RC Tritec AG

Teufen, Switzerland

RC Tritec AG

Teufen, Switzerland
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Luu V.T.,Novartis | Goujon J.-Y.,Atlanchim Pharma | Meisterhans C.,RC Tritec AG | Frommherz M.,Novartis | Bauer C.,Novartis
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2015

The synthesis of a triple tritiated isotopologue of the CRTh2 antagonist NVP-QAW039 (fevipiprant) with a specific activity >3TBq/mmol is described. Key to the high specific activity is the methylation of a bench-stable dimeric disulfide precursor that is in situ reduced to the corresponding thiol monomer and methylated with [3H3]MeONos having per se a high specific activity. The high specific activity of the tritiated active pharmaceutical ingredient obtained by a build-up approach is discussed in the light of the specific activity usually to be expected if hydrogen tritium exchange methods were applied. Copyright © 2015 John Wiley & Sons, Ltd.


Meisterhans C.,RC TRITEC AG | Nuckel S.C.,RC TRITEC AG | Zeller A.,RC TRITEC AG
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2010

Synthesis and applications of various tritium reagents (tritiated water, tritide reagents, tritiomethyl iodide) for the chemoand regioselective labelling are described and examples of products, which show high specific activities, are presented. Copyright © 2010 John Wiley & Sons, Ltd.


Meisterhans C.,RC TRITEC AG | Nuckel S.C.,RC TRITEC AG | Zeller A.,RC TRITEC AG
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2010

The radiosynthesis group of RC TRITEC is specialised in custom tritium synthesis and therefore has gained a lot of experience in a large variety of different tritium-labelling methods. We present a survey of the projects carried out in the past years focusing on the diverse characteristics and popularities of the different methods. All applied reaction types have been classified into different groups of tritium-labelling methods. These groups are illustrated and discussed with regard to specific activities, regioselective labelling, tritium efficiency, possible labelling candidates and precursors. The varying popularities of the different methods used at RC TRITEC in the past years are statistically analyzed. Copyright © 2010 John Wiley & Sons, Ltd.

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