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Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.1.1-3 | Award Amount: 3.21M | Year: 2011

The main objective of the proposed collaborative project Prot-HiSPRA is to remove time-consuming bottlenecks of existing proteomics technologies (sample preparation, fractionation, proteolysis, separation, data collection, and data mining) and bring the proteome driven analysis into time sensitive clinical practice. Prot-HiSPRA is an objective-driven research project and it aims at generating new knowledge and new technologies which will improve the European competitiveness in the field of applied proteomics. Prot-HiSPRA is planned for the duration of 36 months which is necessary in order to ensure a high-quality validation of the developed high-throughput methodologies. A strong participation of SMEs (partner 2 MAYLAB, partner 3 CELS - left the onsortium, partner 6 RTDs, partner 7 - BIA) will ensure strong innovation and exploitation during HiSPRA. Research activities in the Prot-HiSPRA program can be divided into a technological core project that is tailored to significantly improve on technologies in the fields of proteomics, bioinformatics, and integrated biology. Analytical methods developed with the Prot-HiSPRA project will be exemplified by applying for analysis of clinical samples originating from in vitro fertilization (IVF) procedures. During the IVF process, especially at the moment when decisions are made which embryo can be implanted, decisions must be made so that the process has the greatest chance for success. To further elevate pregnancy rates for IVF a non-invasive, rapid, and robust methods for judging the embryos status is urgently needed to examine the embryos proteome. These methods could not only be applied in the described field of reproductive medicine but also in any the other fields of clinical analysis where fast and reliable diagnosis on a proteomic basis could be made available.

Sobolev S.L.,RAS Institute of Problems of Chemical Physics
Acta Materialia | Year: 2013

An abrupt transition from diffusion-limited solidification to diffusionless, kinetic-limited solidification with complete solute trapping is explained as a critical phenomenon which arises due to local non-equilibrium diffusion effects in the bulk liquid. The transition occurs when the interface velocity V passes through the critical point V = VD, where V = V D is the bulk liquid diffusive velocity. Analytical expressions are developed for velocity-temperature and velocity-undercooling functions, using local non-equilibrium partition coefficient based on the Jackson et al. kinetic model and the local non-equilibrium diffusion model of Sobolev. The calculated functions demonstrate a sharp break in the velocity-undercooling and velocity-temperature relationships at the critical point V = VD. At this point the local non-equilibrium solidus and liquidus lines coincide with the T0 temperature. The relationship to pertinent experiments and the influence of the local non-equilibrium diffusion effects on grain refinement and disorder trapping phenomena are discussed. © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Sobolev S.L.,RAS Institute of Problems of Chemical Physics
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2014

An analytical model has been developed to describe the diffusion-viscous stress coupling in the liquid phase during rapid solidification of binary mixtures. The model starts with a set of evolution equations for diffusion flux and viscous pressure tensor, based on extended irreversible thermodynamics. It has been demonstrated that the diffusion-stress coupling leads to non-Fickian diffusion effects in the liquid phase. With only diffusive dynamics, the model results in the nonlocal diffusion equations of parabolic type, which imply the transition to complete solute trapping only asymptotically at an infinite interface velocity. With the wavelike dynamics, the model leads to the nonlocal diffusion equations of hyperbolic type and describes the transition to complete solute trapping and diffusionless solidification at a finite interface velocity in accordance with experimental data and molecular dynamic simulation. © 2013 Elsevier B.V.

Andrievski R.A.,RAS Institute of Problems of Chemical Physics
Physics-Uspekhi | Year: 2014

This paper reviews current research into the behavior of nanostructures under extreme conditions such as high temperatures, irradiation, and deformation. It describes methods for enhancing the stability of nanostructures under these conditions and identifies aspects that have not yet been given sufficient attention. ©2014 Uspekhi Fizicheskikh Nauk, Russian Academy of Sciences

Andrievski R.A.,RAS Institute of Problems of Chemical Physics
Physics-Uspekhi | Year: 2013

This paper reviews the state of the art in metallic nano/microglasses, with a focus on their preparation methods, structure, and physical/mechanical properties. Characterization methods for these glasses are reviewed together with how size effects, temperature variation, and ion irradiation contribute to the increase in their ductility. Some aspects that require more detailed study are identified. © 2013 Uspekhi Fizicheskikh Nauk, Russian Academy of Sciences.

