis | Year: 2011

To investigate analgesia using lidocaine suppositories for prostate biopsy.From 2007 to 2009, 160 patients underwent transrectal ultrasound-guided prostate biopsy at the Department of Urology, KBC Zagreb. 80 patients received a 60-mg lidocaine suppository intrarectally at different time points from 15 to 120 min before biopsy and 80 patients received a glycerin suppository as placebo. The pain level was evaluated using a visual analogue scale (VAS).There were no statistically significant differences between the groups, i.e. they were similar regarding patients age, prostate-specific antigen levels, prostate volume and the incidence of diagnosis of malignancy on biopsy. The mean pain score in the lidocaine group (3 1) was significantly lower than the mean pain score in the glycerin group (4.1 1.3) (p < 0.001). A noticeable trend towards lower pain scores in the lidocaine group was observed with more time elapsing from placing the suppository till the biopsy and the optimal time for performing biopsy starting approximately 1 h after placing the suppository.Lidocaine suppositories are an easy-to-use, self-applicable (by the patient) and cheap method of local analgesia, with acceptable results. Possible complications related to this procedure are insignificant.

Loading Reanimatology and Intensive Care collaborators
Loading Reanimatology and Intensive Care collaborators