Ra's al Khaymah, United Arab Emirates

Ras al-Khaimah Medical and Health Sciences University

Ra's al Khaymah, United Arab Emirates

Ras al-Khaimah Medical and Health science University is a medical university in Ras al-Khaimah, United Arab Emirates. The university was established by the Ras Al Khaimah Human Development Foundation under the leadership of Saud bin Saqr al Qasimi, Crown Prince & Deputy Ruler of Ras Al Khaimah and Chancellor of the University. RAK-HDF is a joint venture of the Ras al-Khaimah Government, Al Ghurair Investments and ETA Ascon Group, Dubai. Wikipedia.

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PubMed | Ibrahim Bin Hamad Obaidullah Hospital and Ras al-Khaimah Medical and Health Sciences University
Type: Journal Article | Journal: International journal of clinical pharmacy | Year: 2016

Background Cephalosporins are one of the most commonly used antibiotics in United Arab Emirates (UAE). Few studies have been carried out to evaluate the antibiotic utilization pattern in UAE in spite of the obvious increase in cephalosporins resistance during the past decade. Objective To assess the prescriptions pattern of cephalosporins among physicians at a secondary care hospital in Ras Al Khaimah, UAE. Method This observational prospective study was carried out during October 2013 to April 2014. The data of in patients were documented in the predesigned patient profile form and was analyzed for patients, drugs and drugs therapy related parameters. Results The 3rd generation cephalosporins constituted 83.6% of the prescriptions, with ceftriaxone being the most commonly used one (81.1%). They were mainly prescribed for the treatment of the lower respiratory tract infections (60.2%). Seven (3.5%) different ADRs linked to cephalosporin use were observed ranging from oral thrush to clostridium difficile infection. A total of 1039 antimicrobial and nonantimicrobial medications were prescribed concomitantly with cephalosporins. Conclusion The 3rd generation cephalosporins were commonly prescribed by parenteral route. Thus, there is a strong need for rationalizing their use to preserve their efficacy and prevent the development of resistance in the region.

PubMed | McGill University, University of Sharjah and Ras al-Khaimah Medical and Health Sciences University
Type: Journal Article | Journal: International dental journal | Year: 2016

The objective of this study was to investigate the opinions of dental students, in one of the dental colleges in the United Arab Emirates (UAE), toward providing tobacco cessation interventions to their patients.Three-hundred-and-fifty students were administered a questionnaire including questions about tobacco cessation interventions (with a response rate of 77%). We generated descriptive statistics for all questions and examined the frequency distribution and percentages of all answers. Data were analysed using cross-tabulations and (2) -tests. The statistical significance was set at P<0.05.While 83.4% of students agreed that dentists should be trained in tobacco cessation, 56% of students disagreed that they are adequately trained to assist the patient in stopping tobacco use. As the year of study increased, the students agree responses increased to the statements that the dentist should be trained and that the dentist has a role in assisting patients to stop smoking. Non-Arab students were more confident than Emiratis in tobacco cessation counselling. The percentage of female students who felt greatly confident in assisting was double that of male students. There was a significant difference between tobacco-user students and non-users in response to the question about dentists role in assisting tobacco cessation.A comprehensive tobacco cessation education and training program should be included in dental schools curriculum in the UAE to further improve student confidence in providing tobacco cessation services to their patients.

Salama R.A.,Cairo University | Salama R.A.,Ras al-Khaimah Medical and Health Sciences University | Labib M.R.,Cairo University
Epidemiology Biostatistics and Public Health | Year: 2016

Background: Anemia is recognised as a major public health problem in developing countries. The prevalence of anemia among school children has received less attention compared to preschoolers and pregnant women. This study aimed to estimate the prevalence of anemia and to identify its associated factors among informal school children in rural Upper Egypt. Methods: A cross sectional descriptive study was conducted in a randomly selected Girls Education Initiative schools in three Egyptian governorates for a duration of 11 months. A structured questionnaire was used to collect sociodemographic data from 2826 children aged 6-19 years. Hemoglobin concentration and anthropometric indicators were assessed using the World Health Organization guidelines. Stool samples were examined for parasitic infestations, using the Kato Katz technique. The objective of the study was adequately explained to participants’ guardian and their consensus was obtained with assured confidentiality. Results: The prevalence of anemia was 59.3%, out of which, 82.5% had mild anemia and 17.4% had moderate anemia. It was significantly higher among 64% of children in the age group 6-9 years and 61.3% of the females. Most of underweight children (75.8%) and 66.4% of children with parasitic infestation were found anemic. Female gender and parasitic infestations were identified as the predicators of anemia among the studied children. Conclusion: Anemia remains a common problem in Girls Education Initiative school particularly among girls of low income household. School children should be screened periodically and appropriate measures should be taken in order to promote health and guide effective education sector reform initiatives. © 2016, Prex S.p.A. All rights reserved.