Yurishchev M.A.,RAS Institute of Problems of Chemical Physics
Physical Review B - Condensed Matter and Materials Physics | Year: 2011

The total quantum correlation (discord) in Heisenberg dimers is expressed via the spin-spin correlation function, internal energy, specific heat, or magnetic susceptibility. This allows one to indirectly measure the discord through neutron scattering, as well as calorimetric or magnetometric experiments. Using the available experimental data, we found the discord for a number of binuclear Heisenberg substances with both antiferromagnetic and ferromagnetic interactions. For the dimerized antiferromagnet copper nitrate Cu(NO3)2•2.5H2O, the three independent experimental methods named above lead to a discord of approximately 0.2-0.3 bit/dimer at a temperature of 4 K. We also determined the temperature behavior of discord for hydrated and anhydrous copper acetates, as well as for the ferromagnetic binuclear copper acetate complex [Cu2L(OAc)] •6H2O, where L is a ligand. © 2011 American Physical Society.

Buchachenko A.L.,RAS Institute of Problems of Chemical Physics | Kuznetsov D.A.,RAS Semenov Institute of Chemical Physics | Breslavskaya N.N.,RAS Kurnakov Institute of General and Inorganic Chemistry
Chemical Reviews | Year: 2012

A study was conducted to demonstrate that an isotope provided significant information about chemistry of enzymatic ATP synthesis. Isotope-containing MgCl 2, CaCl 2, and ZnCl 2 samples were obtained using the treatment of magnesium, calcium, and zinc oxides with analytically pure HCl. Monomeric creatine kinase was purified from Vipera xanthia venom, phosphoglycerate kinase was purified from pig skeletal muscle, and pyruvate kinase was isolated and purified from rabbit muscles. The catalytic activities of enzymes were measured conventionally as the amounts of labeled ATP formed in the presence of [ 32P]phosphocreatine, [ 32P] phosphoglycerate, or [ 32P]phosphopyruvate in 1minute at optimal incubation conditions and corrected to 1 mg of tested pure enzyme. The original electrophoretic technique was employed for loading or substitution of magnesium, calcium, and zinc ions into the enzyme active sites.

Sobolev S.L.,RAS Institute of Problems of Chemical Physics
Acta Materialia | Year: 2012

A local non-equilibrium diffusion model (LNDM) for rapid solidification of binary alloys has been briefly reviewed and used to modify a number of solute trapping models with different solid-liquid interface kinetics. The LNDM takes into account deviation from local equilibrium of a solute diffusion field in bulk liquid on the basis that the exact solutions to hyperbolic diffusion equations govern the solute concentration and solute flux in bulk liquid under local non-equilibrium conditions. The LNDM leads to a velocity-dependent effective diffusion coefficient in bulk liquid ahead of the solid-liquid interface DbLNDM(V), which goes to zero when the interface velocity V → V Db, where V Db is the bulk liquid diffusion speed. The results show an abrupt transition from diffusion-limited to purely thermally controlled solidification, with the diffusion coefficient in bulk liquid DbLNDM(V) = 0 and complete solute trapping K LNDM(V) = 1 at a finite interface velocity V = V Db for any type of solid-liquid interface kinetics. The bulk liquid diffusion speed V Db is a critical parameter for the transition. The velocity dependence of partition coefficients K LNDM(V) has been calculated for different types of solid-liquid interface kinetics, with allowance for local non-equilibrium diffusion effects. The calculation shows that the local non-equilibrium partition coefficients K LNDM(V) reduce to the standard K(V) at low interface velocity (V ≪ V Db) and differ substantially at high interface velocity (V ∼ V Db). © 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Lanxess Deutschland GmbH and RAS Institute of Problems of Chemical Physics | Date: 2015-08-12

The present invention relates to the use of 1,2,5-trisubstituted fulleropyrrolidines of formula (1) and their use in optoelectronic devices, preferably in photovoltaic cells, preferably in organic photovoltaic cells to improve the open circuit voltage and energy conversion efficiency of solar cells.

Lanxess Deutschland GmbH and RAS Institute of Problems of Chemical Physics | Date: 2015-02-11

The present invention relates to polymers comprising a conjugated backbone with repeating units represented by formula (I) -[-X-A-X-]-(I)whereinA represents a planar aromatic unit andX in each case independent from each other represents a divalent acetylene fragment or a thiophene unit and the use of theses polymers in photovoltaic devices.

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