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Kumar P.N.V.,Rayalaseema University
Proceedings of 2016 International Conference on Data Mining and Advanced Computing, SAPIENCE 2016 | Year: 2016

Cybercrime also called Computer crime, is any crime that involves a computer and a network. As individuals and businesses increase their reliance on technology, they are exposed to the growing cybercrime threats. Using the computers for our day-to-day transactions is quite common now a days. For example, we pay our life insurance premium, electricity bills, reserve flight or train or bus tickets, order book or any other product online using personal computer, smart phones, public browsing centers etc. The number of users doing online transactions are growing rapidly ever since, because of the convenience it gives to the user to transact business without being physically present in the area where the transaction happens. Criminals committing cybercrime are also growing day-by-day with the increased number of users doing online transactions. Cybercrime covers a wide range of different attacks such as Cyber extortion, Cyber warfare, spreading Computer viruses or Malware, Internet fraud, Spamming, Phishing, carding (fraud), child pornography and intellectual property rights violation etc. Because of increased cyber-attacks these days, the online users must be aware of this kind of attacks and need to cautions while doing online transactions. In this context, the paper will review the growth of cybercrimes in India and measures taken by the government of India to combat the cybercrimes. © 2016 IEEE.

Seshadri R.K.,Dr. Reddys Laboratories Ltd. | Raghavaraju T.V.,Dr. Reddys Laboratories Ltd. | Chakravarthy I.E.,Rayalaseema University
Scientia Pharmaceutica | Year: 2013

A gradient reversed-phase liquid chromatographic (RP-LC) method was developed for the quantitative estimation of impurities in the pharmaceutical dosage form of Omeprazole and Domperidone capsules. The developed method is a stability-indicating test method for the estimation of impurities generated during the formulation and storage of Omeprazole and Domperidone capsules. The chromatographic separation was achieved on a column packed with octadecyl silane, having a column length of 250 mm and diameter of 4.6 mm with a particle size of 5 μm, and by following a gradient program using a combination of a monobasic potassium phosphate buffer (0.05M) and acetonitrile. Since the spectral properties were similar, both compounds' individual impurities were estimated at 285 nm. Forced degradation studies were performed on Omeprazole pellets (enteric coated) and Domperidone pellets (SR coated) encapsulated in size '1' hard gelatin capsules. Omeprazole and Domperidone were degraded using acid hydrolysis (0.1 N hydrochloric acid), base (0.1 N sodium hydroxide), oxidation (50% hydrogen peroxide), heat (105 °C), and UV light (254 nm). The established method was validated and found to be linear, accurate, precise, specific, robust, and rugged. © Seshadri et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria.

Sharma A.V.N.L.,Rayalaseema University | Krishnaiah G.,Rayalaseema University
International Journal of Mechanical and Production Engineering Research and Development | Year: 2017

Estimation, prediction and analysis of responses in turning operation is one of the key research areas. This paper studies the performance of coated inserts (PVD and CVD) in hard machining. In this analysis, 27sets of hard turning experimental trials were performed on a plain turning lathe to study the effect of cutting parameters in influencing the machined surface roughness, material removal rate and power consumption. In all the trials, EN353steel work piece (hardness up to 62 HRC) was machined with commercially available carbide inserts under dry conditions. The machining outcome was used as an input to develop regression models to predict the machined responses on this material. The analysis of this model was used to develop Multi-Objective equation within the specified range of constraints to ascertain the influence of cutting speed, spindle feed and depth of cut to correlate these variables on the stated responses. It was concluded that the multi linear regression model is a choice for prediction of machining responses during machining of EN353 steel (62 HRC) and the results are effective and comparable with Genetic Algorithm (GA) and Artificial Neural Networks (ANN). © TJPRC Pvt. Ltd.

Swarnalathamma B.V.,JB Institute of Engineering and Technology | Krishna M.V.,Rayalaseema University
AIP Conference Proceedings | Year: 2017

We studied heat transfer on MHD convective flow of viscous electrically conducting heat generating/absorbing fluid through porous medium in a rotating channel under uniform transverse magnetic field normal to the channel and taking Hall current. The flow is governed by the Brinkman's model. The diagnostic solutions for the velocity and temperature are obtained by perturbation technique and computationally discussed with respect to flow parameters through the graphs. The skin friction and Nusselt number are also evaluated and computationally discussed with reference to pertinent parameters in detail. © 2017 Author(s).

Polagani S.R.,Rayalaseema University | Polagani S.R.,Wellquest Clinical Research | Pilli N.R.,Wellquest Clinical Research | Gajula R.,Wellquest Clinical Research | Gandu V.,Osmania University
Journal of Pharmaceutical Analysis | Year: 2013

A simple, rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method has been developed and fully validated for the simultaneous quantification of atorvastatin, metformin and glimepiride in human plasma. Carbamazepine was used as internal standard (IS). The analytes were extracted from 200 μL aliquots of human plasma via protein precipitation using acetonitrile. The reconstituted samples were chromatographed on a Alltima HP C18 column by using a 60:40 (v/v) mixture of acetonitrile and 10 mM ammonium acetate (pH 3.0) as the mobile phase at a flow rate of 1.1 mL/min. The calibration curves obtained were linear (r2≥0.99) over the concentration range of 0.50-150.03 ng/mL for atorvastatin, 12.14-1207.50 ng/mL for metformin and 4.98-494.29 ng/mL for glimepiride. The API-4000 LC-MS/MS in multiple reaction monitoring (MRM) mode was used for detection. The results of the intra- and inter-day precision and accuracy studies were well within the acceptable limits. All the analytes were found to be stable in a battery of stability studies. The method is precise and sensitive enough for its intended purpose. A run time of 2.5 min for each sample made it possible to analyze more than 300 plasma samples per day. The developed assay method was successfully applied to a pharmacokinetic study in human male volunteers. © 2012 Xi'an Jiaotong University.

