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Kumar P.N.V.,Rayalaseema University
Proceedings of 2016 International Conference on Data Mining and Advanced Computing, SAPIENCE 2016 | Year: 2016

Cybercrime also called Computer crime, is any crime that involves a computer and a network. As individuals and businesses increase their reliance on technology, they are exposed to the growing cybercrime threats. Using the computers for our day-to-day transactions is quite common now a days. For example, we pay our life insurance premium, electricity bills, reserve flight or train or bus tickets, order book or any other product online using personal computer, smart phones, public browsing centers etc. The number of users doing online transactions are growing rapidly ever since, because of the convenience it gives to the user to transact business without being physically present in the area where the transaction happens. Criminals committing cybercrime are also growing day-by-day with the increased number of users doing online transactions. Cybercrime covers a wide range of different attacks such as Cyber extortion, Cyber warfare, spreading Computer viruses or Malware, Internet fraud, Spamming, Phishing, carding (fraud), child pornography and intellectual property rights violation etc. Because of increased cyber-attacks these days, the online users must be aware of this kind of attacks and need to cautions while doing online transactions. In this context, the paper will review the growth of cybercrimes in India and measures taken by the government of India to combat the cybercrimes. © 2016 IEEE.


Polagani S.R.,Rayalaseema University | Polagani S.R.,Wellquest Clinical Research | Pilli N.R.,Wellquest Clinical Research | Gajula R.,Wellquest Clinical Research | Gandu V.,Osmania University
Journal of Pharmaceutical Analysis | Year: 2013

A simple, rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method has been developed and fully validated for the simultaneous quantification of atorvastatin, metformin and glimepiride in human plasma. Carbamazepine was used as internal standard (IS). The analytes were extracted from 200 μL aliquots of human plasma via protein precipitation using acetonitrile. The reconstituted samples were chromatographed on a Alltima HP C18 column by using a 60:40 (v/v) mixture of acetonitrile and 10 mM ammonium acetate (pH 3.0) as the mobile phase at a flow rate of 1.1 mL/min. The calibration curves obtained were linear (r2≥0.99) over the concentration range of 0.50-150.03 ng/mL for atorvastatin, 12.14-1207.50 ng/mL for metformin and 4.98-494.29 ng/mL for glimepiride. The API-4000 LC-MS/MS in multiple reaction monitoring (MRM) mode was used for detection. The results of the intra- and inter-day precision and accuracy studies were well within the acceptable limits. All the analytes were found to be stable in a battery of stability studies. The method is precise and sensitive enough for its intended purpose. A run time of 2.5 min for each sample made it possible to analyze more than 300 plasma samples per day. The developed assay method was successfully applied to a pharmacokinetic study in human male volunteers. © 2012 Xi'an Jiaotong University.


Obulesu M.,Rayalaseema University | Dowlathabad M.R.,Andhra University | Bramhachari P.V.,Krishna University
Neurochemistry International | Year: 2011

Carotenoids play a pivotal role in prevention of many degenerative diseases mediated by oxidative stress including neurodegenerative diseases like Alzheimer's Disease (AD). The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied. This review focuses on the role of carotenoids like retinoic acid (RA), all trans retinoic acid (ATRA), lycopene and β-carotene in prevention of AD symptoms primarily through inhibition of amyloid beta (Aβ) formation, deposition and fibril formation either by reducing the levels of p35 or inhibiting corresponding enzymes. The role of antioxidant micronutrients in prevention or delaying of AD symptoms has been included. This study emphasizes the dietary supplementation of carotenoids to combat AD and warrants further studies on animal models to unravel their mechanism of neuroprotection. © 2011 Elsevier B.V. All rights reserved.


Polagani S.R.,Rayalaseema University | Pilli N.R.,Jawaharlal Nehru University | Gandu V.,Osmania University
Journal of Pharmaceutical Analysis | Year: 2012

A rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method has been developed and fully validated for the simultaneous quantification of pravastatin and aspirin in human plasma. Furosemide was used as an internal standard. Analytes and the internal standard were extracted from human plasma by liquid-liquid extraction technique using methyl tertiary butyl ether. The reconstituted samples were chromatographed on a Zorbax SB-C18 column by using a mixture of 5 mM ammonium acetate buffer and acetonitrile (20:80, v/v) as the mobile phase at a flow rate of 0.8 mL/min. The calibration curve obtained was linear (r≥0.99) over the concentration range of 0.50-600.29 ng/mL for pravastatin and 20.07-2012.00 ng/mL for aspirin. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. A run time of 2.0 min for each sample made it possible to analyze more than 400 human plasma samples per day. The proposed method was found to be applicable to clinical studies. © 2012 Xian Jiaotong University. Production and hosting by Elsevier B.V. All rights reserved.


