Rcpatel Institute Of Pharmaceutical Education And Research

Dhule, India

Rcpatel Institute Of Pharmaceutical Education And Research

Dhule, India
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Patil B.S.,Andhra University | Mahajan H.S.,Rcpatel Institute Of Pharmaceutical Education And Research | Surana S.J.,Rcpatel Institute Of Pharmaceutical Education And Research
Journal of Pharmaceutical Investigation | Year: 2016

Flutamide (FLT) is a potent non-steroidal anti-androgen drug primarily used in palliative treatment of prostate cancer that inhibits androgen uptake and/or nuclear binding of androgen in target tissues. The objective of the present study was to prepare FLT mucoadhesive microparticles. FLT mucoadhesive microparticles were developed by ionic gelation technique using hydrophilic polymers such as sodium alginate and Carbopol 971P and optimised by one factorial design of response surface methodology. The optimised microparticles were characterised by zeta potential study, in vitro release study, scanning electron microscopy and X-ray diffraction study. The stability studies performed on the optimized batch at 40 °C/75 % RH for 90 days indicated no significant change in the physicochemical properties. Optimised batch of microparticles was further developed as suppository system using different proportions of Poloxamer 407:Poloxamer 188 as suppository base by fusion method. © 2015, The Korean Society of Pharmaceutical Sciences and Technology.


Jagadale Sachin K.,Rcpatel Institute Of Pharmaceutical Education And Research | Patil Pradeep S.,Rcpatel Institute Of Pharmaceutical Education And Research | Rajini N.,Rcpatel Institute Of Pharmaceutical Education And Research
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

In the present work, mouth dissolving tablets of losartan potassium were design with a view to enhance the Patient compliance and provide a quick onset of action. Losartan potassium is an angiotensin receptor antagonist, used in the management of hypertension. It has low bioavailability due to its first pass metabolism. Hence the main objective of the study was to formulate mouth dissolving tablets of Losartan potassium to achieve a better dissolution rate and further improving the bioavailability of the drug. Mouth dissolving tablets prepared by direct compression and using super disintegrants like Tulsoin-335 and Tulsion-339 in different concentration and evaluated. The prepared batches of tablets were evaluated for hardness, weight variation, friability, disintegration time and in-vitro dissolution profile and found satisfactory. Among all, the formulation F3 containing Tulsion- 335 in 4% amounts was considered to be best formulation, which showed complete release within 5 min. In the present work, mouth dissolving tablets of Losartan potassium were designed with a view to enhance the patient compliance by using Tulsion-335.


Mahajan H.S.,Rcpatel Institute Of Pharmaceutical Education And Research | Gattani S.,Rcpatel Institute Of Pharmaceutical Education And Research
Drug Delivery | Year: 2010

Intranasal (IN) administration is a promising approach for rapid-onset delivery of medications and to circumvent their first-pass elimination when taken orally. Metoclopramide Hydrochloride (MET HCl) is a potent antiemetic, effective even for preventing emesis induced by cancer chemotherapy. The feasibility of developing an efficacious intranasal formulation of metoclopramide has been undertaken in this study. Formulations were modulated so as to have gelation at physiological ion content after intranasal administration. Gelation was determined by physical appearance. The mucoadhesive force in terms of detachment stress, determined using sheep nasal mucosal membrane, increased with increasing concentration of carbopol. The results of in vitro drug permeation studies across sheep nasal mucosa indicate that effective permeation could be significantly increased by using in situ gelling formulation with carbopol concentration 0.15% or greater. Histological examination did not detect any damage during in vitro permeation studies. Finally, the bioavailability study in rabbits revealed that the absolute bioavailability of MET HCl was significantly increased from 40.67% in the case of the oral drug solution to 54.61% in the case of the nasal in situ gel. This study points to the potential of mucoadhesive nasal in situ gel in terms of ease of administration, accuracy of dosing, prolonged nasal residence and improved drug bioavailability. © 2010 Informa UK Ltd.


Tekade A.R.,Rcpatel Institute Of Pharmaceutical Education And Research | Gattani S.G.,Rcpatel Institute Of Pharmaceutical Education And Research
Drug Delivery | Year: 2010

In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Theophylline dual-cross-linked beads were prepared by dropping dispersed phase of theophylline, Delonix regia gum (DRG), and sodium alginate into the dispersion phase of different concentration of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1:2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 57h before release of theophylline from the formulated beads, which were found to be intact for 6h. Thus, formulated dual cross-linked beads when administered at bed time may release theophylline when needed most for chronotherapeutics of early morning asthmatic attacks in chronic patients. In vivo radio imaging study carried out in New Zealand white strain rabbit confirms the findings of in vitro results. © 2010 Informa Healthcare USA, Inc.


