Ra's al Khaymah, United Arab Emirates

Ras al-Khaimah Medical and Health Sciences University

Ra's al Khaymah, United Arab Emirates

Ras al-Khaimah Medical and Health science University is a medical university in Ras al-Khaimah, United Arab Emirates. The university was established by the Ras Al Khaimah Human Development Foundation under the leadership of Saud bin Saqr al Qasimi, Crown Prince & Deputy Ruler of Ras Al Khaimah and Chancellor of the University. RAK-HDF is a joint venture of the Ras al-Khaimah Government, Al Ghurair Investments and ETA Ascon Group, Dubai. Wikipedia.

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Dhaneshwar S.R.,Ras al-Khaimah Medical and Health Sciences University
Der Pharmacia Lettre | Year: 2013

Twenty chalcones were prepared by grinding equimolar quantities of (hetero) aryl methyl ketone with (hetero) aryl aldehyde in presence of sodium hydroxide in solvent free condition. Such an attempt has not yet been made or available for the synthesis of heterocyclic chalcones mentioned in this work. The synthesis was found to be simple, efficient in terms of short reaction time, excellent yields and afford single product as indicated in TLC. The synthesized compounds were characterized by means of their IR, 1H NMR spectral data and elemental analysis. This method may be a promising alternative to the conventional methods.

Rasool B.K.A.,Dubai Pharmacy College | Aziz U.S.,University of Basrah | Sarheed O.,Ras al-Khaimah Medical and Health Sciences University | Rasool A.A.A.,University of Baghdad
Acta Pharmaceutica | Year: 2011

The objective of the study was to develop a suitable trans-dermal delivery system for propranolol hydrochloride (PPL) via employing chitosan as a film former. Drug concentration uniformity, thickness, moisture uptake capacity and skin bioadhesion of the films were characterized. The effects of chitosan and PPL concentration and different penetration enhancers on the release and permeation profiles from the films were investigated. Skin irritation of the candidate film was evaluated. Chitosan film (PPL 2 mg cm-2, chitosan 2 %, m/m, cineol 10 %, m/m) was found nonirritant and achieved 88.2 % release after 8 hours in phosphate buffer. Significant high (p < 0.001) permeation of PPL through rat skin was obtained using this film compared to the film without enhancer (about 8 times enhancement factor), making it a promising trans-dermal delivery system for PPL.

Usman S.,University of Karachi | Akram M.,University of Karachi | Aziz A.,University of Karachi | Ramesh V.,Ras al-Khaimah Medical and Health Sciences University | Sarheed O.A.,Ras al-Khaimah Medical and Health Sciences University
Pakistan journal of pharmaceutical sciences | Year: 2014

The aim of the present study was to develop and validate an analytical method for the estimation of nepafenac as a raw material as well as in dosage form (suspension) by using reverse phase high performance liquid chromatographic (RP-HPLC). The target was to obtain an easy, rapid, reproducible as well as a rugged method. The HPLC system that was used in the proposed study was LC-20AD liquid chromatograph equipped with SPD-20A UV-VIS detector. The separation was performed on C18 column which was attached with loop 20 β l. Elution was done at ambient temperature with a mobile phase consisting of acetonitrile: Water (40: 60v/v) at a flow rate of 1ml/min and at a wavelength of 254 nm. The proposed method was validated as per the ICH guidelines. The retention time for nepafenac was 7.49 minutes (% CV=0.0076). The percentage coefficient variation (CV) of six consecutive peak areas of injections was 0.34% with tailing factor 1.76. The peak area responses were linear within the concentration range of 0.078-20.0 βg/ml (R(2)=0.9993). The sensitivity of the method could be evaluated by limits of detection (LOD) (0.0195 β g/ml) and limits of quantitation (LOQ) (0.039 β g/ml). Nepafenac drug is s in its diluent that could see by intra-day (% CV =0.45-1.96) and inter-day variation (%CV=0.173-1.898%). The accuracy and recovery results of 80%, 100% and 120% were 97.40% to 102.10% with % CV of 0.3201% to 1.3496%. The robustness and ruggedness of the method are significantly broader and is reproducible. It could be used as a more convenient, efficient, easy and time saving method for the analysis of drug in raw material as well as in dosage form (ophthalmic suspension).

