Rc Patel Institute Pharmaceutical Education And Research

India

Rc Patel Institute Pharmaceutical Education And Research

India

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Patil A.S.,Rc Patel Institute Pharmaceutical Education And Research | Shirkhedkar A.A.,Rc Patel Institute Pharmaceutical Education And Research | Surana S.J.,Rc Patel Institute Pharmaceutical Education And Research | Nawale P.S.,Rc Patel Institute Pharmaceutical Education And Research
Journal of the Chilean Chemical Society | Year: 2012

A simple, rapid and sensitive RP-HPTLC method has been established for the determination of Propranolol hydrochloride (PRH) and Flunarizine Dihydrochloride (FNZ) in bulk and capsule formulation. Separation of both these drugs were achieved on aluminum backed silica gel 60 RP-18 F 254S HPTLC plates, prewashed with methanol using methanol: toluene: ammonia (7:3:0.5 v/v) as mobile phase. Densitometric scanning was performed at 267 nm. The R fvalues for PRH and FNZ were found to be 0.63 and 0.48, respectively. The amount of PRH and FNZ estimated in capsule formulation were found to be 99.20 ± 1.04 and 98.89 ± 1.23, respectively. The accuracy of the method was found to be in the range of 99.30 - 100.41% for PRH and 99.56-100.87 for FNZ. The method was validated as per ICH guidelines and can regularly used for analysis of PRH and FNZ in capsule dosage form.


Patil A.S.,Rc Patel Institute Pharmaceutical Education And Research | Shirkhedkar A.A.,Rc Patel Institute Pharmaceutical Education And Research | Surana S.J.,Rc Patel Institute Pharmaceutical Education And Research | Nawale P.S.,Rc Patel Institute Pharmaceutical Education And Research
Der Pharma Chemica | Year: 2011

Two simple UV-Spectrophotometric methods have been developed for simultaneous determination of Propranolol hydrochloride(PRH) and Flunarizine dihydrochloride(FNZ) in capsule dosage form. Methanol was used as solvent. In Method-I (Q-absorbance absorbance ratio) involves formation of Q-absorbance equation at two wavelengths i.e. 272.8 nm (isoabsorptive point) and 253 nm (λ max of FNZ). While, in Method-II (Multicomponent Mode of Analysis) involves the measurement of absorbance at two wavelengths i.e. 289 nm, λ max of PRH and 253 nm, λ max of FNZ. In both these methods PRH and FNZ followed linearity in the concentration range of 08 - 48 μg/ml for PRH and 03 - 18 μg/mL for FNZ at their respective λ max. Both these methods were found to be accurate, precise and rugged as indicated by low values of % RSD. Both these methods were also found to be rapid and economical can successfully be applied for the routine analysis of PRH and FNZ in bulk and combined capsule dosage form.

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