Patri M.,Jawaharlal Nehru University |
Patri M.,Ravenshaw University |
Singh A.,Jawaharlal Nehru University |
Mallick B.N.,Jawaharlal Nehru University
Journal of Neuroscience Research | Year: 2013
Benzo[a]pyrene (B[a]P), a carcinogen, affects brain development, learning, and memory. Isolated studies have reported that B[a]P elevates noradrenaline (NA) level that may modulate neuronal growth, learning, and memory. Therefore, we investigated in vivo and in vitro the effects of B[a]P on learning and memory and its possible mechanism of action. Intracisternal administration of B[a]P on postnatal day 5 significantly reduced learning and memory in adolescent rats as observed by probe test using the Morris water maze. The density of both the subunits of the N-methyl-D-aspartate (NMDA) receptor, NMDAR1 and NMDAR2B, significantly increased in the hippocampus. In vitro, B[a]P significantly increased NMDAR1 in both C6 and Neuro2a cell lines, whereas NMDAR2B was significantly increased in C6 but was significantly decreased in Neuro2a. Pretreatment with NA prevented the B[a]P-induced effect on NMDAR1 expression in both cell lines. However, although NA prevented the B[a]P-mediated increase in NMDAR2B expression in C6, it further potentiated the decrease of NMDAR2B in Neuro2a cells. Also, NA prevented the B[a]P-induced increase in intracellular Ca2+ both in C6 and in Neuro2a. Our findings show that postnatal exposure of developing rats to B[a]P impairs learning and memory even when the rats became adolescent. We also observed that the effects were mediated by elevated intracellular Ca2+ levels and increased expression of NMDAR; furthermore, NA exerted a protective effect by modulating those factors. NA differentially affects neurons and glia, which may have a compensatory role during toxic insults, especially from B[a]P. © 2013 Wiley Periodicals, Inc.
Arakha M.,National Institute of Technology Rourkela |
Saleem M.,National Institute of Technology Rourkela |
Mallick B.C.,Ravenshaw University |
Jha S.,National Institute of Technology Rourkela
Scientific Reports | Year: 2015
The work investigates the role of interfacial potential in defining antimicrobial propensity of ZnO nanoparticle (ZnONP) against different Gram positive and Gram negative bacteria. ZnONPs with positive and negative surface potential are tested against different bacteria with varying surface potentials, ranging -14.7 to -23.6 mV. Chemically synthesized ZnONPs with positive surface potential show very high antimicrobial propensity with minimum inhibitory concentration of 50 and 100 μg/mL for Gram negative and positive bacterium, respectively. On other hand, ZnONPs of the same size but with negative surface potential show insignificant antimicrobial propensity against the studied bacteria. Unlike the positively charged nanoparticles, neither Zn2+ ion nor negatively charged ZnONP shows any significant inhibition in growth or morphology of the bacterium. Potential neutralization and colony forming unit studies together proved adverse effect of the resultant nano-bacterial interfacial potential on bacterial viability. Thus, ZnONP with positive surface potential upon interaction with negative surface potential of bacterial membrane enhances production of the reactive oxygen species and exerts mechanical stress on the membrane, resulting in the membrane depolarization. Our results show that the antimicrobial propensity of metal oxide nanoparticle mainly depends upon the interfacial potential, the potential resulting upon interaction of nanoparticle surface with bacterial membrane. © 2015, Macmillan Publishers Limited. All rights reserved.
Mishra B.K.,Ravenshaw University
Journal of Asian Public Policy | Year: 2016
ABSTRACT: Narendra Modi, who assumed power at the Centre in May 2014 after making a plethora of promises and who is often eulogized as Vikash Purush (the man for development) by the Indian media, has undoubtedly started his innings on an upbeat note and continues to impress the public with his charisma and deft moves. It has been proclaimed that his government’s social policy is premised on the principle of Sabka Saath, Sabka Vikas (collective efforts, inclusive growth), whereby each and every person becomes an important stakeholder in India’s developmental journey. That is, his government seeks to bring collective growth by ensuring collective participation of each individual, group, community and region in the development process. True to its vision of social welfare, this programme has been proactive in its pursuit and has launched a heap of programmes in support of its vision. But a gamut of problems still remains. The reported cases of atrocities on women, unemployment, farmer suicides are only the tip of the iceberg. While optimists commend Modi for all his moves, sceptics tend to question his ability. The moot question remains, how will Modi conquer obstacles to social welfare and succeed in converting rhetoric into reality? © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Das S.K.,Ravenshaw University |
Das S.K.,Defence Institute of High Altitude Research |
Patel B.,Ravenshaw University |
Patri M.,Ravenshaw University
Journal of Toxicology | Year: 2016
Exposure to persistent genotoxicants like benzo[a]pyrene (B[a]P) during postnatal days causes neurobehavioral changes in animal models. However, neurotoxic potential of B[a]P and its association with 6-hydroxydopamine (6-OHDA) induced neurobehavioral changes are yet to be explored. The growth of rat brain peaks at the first week of birth and continues up to one month with the attainment of adolescence. Hence, the present study was conducted on male Wistar rats at postnatal day 5 (PND 5) following single intracisternal administration of B[a]P to compare with neurobehavioral and neurotransmitter changes induced by 6-OHDA at PND 30. Spontaneous motor activity was significantly increased by 6-OHDA showing similar trend following B[a]P administration. Total distance travelled in novel open field arena and elevated plus maze was significantly increased following B[a]P and 6-OHDA administration. Neurotransmitter estimation showed significant alleviation of dopamine in striatum following B[a]P and 6-OHDA administration. Histopathological studies of striatum by hematoxylin and eosin (H&E) staining revealed the neurodegenerative potential of B[a]P and 6-OHDA. Our results indicate that B[a]P-induced spontaneous motor hyperactivity in rats showed symptomatic similarities with 6-OHDA. In conclusion, early postnatal exposure to B[a]P in rats causing neurobehavioral changes may lead to serious neurodegenerative consequences during adolescence. © 2016 Saroj Kumar Das et al.