Obulesu M.,Rayalaseema University | Dowlathabad M.R.,Andhra University | Bramhachari P.V.,Krishna University
Neurochemistry International | Year: 2011

Carotenoids play a pivotal role in prevention of many degenerative diseases mediated by oxidative stress including neurodegenerative diseases like Alzheimer's Disease (AD). The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied. This review focuses on the role of carotenoids like retinoic acid (RA), all trans retinoic acid (ATRA), lycopene and β-carotene in prevention of AD symptoms primarily through inhibition of amyloid beta (Aβ) formation, deposition and fibril formation either by reducing the levels of p35 or inhibiting corresponding enzymes. The role of antioxidant micronutrients in prevention or delaying of AD symptoms has been included. This study emphasizes the dietary supplementation of carotenoids to combat AD and warrants further studies on animal models to unravel their mechanism of neuroprotection. © 2011 Elsevier B.V. All rights reserved.

Polagani S.R.,Rayalaseema University | Pilli N.R.,Jawaharlal Nehru University | Gandu V.,Osmania University
Journal of Pharmaceutical Analysis | Year: 2012

A rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method has been developed and fully validated for the simultaneous quantification of pravastatin and aspirin in human plasma. Furosemide was used as an internal standard. Analytes and the internal standard were extracted from human plasma by liquid-liquid extraction technique using methyl tertiary butyl ether. The reconstituted samples were chromatographed on a Zorbax SB-C18 column by using a mixture of 5 mM ammonium acetate buffer and acetonitrile (20:80, v/v) as the mobile phase at a flow rate of 0.8 mL/min. The calibration curve obtained was linear (r≥0.99) over the concentration range of 0.50-600.29 ng/mL for pravastatin and 20.07-2012.00 ng/mL for aspirin. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. A run time of 2.0 min for each sample made it possible to analyze more than 400 human plasma samples per day. The proposed method was found to be applicable to clinical studies. © 2012 Xian Jiaotong University. Production and hosting by Elsevier B.V. All rights reserved.

Vijaya Kumar M.V.,Rayalaseema University | Jamalaiah B.C.,Sri Venkateswara University | Rama Gopal K.,Sri Krishnadevaraya University | Reddy R.R.,Sri Krishnadevaraya University
Journal of Luminescence | Year: 2012

Lead telluroborate (PTBDy) glasses doped with different Dy3 ion concentrations were prepared by melt quenching technique and investigated through optical absorption, fluorescence and decay measurements. The JuddOfelt intensity parameters (λ) are obtained by a least square fit analysis. The small root mean square deviation of ±0.34×10 -6 shows a good fit between the experimental and calculated oscillator strengths. The radiative properties of the 4F 9/2→6H13/2 emission transition of PTBDy10 glass are determined and compared to the other reported glasses. The variation of decay time of the 4F9/2 emission state is attributed to the interaction among the excited Dy3 ions at higher concentration. The PTBDy10 glass is found to be a suitable candidate for solid state laser materials to produce intense yellow (576 nm) luminescence through the 4F9/2→6H13/2 transition. © 2011 Elsevier B.V. All rights reserved.

Kiran P.,Rayalaseema University
Journal of Applied Fluid Mechanics | Year: 2016

The effect of vertical throughflow and time-periodic gravity field has been investigated on Darcy convection. The amplitude of gravity modulation is considered to be very small and the disturbances are expanded in terms of power series of amplitude of convection. A weak nonlinear stability analysis has been performed for the stationary mode of convection. As a consequence heat transport evaluated in terms of the Nusselt number, which is governed by the non-autonomous Ginzburg-Landau equation. Throughflow can stabilize or destabilize the system for stress free and isothermal boundary conditions. The amplitude and frequency of modulation, Prandtl Darcy number on heat transport have been analyzed and depicted graphically. Further, the study establishes that the heat transport can be controlled effectively by a mechanism that is external to the system. Finally flow patterns are presented in terms of streamlines and isotherms.

Kiran P.,Rayalaseema University
Alexandria Engineering Journal | Year: 2016

The effect of vertical throughflow and internal heating effects on fluid saturated porous medium under gravity modulation is investigated. The amplitude of modulation is considered to be very small and the disturbances are expanded in terms of power series of amplitude of convection. A weakly nonlinear stability analysis is proposed to study stationary convection. The Nusselt number is obtained numerically to present the results of heat transfer while using Ginzburg-Landau equation. The vertical throughflow has dual effect either to destabilize or to stabilize the system for downward or upward directions. The effect of internal heat source (Ri>0) enhances or sink (Ri<0) diminishes heat transfer in the system. The amplitude and frequency of modulation have the effects of increasing or diminishing heat transport. For linear model Venezian approach suggested that throughflow and internal heating have both destabilizing and stabilizing effects for suitable ranges of Ω. Further, the study establishes that heat transport can be controlled effectively by a mechanism that is external to the system throughflow and gravity modulation. © 2016 Faculty of Engineering, Alexandria University.

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