Al-Azzawi A.M.,United Arab Emirates University | Al-Khateeb E.,Al-Ahliyya Amman University | Al-Sameraei K.,Nahrain University | Al-Juboori A.G.,Ras al-Khaimah Medical and Health Sciences University
Pharmacognosy Research | Year: 2012

Background: Tecoma stans (Bignoniaceae) is a central and south American tree used for the control of diabetes, also known as Yellow Elder, it was collected from the gardens of Al-Jadria in Iraq. Materials and Methods: One of the main reported alkaloidal constituents, tecomine, was isolated and confirmed by spectral analysis. The bacteriological assay for different plant leaves extracts; aqueous, ethanolic, and isolated tecomine were conducted to evaluate the antibacterial effect against gram-negative and gram-positive bacteria. Results: Whole alcoholic and aqueous extract exhibited the antibacterial activity and isolated tecomine. Histopathological evaluation was demonstrated on the liver, spleen, and pancreas of the BALB/c mice given the whole alcoholic and aqueous extract that showed no significant changes in the organ texture. Conclusion: Biochemical analysis of the serum obtained showed decrease in the glucose level in the mice treated with plant extract at the most two higher concentrations used with no change in the cholesterol and triglyceride level.

PubMed | McGill University, University of Sharjah and Ras al-Khaimah Medical and Health Sciences University
Type: Journal Article | Journal: International dental journal | Year: 2016

The objective of this study was to investigate the opinions of dental students, in one of the dental colleges in the United Arab Emirates (UAE), toward providing tobacco cessation interventions to their patients.Three-hundred-and-fifty students were administered a questionnaire including questions about tobacco cessation interventions (with a response rate of 77%). We generated descriptive statistics for all questions and examined the frequency distribution and percentages of all answers. Data were analysed using cross-tabulations and (2) -tests. The statistical significance was set at P<0.05.While 83.4% of students agreed that dentists should be trained in tobacco cessation, 56% of students disagreed that they are adequately trained to assist the patient in stopping tobacco use. As the year of study increased, the students agree responses increased to the statements that the dentist should be trained and that the dentist has a role in assisting patients to stop smoking. Non-Arab students were more confident than Emiratis in tobacco cessation counselling. The percentage of female students who felt greatly confident in assisting was double that of male students. There was a significant difference between tobacco-user students and non-users in response to the question about dentists role in assisting tobacco cessation.A comprehensive tobacco cessation education and training program should be included in dental schools curriculum in the UAE to further improve student confidence in providing tobacco cessation services to their patients.

Salama R.A.,Cairo University | Salama R.A.,Ras al-Khaimah Medical and Health Sciences University | Labib M.R.,Cairo University
Epidemiology Biostatistics and Public Health | Year: 2016

Background: Anemia is recognised as a major public health problem in developing countries. The prevalence of anemia among school children has received less attention compared to preschoolers and pregnant women. This study aimed to estimate the prevalence of anemia and to identify its associated factors among informal school children in rural Upper Egypt. Methods: A cross sectional descriptive study was conducted in a randomly selected Girls Education Initiative schools in three Egyptian governorates for a duration of 11 months. A structured questionnaire was used to collect sociodemographic data from 2826 children aged 6-19 years. Hemoglobin concentration and anthropometric indicators were assessed using the World Health Organization guidelines. Stool samples were examined for parasitic infestations, using the Kato Katz technique. The objective of the study was adequately explained to participants’ guardian and their consensus was obtained with assured confidentiality. Results: The prevalence of anemia was 59.3%, out of which, 82.5% had mild anemia and 17.4% had moderate anemia. It was significantly higher among 64% of children in the age group 6-9 years and 61.3% of the females. Most of underweight children (75.8%) and 66.4% of children with parasitic infestation were found anemic. Female gender and parasitic infestations were identified as the predicators of anemia among the studied children. Conclusion: Anemia remains a common problem in Girls Education Initiative school particularly among girls of low income household. School children should be screened periodically and appropriate measures should be taken in order to promote health and guide effective education sector reform initiatives. © 2016, Prex S.p.A. All rights reserved.

Sarheed O.,Ras al-Khaimah Medical and Health Sciences University | Abdul Rasool B.K.,Dubai Pharmacy College
Open Biomedical Engineering Journal | Year: 2011

It has now been known for over a decade that low frequency ultrasound can be used to effectively enhance transdermal drug penetration - an approach termed sonophoresis. Mechanistically, acoustic cavitation results in the creation of defects in the stratum corneum that allow accelerated absorption of topically applied molecules. The aim of this study was to develop an optimised sonophoresis protocol for studying transdermal drug delivery in vitro. To this end, caffeine was selected as a model hydrophilic drug while porcine skin was used as a model barrier. Following acoustic validation, 20kHz ultrasound was applied for different durations (range: 5 s to 10 min) using three different modes (10%, 33% or 100% duty cycles) and two distinct sonication procedures (either before or concurrent with drug deposition). Each ultrasonic protocol was assessed in terms of its heating and caffeine flux-enhancing effects. It was found that the best regimen was a concurrent 5 min, pulsed (10% duty cycle) beam of SATA intensity 0.37 W/cm2. A key insight was that in the case of pulsed beams of 10% duty cycle, sonication concurrent with drug deposition was superior to sonication prior to drug deposition and potential mechanisms for this are discussed. © Sarheed and Abdul Rasool; Licensee Bentham Open.