Biswal S.S.,Ravenshaw University |
Dev P.S.B.,Washington University
Physical Review D | Year: 2017
We show that the longitudinal beam polarization option at a future electron-positron collider provides an unambiguous distinction between low-scale type-I seesaw models of neutrino mass. In particular, the pair production cross section of the heavy neutrinos in seesaw models is shown to be enhanced for a suitable choice of the initial beam polarization, and the choice is governed by the size of the light-heavy neutrino mixing parameter. Using this effect, one can also probe a previously uncharted parameter space of the left-right seesaw model, which is complementary to the existing searches at both energy and intensity frontiers. © 2017 American Physical Society.
Bhanja C.,Utkal University |
Jena S.,Utkal University |
Nayak S.,Ravenshaw University |
Mohapatra S.,Ravenshaw University
Beilstein Journal of Organic Chemistry | Year: 2012
Enantioselective organocatalysis has become a field of central importance within asymmetric chemical synthesis and appears to be efficient approach toward the construction of complex chiral molecules from simple achiral materials in one-pot transformations under mild conditions with high stereocontrol. This review addresses the most significant synthetic methods reported on chiralamine- catalyzed tandem Michael conjugate addition of heteroatom-centered nucleophiles to α,β-unsaturated compounds followed by cyclization reactions for the enantioselective construction of functionalized chiral chromenes, thiochromenes and 1,2-dihydroquinolines in optically enriched forms found in a myriad of bioactive natural products and synthetic compounds. © 2012 Bhanja et al; licensee Beilstein-Institut.
Goswami S.,Ravenshaw University |
Swain B.K.,Utkal University
Journal of Environmental Biology | Year: 2012
The environmental noise in some commercial banks of Balasore, in terms of standard noise indices was worked out in the present study. Noise pollution was assessed in twenty different commercial banks of the city on 31st August, 2010 and during first week of September, 2010. The present noise monitoring was conducted with the help of sound level meter, which was calibrated acoustically using an external reference source, and placed over the microphone. It is inferred that the noise levels were more than the permissible limit i.e. 50 dB as prescribed in USA in all the investigated banks of Balasore and the maximum noise levels were around double of the said permissible limit, which is a contradiction with that of developed countries. Analysis of variance was also computed for all the banks during peak hour (10a.m.-12noon). The mean values of noise levels in different banks ranged from 75.5 to 90dB; from 69 to 83.6dB and 71.5 to 83.5dB during 10a.m.-12noon, 12-2p.m. and 24p.m., respectively. It was categorically observed that noise levels were more during 10a.m.-12noon than other investigated time intervals in all the 20 investigated banks. It is imperative to mention here that such an attempt of assessing noise in banks is first of its kind in India. © Triveni Enterprises.
Mohanty G.,Ravenshaw University |
Ghosh S.N.,Ravenshaw University
Archives of Gynecology and Obstetrics | Year: 2015
Introduction: Cervical cancer is a major health problem of Indian women. It is the second most cancer after breast cancer. In India, every year many women suffer from this cancer because they are illiterate and ignored about cervix cancer severity. As India is a socio-economically backward country of the world, most of the women visiting doctor are from rural areas, they have poor hygienic conditions and many more cervical cancer risk factors. Result: So this review is an attempt to discuss about all of the major risk factors for cervical cancer, screening factors and detection methods for cervical cancer. Conclusion: It aims to keep women of India keeping aside in rural areas informed about cervical cancer severity and its method of detection. © Springer-Verlag Berlin Heidelberg 2014.
Naik S.K.,Ravenshaw University |
Chand P.K.,Utkal University
Plant Cell Reports | Year: 2011
The past 30 years have witnessed a series of systematic biotechnological advances made in pomegranate. These encompass optimization and establishment of in vitro culture techniques including micropropagation, somatic embryogenesis, synthetic seed production, plant regeneration via callus-mediated shoot organogenesis, adventitious shoot regeneration, anther culture, tetraploid induction and genetic transformation. This review attempts to provide a comprehensive account on the tissue culture-mediated biotechnological interventions made in pomegranate aimed at complementing conventional programmes for improvement of this nutraceutically important fruit crop. © 2010 Springer-Verlag.
Mishra P.,Utkal University |
Samanta L.,Ravenshaw University
The Scientific World Journal | Year: 2012
Increased or reduced action of thyroid hormone on certain molecular pathways in the heart and vasculature causes relevant cardiovascular derangements. It is well established that hyperthyroidism induces a hyperdynamic cardiovascular state, which is associated with a faster heart rate, enhanced left ventricular systolic and diastolic function whereas hypothyroidism is characterized by the opposite changes. Hyperthyroidism and hypothyroidism represent opposite clinical conditions, albeit not mirror images. Recent experimental and clinical studies have suggested the involvement of ROS tissue damage under altered thyroid status. Altered-thyroid state-linked changes in heart modify their susceptibility to oxidants and the extent of the oxidative damage they suffer following oxidative challenge. Chronic increase in the cellular levels of ROS can lead to a catastrophic cycle of DNA damage, mitochondrial dysfunction, further ROS generation and cellular injury. Thus, these cellular events might play an important role in the development and progression of myocardial remodeling and heart failure in altered thyroid states (hypo- and hyper-thyroidism). The present review aims at elucidating the various signaling pathways mediated via ROS and their modulation under altered thyroid state and the possibility of antioxidant therapy. Copyright © 2012 Pallavi Mishra and Luna Samanta.