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Singh S.,Panacea Biotec Pvt. Ltd. | Mohan C.,Rayat Bahra Institute of Pharmacy
European Journal of Medicinal Chemistry | Year: 2014

Within the vast range of heterocycles, benzimidazole and its derivatives are found to be trendy structures employed for discovery of drugs in the field of pharmaceutical and medicinal chemistry. The unique structural features of benzimidazole and a wide range of biological activities of its derivatives made it privileged structure in drug discovery. Recently, benzimidazole scaffold has emerged as a pharmacophore of choice for designing analgesic and anti-inflammatory agents active on different clinically approved targets. To pave the way for future research, there is a need to collect the latest information in this promising area. In the present review we have collated published reports on this versatile core to provide an insight so that its full therapeutic potential can be utilized for the treatment of pain and inflammation. © 2014 Elsevier Masson SAS. All rights reserved. Source

Sharma A.,Rayat Bahra Institute of Pharmacy | Piplani P.,University Institute of Pharmaceutical science
Central Nervous System Agents in Medicinal Chemistry | Year: 2013

In view of the large libraries of acetylcholinesterase inhibitors (AChEIs) that are now being handled in organic synthesis, the identification of drug biological activity is advisable prior to synthesis and this can be achieved by employing predictive biological property methods. In this sense, Quantitative Structure-Activity Relationships (QSAR) or docking approaches have emerged as promising tools. The intention of this review is to summarize the present knowledge concerning computational predictions of AChEIs and AChE. © 2013 Bentham Science Publishers. Source

Sachdeva R.K.,Rayat Bahra Institute of Pharmacy | Kapoor G.,Lovely Professional University
International Journal of Pharma and Bio Sciences | Year: 2013

The present study investigates the effect of crystalline and amorphous carriers for the improvement of dissolution profile of broad spectrum antifungal agent Itraconazole. A comparative study was performed to estimate the ability of Poloxamer-407 (crystalline carrier) and modified Gum Karaya (amorphous carries) for enhancing the dissolution profile of Itraconazole (BCS class II). Solid dispersions prepared (using Poloxamer-407) by hot melt method, exhibited 92% drug release at the end of 2 hrs with good percent yield and percent drug content. While solid dispersions prepared (using modified gum karaya) by solvent evaporation method, exhibited 86% drug release at the end of 2 hrs but it possessed low drug content and low drug yield. Thus, complete amorphous state and absence of crystalline peaks of Itraconazole were observed with Poloxamer-407 while presence of small number of crystalline peaks with much reduced intensity (of Itraconazole) shifting towards lower melting endotherm were observed in case of modified gum karaya. Source

Verma S.,Rayat Bahra Institute of Pharmacy | Jain A.K.,Guru nanak Institute of Pharmacy
Artificial Cells, Nanomedicine and Biotechnology | Year: 2015

Human immunodeciency virus (HIV) infection has become devastating in last a few years. Nearly 7400 new infection cases are coming every day. Highly active antiretroviral therapy (HAART), which involves combination of at least three antiretroviral (ARV) drugs, has been used to extend the life span of the HIV-infected patients. HAART has played an important role to reduce mortality rate in the developed countries but in the developing countries condition is still worst with millions of people being infected by this disease. For the improvement of the situation, nanotechnology-based drug system has been explored for the HIV therapeutics. Nanosystems used for HIV therapeutics offer some unique advantage like enhancement of bioavailability, water solubility, stability, and targeting ability of ARV drugs. Main nanotechnology-based systems explored for HIV therapeutics are liposomes, nanoparticles, niosomes, polymeric micelles, and dendrimers. Present manuscript reviews conventional method of HIV therapeutics and recent advances in the eld of nanotechnology-based systems for treatment of HIV-AIDS. © 2014 Informa Healthcare USA, Inc. Source

Gulati M.,Lovely Professional University | Singh S.K.,Lovely Professional University | Duggal S.,Rayat Bahra Institute of Pharmacy
Journal of Applied Pharmaceutical Science | Year: 2015

Joshanda, a Greco-urban formulation comprising seven herbs has been used since centuries for the treatment of cold, cough and associated allergic reactions. Conventionally, it is used in the form of an extemporaneously prepared decoction. However, in the current scenario, lozenges happen to be the dosage form of choice for antitussive drugs. In case of polyherbal drugs, the dosage form assumes a great importance in order to ensure that all the phyto-components exert their pharmacological effect to the maximum. Based on the popularity of lozenges, conventional decoction form of Joshanda was formulated in the form of lozenges. Lozenges were evaluated for routine quality control tests. The most remarkable feature of the formulation was that excellent compression, hardness, friability and disintegration properties could be achieved without the addition of any external binder. The prepared formulation was subjected to in vitro antioxidant activity, antibacterial activity against common respiratory tract pathogens, in vivo antitussive activity and acute toxicity studies using Albino Wistar mice. Accelerated stability studies were conducted as per ICH guidelines. The performance of lozenges was found to be satisfactory in all the tested aspects. Our study proposes the use of lozenges as a preferred dosage form of the conventionally used decoction of Joshanda. © 2015 Monika Bansal et al. Source

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