Jamalaiah B.C.,Sri Venkateswara University | Jamalaiah B.C.,Changwon National University | Vijaya Kumar M.V.,Rayalaseema University | Rama Gopal K.,Sri Krishnadevaraya University
Optical Materials | Year: 2011

We report the fluorescence properties of Sm3+-doped lead telluroborate glasses of composition PbF2.TeO2.H 3BO3.Sm2O3 as a function of Sm 3+ concentration. A Judd-Ofelt scheme was used to determine the intensity parameters and radiative properties of Sm3+ ion. The emission and decay measurements were carried out at 402 nm excitation. Beyond 1.0 mol% Sm3+ concentration, the luminescence quenching is observed. The decay curves of 4G5/2 level are well fitted to a single exponential function. The evaluated radiative properties suggest that the 4G5/2 → 6H7/2 transition is responsible for reddish-orange luminescence which might be used in the development of visible lasers. © 2011 Elsevier B.V. All rights reserved.


Vijaya Kumar M.V.,Rayalaseema University | Jamalaiah B.C.,Sri Venkateswara University | Rama Gopal K.,Sri Krishnadevaraya University | Reddy R.R.,Sri Krishnadevaraya University
Journal of Luminescence | Year: 2012

Lead telluroborate (PTBDy) glasses doped with different Dy3 ion concentrations were prepared by melt quenching technique and investigated through optical absorption, fluorescence and decay measurements. The JuddOfelt intensity parameters (λ) are obtained by a least square fit analysis. The small root mean square deviation of ±0.34×10 -6 shows a good fit between the experimental and calculated oscillator strengths. The radiative properties of the 4F 9/2→6H13/2 emission transition of PTBDy10 glass are determined and compared to the other reported glasses. The variation of decay time of the 4F9/2 emission state is attributed to the interaction among the excited Dy3 ions at higher concentration. The PTBDy10 glass is found to be a suitable candidate for solid state laser materials to produce intense yellow (576 nm) luminescence through the 4F9/2→6H13/2 transition. © 2011 Elsevier B.V. All rights reserved.


Kiran P.,Rayalaseema University
Journal of Applied Fluid Mechanics | Year: 2016

The effect of vertical throughflow and time-periodic gravity field has been investigated on Darcy convection. The amplitude of gravity modulation is considered to be very small and the disturbances are expanded in terms of power series of amplitude of convection. A weak nonlinear stability analysis has been performed for the stationary mode of convection. As a consequence heat transport evaluated in terms of the Nusselt number, which is governed by the non-autonomous Ginzburg-Landau equation. Throughflow can stabilize or destabilize the system for stress free and isothermal boundary conditions. The amplitude and frequency of modulation, Prandtl Darcy number on heat transport have been analyzed and depicted graphically. Further, the study establishes that the heat transport can be controlled effectively by a mechanism that is external to the system. Finally flow patterns are presented in terms of streamlines and isotherms.


Kiran P.,Rayalaseema University | Bhadauria B.S.,Banaras Hindu University
Journal of Heat Transfer | Year: 2016

A study of thermal instability driven by buoyancy force is carried out in an initially quiescent infinitely extended horizontal rotating fluid layer. The temperature at the boundaries has been taken to be time-periodic, governed by the sinusoidal function. A weakly nonlinear stability analysis has been performed for the oscillatory mode of convection, and heat transport in terms of the Nusselt number, which is governed by the complex form of Ginzburg-Landau equation (CGLE), is calculated. The influence of external controlling parameters such as amplitude and frequency of modulation on heat transfer has been investigated. The dual effect of rotation on the system for the oscillatory mode of convection is found either to stabilize or destabilize the system. The study establishes that heat transport can be controlled effectively by a mechanism that is external to the system. Further, the bifurcation analysis also presented and established that CGLE possesses the supercritical bifurcation. Copyright © 2016 by ASME.


Battula S.R.K.,Jawaharlal Nehru Technological University Anantapur | Subbareddy G.V.,Jawaharlal Nehru Technological University Anantapur | Chakravarthy I.E.,Rayalaseema University
Tetrahedron Letters | Year: 2014

An efficient and low cost copper catalyzed system for N-arylation of sulfonimidamides has been developed. The reaction proceeds at room temperature under base free conditions. Various N-aryl, N-heteroaryl, and N-cyclopropyl sulfonimidamides were obtained in good to excellent yields. © 2013 Elsevier Ltd. All rights reserved.


Kiran P.,Rayalaseema University
Alexandria Engineering Journal | Year: 2016

The effect of vertical throughflow and internal heating effects on fluid saturated porous medium under gravity modulation is investigated. The amplitude of modulation is considered to be very small and the disturbances are expanded in terms of power series of amplitude of convection. A weakly nonlinear stability analysis is proposed to study stationary convection. The Nusselt number is obtained numerically to present the results of heat transfer while using Ginzburg-Landau equation. The vertical throughflow has dual effect either to destabilize or to stabilize the system for downward or upward directions. The effect of internal heat source (Ri>0) enhances or sink (Ri<0) diminishes heat transfer in the system. The amplitude and frequency of modulation have the effects of increasing or diminishing heat transport. For linear model Venezian approach suggested that throughflow and internal heating have both destabilizing and stabilizing effects for suitable ranges of Ω. Further, the study establishes that heat transport can be controlled effectively by a mechanism that is external to the system throughflow and gravity modulation. © 2016 Faculty of Engineering, Alexandria University.

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