Sarheed O.,Ras al-Khaimah Medical and Health Sciences University | Abdul Rasool B.K.,Dubai Pharmacy College
Open Biomedical Engineering Journal | Year: 2011

It has now been known for over a decade that low frequency ultrasound can be used to effectively enhance transdermal drug penetration - an approach termed sonophoresis. Mechanistically, acoustic cavitation results in the creation of defects in the stratum corneum that allow accelerated absorption of topically applied molecules. The aim of this study was to develop an optimised sonophoresis protocol for studying transdermal drug delivery in vitro. To this end, caffeine was selected as a model hydrophilic drug while porcine skin was used as a model barrier. Following acoustic validation, 20kHz ultrasound was applied for different durations (range: 5 s to 10 min) using three different modes (10%, 33% or 100% duty cycles) and two distinct sonication procedures (either before or concurrent with drug deposition). Each ultrasonic protocol was assessed in terms of its heating and caffeine flux-enhancing effects. It was found that the best regimen was a concurrent 5 min, pulsed (10% duty cycle) beam of SATA intensity 0.37 W/cm2. A key insight was that in the case of pulsed beams of 10% duty cycle, sonication concurrent with drug deposition was superior to sonication prior to drug deposition and potential mechanisms for this are discussed. © Sarheed and Abdul Rasool; Licensee Bentham Open.

Hayajneh Y.A.,University of Sharjah | AbuAlRub R.F.,Jordan University of Science and Technology | Almakhzoomy I.K.,Ras al-Khaimah Medical and Health Sciences University
International Journal of Nursing Practice | Year: 2010

Adverse events in health care have become an important issue for health-care professionals, administrators, health policy-makers, public and patients. Literature on adverse events in Jordan is scarce. The purpose of the study was (i) to identify the common types and major causes of adverse events in Jordanian hospitals from the nurses' perspective; and (ii) to estimate the frequency of adverse events in Jordanian hospitals. Qualitative and quantitative data regarding the perceived types, causes and incidence of adverse events were collected using a web-based questionnaire. A total of 75 valid responses with qualitative and quantitative data were obtained. The results indicated (i) that medication errors, wrong diagnosis, hospital acquired infections, bed sores and falls were the most common types of adverse events; and (ii) that workload and inadequate staffing, technical performance, negligence and poor ethics, poor management, psychosocial job demands and written guidelines were the most common causes of adverse events. On average, participants in the study believed that adverse events occurred in about 28% of all hospital admissions. Nurse and hospital administrators and health policy-makers should develop and institute effective strategies and polices to prevent or minimize the occurrence of adverse events. © 2010 Blackwell Publishing Asia Pty Ltd.

PubMed | Ras al-Khaimah Medical and Health Sciences University and Al Zahrawi Hospital
Type: Journal Article | Journal: Journal of advanced pharmaceutical technology & research | Year: 2016

United Arab Emirates (UAE) has a high prevalence of hypovitaminosis D. Not much data are available regarding the prevalence of Vitamin D deficiency among multiethnic UAE adult population. (1) To determine the prevalence of hypovitaminosis D in multiethnic UAE population (2) To compare the Vitamin D status in Arab and non-Arab population (3) To identify the demographic variables associated with hypovitaminosis D. It was a retrospective study conducted at a secondary care hospital. Electronic case records of all the subjects who had checked their Vitamin D levels during the time period of May 2010-October 2012 were considered for the study. Vitamin D severe deficiency, deficiency, insufficiency, and sufficiency were defined as serum 25-hydroxy Vitamin D (25(OH)D) levels < 10 ng/mL, 10-20 ng/mL, 21-30 ng/mL, and > 30 ng/mL, respectively. A total 425 subjects were included for the data analysis. Vitamin D deficiency was diagnosed in 208 (48.9%) subjects followed by severe Vitamin D deficiency and insufficiency in 141 (33.2%) and 63 (14.8%) subjects, respectively. The overall prevalence of hypovitaminosis D was 96.9%. Negative association (r = -0.196, P < 0.01) was observed between body mass index (BMI) and 25(OH)D levels. Ethnicity was not (P = 0.103) a predictor of 25(OH)D levels. Majority of our study subjects had Vitamin D deficiency. There was no substantial difference in 25(OH)D levels of different ethnic groups. Female gender, age, and BMI were the predictors 25(OH)D levels.

Al-Azzawi A.M.,Ras al-Khaimah Medical and Health Sciences University
Pakistan Journal of Biological Sciences | Year: 2012

Tecoma stans (Bignoniaceas) is a central and south American tree used for the control of diabetes. This plant is cultivated in Iraq. The dried leaves were soaked in ethanol and water separately for 3 days then filtered and dried. The genotoxic potential of Tecoma stans was studied by in vivo and in vitro system. This study examined the genotoxic activity of aqueous and ethanolic extracts on bone marrow cells from BALB/c mice through evaluation of mitotic index and chromosomal aberrations and cytotoxic effect of the two extracts on Mouse Embryo Fibroblast (MEF) cell line. No alteration in the total number of chromosomal aberrations or the number of cells with chromosomal aberrations observed and percentage of mitotic index at the concentrations tested remained unchanged. The higher concentrations used of the plant extracts had a cytotoxic effect on the MEF cell line. Both extracts had no significant clastogenic effect in vivo but showed cytotoxic effects on mouse embryo in vitro, caution should be exercised in the use of this substance as a medicine. © 2012 Asian Network for Scientific Information.

