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Obulesu M.,Capital Group | Obulesu M.,Rayalaseema University | Rao D.M.,Sri Krishnadevaraya University
Journal of Neurosciences in Rural Practice | Year: 2011

Alzheimer's disease (AD) is a devastative neurodegenerative disorder which needs adequate studies on effective treatment options. The extracts of plants and their effect on the amelioration of AD symptoms have been extensively studied. This paper summarizes the mechanisms like acetylcholinesterase (AChE) inhibition, modification of monoamines, antiamyloid aggregation effect, and antioxidant activity which are actively entailed in the process of amelioration of AD symptoms. These effects are induced by extracts of a few plants of different origin like Yizhi Jiannao, Moringa oleifera (Drumstick tree), Ginkgo Biloba (Ginkgo/Maidenhair tree), Cassia obtisufolia (Sicklepod), Desmodium gangeticum (Sal Leaved Desmodium), Melissa officinalis (Lemon Balm), and Salvia officinalis (Garden sage, common sage).


Polagani S.R.,Rayalaseema University | Pilli N.R.,Jawaharlal Nehru University | Gandu V.,Osmania University
Journal of Pharmaceutical Analysis | Year: 2012

A rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method has been developed and fully validated for the simultaneous quantification of pravastatin and aspirin in human plasma. Furosemide was used as an internal standard. Analytes and the internal standard were extracted from human plasma by liquid-liquid extraction technique using methyl tertiary butyl ether. The reconstituted samples were chromatographed on a Zorbax SB-C18 column by using a mixture of 5 mM ammonium acetate buffer and acetonitrile (20:80, v/v) as the mobile phase at a flow rate of 0.8 mL/min. The calibration curve obtained was linear (r≥0.99) over the concentration range of 0.50-600.29 ng/mL for pravastatin and 20.07-2012.00 ng/mL for aspirin. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. A run time of 2.0 min for each sample made it possible to analyze more than 400 human plasma samples per day. The proposed method was found to be applicable to clinical studies. © 2012 Xian Jiaotong University. Production and hosting by Elsevier B.V. All rights reserved.


Obulesu M.,Rayalaseema University | Dowlathabad M.R.,Andhra University | Bramhachari P.V.,Krishna University
Neurochemistry International | Year: 2011

Carotenoids play a pivotal role in prevention of many degenerative diseases mediated by oxidative stress including neurodegenerative diseases like Alzheimer's Disease (AD). The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied. This review focuses on the role of carotenoids like retinoic acid (RA), all trans retinoic acid (ATRA), lycopene and β-carotene in prevention of AD symptoms primarily through inhibition of amyloid beta (Aβ) formation, deposition and fibril formation either by reducing the levels of p35 or inhibiting corresponding enzymes. The role of antioxidant micronutrients in prevention or delaying of AD symptoms has been included. This study emphasizes the dietary supplementation of carotenoids to combat AD and warrants further studies on animal models to unravel their mechanism of neuroprotection. © 2011 Elsevier B.V. All rights reserved.


Kiran P.,Rayalaseema University | Bhadauria B.S.,Banaras Hindu University
Journal of Heat Transfer | Year: 2016

A study of thermal instability driven by buoyancy force is carried out in an initially quiescent infinitely extended horizontal rotating fluid layer. The temperature at the boundaries has been taken to be time-periodic, governed by the sinusoidal function. A weakly nonlinear stability analysis has been performed for the oscillatory mode of convection, and heat transport in terms of the Nusselt number, which is governed by the complex form of Ginzburg-Landau equation (CGLE), is calculated. The influence of external controlling parameters such as amplitude and frequency of modulation on heat transfer has been investigated. The dual effect of rotation on the system for the oscillatory mode of convection is found either to stabilize or destabilize the system. The study establishes that heat transport can be controlled effectively by a mechanism that is external to the system. Further, the bifurcation analysis also presented and established that CGLE possesses the supercritical bifurcation. Copyright © 2016 by ASME.


Battula S.R.K.,Jawaharlal Nehru Technological University Anantapur | Subbareddy G.V.,Jawaharlal Nehru Technological University Anantapur | Chakravarthy I.E.,Rayalaseema University
Tetrahedron Letters | Year: 2014

An efficient and low cost copper catalyzed system for N-arylation of sulfonimidamides has been developed. The reaction proceeds at room temperature under base free conditions. Various N-aryl, N-heteroaryl, and N-cyclopropyl sulfonimidamides were obtained in good to excellent yields. © 2013 Elsevier Ltd. All rights reserved.

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