Jagadale Sachin K.,Rcpatel Institute Of Pharmaceutical Education And Research |
Patil Pradeep S.,Rcpatel Institute Of Pharmaceutical Education And Research |
Rajini N.,Rcpatel Institute Of Pharmaceutical Education And Research
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013
In the present work, mouth dissolving tablets of losartan potassium were design with a view to enhance the Patient compliance and provide a quick onset of action. Losartan potassium is an angiotensin receptor antagonist, used in the management of hypertension. It has low bioavailability due to its first pass metabolism. Hence the main objective of the study was to formulate mouth dissolving tablets of Losartan potassium to achieve a better dissolution rate and further improving the bioavailability of the drug. Mouth dissolving tablets prepared by direct compression and using super disintegrants like Tulsoin-335 and Tulsion-339 in different concentration and evaluated. The prepared batches of tablets were evaluated for hardness, weight variation, friability, disintegration time and in-vitro dissolution profile and found satisfactory. Among all, the formulation F3 containing Tulsion- 335 in 4% amounts was considered to be best formulation, which showed complete release within 5 min. In the present work, mouth dissolving tablets of Losartan potassium were designed with a view to enhance the patient compliance by using Tulsion-335.
Badgujar V.,Rcpatel Institute Of Pharmaceutical Education And Research |
Surana S.J.,Rcpatel Institute Of Pharmaceutical Education And Research
Journal of Complementary and Integrative Medicine | Year: 2010
Mitragyna parvifolia (Roxb.) Korth (Rubiaceae) is widely used as an acrid, anodyne, bitter, stomachic, febrifuge, and in the treatment of gastropathy, colic, fever, and inflammation. In the present study, the anti-inflammatory and antinociceptive properties of the stem bark methanol extract (MPBM) extracted by Soxhlet extraction and alkaloid rich fraction (MPBAlk) of M. parvifolia was investigated on various animal models. MPBM extract and MPBAlk fraction when tested separately, showed statistically significant (P < 0.01) anti-inflammatory activity by inhibition of percentage rise in paw edema as compared to the control group in a dose dependent manner at different time intervals. When evaluated in acetic acid?induced writings, hot plate and tail flick method in mice, MPBM extract and MPBAlk fraction showed significant analgesic activity at higher dose of 400 mg/kg, whereas activity was moderate at lower dose. These findings suggest that M. parvifolia stem-bark possess significant and dose dependent anti-inflammatory and antinociceptive effects. Chemical analysis shows the presence of alkaloids, flavonoids, glycosides and tannins which may be responsible for these activities. Copyright © 2010 The Berkeley Electronic Press. All rights reserved.
Kulkarni Y.A.,Narsee Monjee Institute of Management and Higher Studies |
Gokhale S.B.,Narsee Monjee Institute of Management and Higher Studies |
Yele S.U.,Narsee Monjee Institute of Management and Higher Studies |
Surana S.J.,Rcpatel Institute Of Pharmaceutical Education And Research |
Tatiya A.U.,Rcpatel Institute Of Pharmaceutical Education And Research
Indian Journal of Natural Products and Resources | Year: 2011
Persea macrantha (Nees) Kosterm (Lauraceae) is an important traditional medicinal plant being used for treatment of asthma and rheumatism. Systematic pharmacognostical evaluation of bark of the plant has been carried out with respect to macroscopy, microscopy, physicochemical parameters and estimation of different standards. TLC profiles were developed for petroleum ether and chloroform extract. The preliminary phytochemical investigations indicated presence of alkaloids, tannins, carbohydrates and steroids. The results obtained from standardization of bark established the macro- and microscopical parameters, physicochemical parameters, TLC profiles that characterize the genuine plant drug (P. macrantha). These parameters can be utilized for quick identification of the drug and are particularly useful in the case of powdered materials.