Tekade A.R.,Rcpatel Institute Of Pharmaceutical Education And Research | Gattani S.G.,Rcpatel Institute Of Pharmaceutical Education And Research
International Journal of PharmTech Research | Year: 2010

Coating of the dosage forms particularly for pulsatile release plays important role for controlling the lag time prior to release of the drug. In this study, novel natural coating polymeric material was isolated from the seeds of higher plant Delonix regia family-Fabaceae. Isolated polymer was characterized by X-ray diffraction study (XRD), Differential scanning calorimetry (DSC) and Scanning electron microscopy (SEM). Films of this novel polymer were prepared and evaluated for various physical and mechanical properties by tensile tester and bursting strength apparatus. Force, breaking strength, bursting strength and elastic modulus were investigated with respect to the type of polymer and plasticizer used. The prepared films were found to be flexible, had a high strain and burst with only small cracks and was comparable with synthetic polymers which are frequently used for pulsatile as well as sustained release drug delivery system. The microbial flora in the colon degraded the gallactomannan present in the polymer and thus releases the drug in the colon. Therefore, this natural polymer may be a promising candidate for pulsatile drug delivery system which releases the drug at colonic site after a predetermined lag time.


Badgujar V.B.,Rcpatel Institute Of Pharmaceutical Education And Research | Surana S.J.,Rcpatel Institute Of Pharmaceutical Education And Research
Iranian Journal of Pharmacology and Therapeutics | Year: 2011

Aqueous extract and volatile oil were obtained from Miliusa tomentosa by using soxhlet extractor and hydro distillation with a Clevenger-type apparatus respectively. The extract and volatile oil both were nscreened for Antimicrobial activity against different bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Klebsiella pncumoniae, Pseudomonas aeruginosa, Bacillus pumilis) and fungi (Candida albicans, Aspergillusniger, Fusarium monoliforme, Trichoderma viridae, Phanerochaete chrysosporium and Pcilomyces species) by cup plate diffusion method. Minimal Inhibitory Concentration (MIC) values of aqueous extract and volatile oil obtained were determined using modified cup plate method. The aqueous extract exhibited weak activity against all the bacteria and one fungi (Candida albicans), while volatile oil Showed strong activity against most bacteria including Escherichia coli, Bacillus subtilis, Pseudommonas aeruginosa, Klebsiella pneumoni. Also, a moderate activity was seen against Staphylococcus aureus and Bacillus pumilis. It also showed strong activity against fungi like Candida albicans and Fusarium monoli-forme, whereas moderate activity was observed on Aspergillus niger, Trichoderma viridae and the weak activity against the remaining fungi. It can be concluded that Miliusa tomentosa leaf volatile oil finds its use as broad-spectrum antimicrobial agent after extensive investigation, and this may provide a basis for the isolation of constituents of biological interest from Miliusa tomentosa for its potent activity. © 2011 by Razi Institute for Drug Research (RIDR).


Badgujar V.,Rcpatel Institute Of Pharmaceutical Education And Research | Surana S.J.,Rcpatel Institute Of Pharmaceutical Education And Research
Journal of Complementary and Integrative Medicine | Year: 2010

Mitragyna parvifolia (Roxb.) Korth (Rubiaceae) is widely used as an acrid, anodyne, bitter, stomachic, febrifuge, and in the treatment of gastropathy, colic, fever, and inflammation. In the present study, the anti-inflammatory and antinociceptive properties of the stem bark methanol extract (MPBM) extracted by Soxhlet extraction and alkaloid rich fraction (MPBAlk) of M. parvifolia was investigated on various animal models. MPBM extract and MPBAlk fraction when tested separately, showed statistically significant (P < 0.01) anti-inflammatory activity by inhibition of percentage rise in paw edema as compared to the control group in a dose dependent manner at different time intervals. When evaluated in acetic acid?induced writings, hot plate and tail flick method in mice, MPBM extract and MPBAlk fraction showed significant analgesic activity at higher dose of 400 mg/kg, whereas activity was moderate at lower dose. These findings suggest that M. parvifolia stem-bark possess significant and dose dependent anti-inflammatory and antinociceptive effects. Chemical analysis shows the presence of alkaloids, flavonoids, glycosides and tannins which may be responsible for these activities. Copyright © 2010 The Berkeley Electronic Press. All rights reserved.


Kulkarni Y.A.,Narsee Monjee Institute of Management and Higher Studies | Gokhale S.B.,Narsee Monjee Institute of Management and Higher Studies | Yele S.U.,Narsee Monjee Institute of Management and Higher Studies | Surana S.J.,Rcpatel Institute Of Pharmaceutical Education And Research | Tatiya A.U.,Rcpatel Institute Of Pharmaceutical Education And Research
Indian Journal of Natural Products and Resources | Year: 2011

Persea macrantha (Nees) Kosterm (Lauraceae) is an important traditional medicinal plant being used for treatment of asthma and rheumatism. Systematic pharmacognostical evaluation of bark of the plant has been carried out with respect to macroscopy, microscopy, physicochemical parameters and estimation of different standards. TLC profiles were developed for petroleum ether and chloroform extract. The preliminary phytochemical investigations indicated presence of alkaloids, tannins, carbohydrates and steroids. The results obtained from standardization of bark established the macro- and microscopical parameters, physicochemical parameters, TLC profiles that characterize the genuine plant drug (P. macrantha). These parameters can be utilized for quick identification of the drug and are particularly useful in the case of powdered materials.

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