Nanaware D.A.,Bharati Vidyapeeth Deemed University | Bhusari V.K.,Bharati Vidyapeeth Deemed University | Dhaneshwar S.R.,Ras al-Khaimah Medical and Health Sciences University
International Journal of Pharmacy and Technology | Year: 2012

Aims: The paper describes an HPTLC method for the simultaneous determination of Omeprazole and Dicyclomine Hydrochloride from tablet dosage forms. Method: This employs a precoated silica gel 60 F 254 (0.2 mm thickness) plate on aluminium sheets and a mobile phase toluene: acetone: methanol: ammonia in the ratio of (7: 1.5: 1: 0.1) (v/v/v/v), having chamber saturation for 40 min at room temperature. The mobile phase was run upto 8 cm. The plate was scanned and quantified at 345 nm for both Omeprazole and Dicyclomine Hydrochloride. Result: The R F values were found to be 0.34 ± 0.02 and 0.76 ± 0.02 for Omeprazole and Dicyclomine Hydrochloride, respectively. The linear detector response was observed between 400-2400 ng/spot and 500-3000 ng/spot for Omeprazole and Dicyclomine Hydrochloride, respectively. The developed method was validated for accuracy (99.45 ± 0.54 % and 99.86 ± 0.44 %) for Omeprazole and Dicyclomine Hydrochloride, respectively, Precision (intra-day RSD 0.56-1.13 % and inter-day RSD 0.76-1.10 % for Omeprazole and intra-day RSD 1.08- 1.21 % and inter-day RSD 1.15-1.19 % for Dicyclomine Hydrochloride, respectively). The recovery was carried out by standard addition method. The average recovery was found to be 100.27 % and 99.91 % for Omeprazole and Dicyclomine Hydrochloride, respectively. Conclusion: The proposed HPTLC method is less expensive, simpler, rapid and is more flexible than the reported methods.

PubMed | Ras al-Khaimah Medical and Health Sciences University
Type: Journal Article | Journal: Applied immunohistochemistry & molecular morphology : AIMM | Year: 2016

Prolactin (PRL) hormone plays an important role in the development of the mammary gland and terminal differentiation of the mammary epithelial cells. While initial studies suggested that PRL may contribute to the development of breast cancer through PRL/prolactin receptor (PRLR) autocrine function, mounting evidence indicate a different role for PRL, highlighting this hormone as a regulator of epithelial plasticity and as a potential tumor suppressor. To gain further insights into the role of PRL in human breast carcinogenesis, immunohistochemistry analyses of PRLR protein expression levels using tissue microarray of 102 cases were done in comparison with various clinical/pathologic parameters and molecular subtypes. In addition, gene expression level of PRLR was also evaluated in relation to intrinsic molecular subtypes, tumor grade, and patient outcome using GOBO database for 1881 breast cancer patients. Interestingly, PRLR expression was found to be significantly downregulated in invasive breast cancer (21.4%) in comparison with normal/benign (80%) and in situ carcinoma (60%) (P=0.003498). Moreover, PRLR expression was associated with lymph node negativity and low-grade well-differentiated tumors. PRLR expression was strongest in luminal A subtype, and was virtually undetectable in the worse prognosis triple-negative breast cancer subtype (P=0.00001). Furthermore, PRLR expression was independent of ER, PR, HER-2, and P53 status. Finally, PRLR expression was significantly (P<0.01) associated with prolonged distant metastasis-free survival in breast cancer patients. In conclusion, our results highlight PRLR as an independent predictor of favorable prognosis in human breast cancer.

PubMed | Ras al-Khaimah Medical and Health Sciences University
Type: Review | Journal: Avicenna journal of medicine | Year: 2016

To study and critically analyze the published evidence on correlation of hormonal abnormalities and endothelial dysfunction (ED) in polycystic ovary syndrome (PCOS) through a systematic review. The databases including MEDLINE, PubMed, Up-To-Date, and Science Direct were searched using Medical subject handling terms and free text term keywords such as endocrine abnormalities in PCOS, ED assessment in PCOS, ED in combination with insulin resistance (IR), hyperandrogenism (HA), increased free testosterone, free androgen index (FAI), gonadotrophin levels, luteinizing hormone (LH), prolactin, estrogen, adipocytokines to search trials, and observational studies published from January 1987 to September 2015. Authors of original studies were contacted for additional data when necessary. PCOS increases the risk of cardiovascular disease in women. ED, which is a reliable indicator of cardiovascular risk in general population, is seen in most (but not all) women with PCOS. IR, seen in 70% patients with PCOS, is associated with ED in these women, but patients can have normal endothelial function even in the presence of IR. Free testosterone and FAI are consistently associated with ED, but endothelial function can be normal despite HA. Estradiol (not estrone) appears to be protective against ED though estrone is the predominant estrogen produced in PCOS. Increased levels of adipocytokines (visfatin) are promising in predicting ED and cardiovascular risk. However, more studies are required focusing on direct correlation of levels of prolactin, LH, estrone, and visfatin with ED in PCOS.

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