Hayajneh Y.A.,University of Sharjah | AbuAlRub R.F.,Jordan University of Science and Technology | Almakhzoomy I.K.,Ras al-Khaimah Medical and Health Sciences University
International Journal of Nursing Practice | Year: 2010

Adverse events in health care have become an important issue for health-care professionals, administrators, health policy-makers, public and patients. Literature on adverse events in Jordan is scarce. The purpose of the study was (i) to identify the common types and major causes of adverse events in Jordanian hospitals from the nurses' perspective; and (ii) to estimate the frequency of adverse events in Jordanian hospitals. Qualitative and quantitative data regarding the perceived types, causes and incidence of adverse events were collected using a web-based questionnaire. A total of 75 valid responses with qualitative and quantitative data were obtained. The results indicated (i) that medication errors, wrong diagnosis, hospital acquired infections, bed sores and falls were the most common types of adverse events; and (ii) that workload and inadequate staffing, technical performance, negligence and poor ethics, poor management, psychosocial job demands and written guidelines were the most common causes of adverse events. On average, participants in the study believed that adverse events occurred in about 28% of all hospital admissions. Nurse and hospital administrators and health policy-makers should develop and institute effective strategies and polices to prevent or minimize the occurrence of adverse events. © 2010 Blackwell Publishing Asia Pty Ltd.

Al-Azzawi A.M.,Ras al-Khaimah Medical and Health Sciences University
Pakistan Journal of Biological Sciences | Year: 2012

Tecoma stans (Bignoniaceas) is a central and south American tree used for the control of diabetes. This plant is cultivated in Iraq. The dried leaves were soaked in ethanol and water separately for 3 days then filtered and dried. The genotoxic potential of Tecoma stans was studied by in vivo and in vitro system. This study examined the genotoxic activity of aqueous and ethanolic extracts on bone marrow cells from BALB/c mice through evaluation of mitotic index and chromosomal aberrations and cytotoxic effect of the two extracts on Mouse Embryo Fibroblast (MEF) cell line. No alteration in the total number of chromosomal aberrations or the number of cells with chromosomal aberrations observed and percentage of mitotic index at the concentrations tested remained unchanged. The higher concentrations used of the plant extracts had a cytotoxic effect on the MEF cell line. Both extracts had no significant clastogenic effect in vivo but showed cytotoxic effects on mouse embryo in vitro, caution should be exercised in the use of this substance as a medicine. © 2012 Asian Network for Scientific Information.

Nanaware D.A.,Bharati Vidyapeeth Deemed University | Bhusari V.K.,Bharati Vidyapeeth Deemed University | Dhaneshwar S.R.,Ras al-Khaimah Medical and Health Sciences University
International Journal of Pharmacy and Technology | Year: 2012

Aims: The paper describes an HPTLC method for the simultaneous determination of Omeprazole and Dicyclomine Hydrochloride from tablet dosage forms. Method: This employs a precoated silica gel 60 F 254 (0.2 mm thickness) plate on aluminium sheets and a mobile phase toluene: acetone: methanol: ammonia in the ratio of (7: 1.5: 1: 0.1) (v/v/v/v), having chamber saturation for 40 min at room temperature. The mobile phase was run upto 8 cm. The plate was scanned and quantified at 345 nm for both Omeprazole and Dicyclomine Hydrochloride. Result: The R F values were found to be 0.34 ± 0.02 and 0.76 ± 0.02 for Omeprazole and Dicyclomine Hydrochloride, respectively. The linear detector response was observed between 400-2400 ng/spot and 500-3000 ng/spot for Omeprazole and Dicyclomine Hydrochloride, respectively. The developed method was validated for accuracy (99.45 ± 0.54 % and 99.86 ± 0.44 %) for Omeprazole and Dicyclomine Hydrochloride, respectively, Precision (intra-day RSD 0.56-1.13 % and inter-day RSD 0.76-1.10 % for Omeprazole and intra-day RSD 1.08- 1.21 % and inter-day RSD 1.15-1.19 % for Dicyclomine Hydrochloride, respectively). The recovery was carried out by standard addition method. The average recovery was found to be 100.27 % and 99.91 % for Omeprazole and Dicyclomine Hydrochloride, respectively. Conclusion: The proposed HPTLC method is less expensive, simpler, rapid and is more flexible than the reported methods.

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