Rao P.V.R.,RARS |
Anuradha G.,Institute of Biotechnology |
Shankar V.G.,RARS |
Reddy K.R.,RARS |
And 2 more authors.
Archives of Phytopathology and Plant Protection | Year: 2012
Powdery mildew is a devastating disease in sesame during rabi season, causing considerable yield loss. Utilisation of host plant resistance mechanism is ideal disease management strategy and knowledge of inheritance of tolerance/resistance to powdery mildew will be quite helpful in formulating breeding program. In the present investigation, 30 genotypes were screened against powdery mildew, of which 18 showed susceptible and 12 tolerant reactions. None of the genotype recorded immune response. Study on inheritance of tolerance to powdery mildew revealed that susceptibility was dominant over tolerance and is controlled by two independent recessive genes with complementary epistasis. © 2012 Copyright Taylor and Francis Group, LLC.
Singh P.,MPUAT |
Kubsad V.S.,UAS |
Kalpana R.,TNAU |
Alse U.N.,VNMKV |
Indian Journal of Agronomy | Year: 2015
Field experiments were conducted under All India Coordinated Sorghum Improvement Project (AICSIP) at 6 locations during rainy seasons of 2009 and 2010 in a split plot design having 3 fertility levels, viz., control (0:0:0 kg/ ha of N: P2 O5 :K2 O), recommended dose of nutrients-RDF (80:40:40 kg/ha of N: P2 O5 : K2 O) and 150% of RDF (120:60:60 kg/ha of N: P2 O5 : K2 O) in main-plots, while 8 sorghum cultivars including 3 hybrids (‘CSH 14’, ‘CSH 16’, ‘CSH 23’) and 5 varieties (‘SPV 462’, ‘CSV 15’, ‘CSV 17’, ‘CSV 23’, ‘SPV 1616’) constituted the sub-plot to find out their effects on productivity and nutrient-use efficiency in rainy-season grain sorghum [Sorghum bicolor (L.) Moench]. Results revealed that increasing levels of fertility up to 150% RDF significantly increased the grain yield (3.28 t/ha), nutrient uptake, net returns (25.97 ×103 /ha) and benefit: cost ratio (1.79) as compared to control. Hybrids produced 20.6% higher grain yield over varieties. Among hybrids ‘CSH 16’ (3.07 t/ha) and among varieties ‘SPV 462’ (2.56 t/ha) produced the maximum grain yields. The nutrient-use efficiency (NUE) was higher in hybrids (6.66 kg grain/kg NPK) than the varieties (5.54 kg grain/kg NPK). Increasing fertility levels from 100% RDF to 150% RDF increased the NUE of all the test hybrids, but decreased the efficiency of varieties except ‘CSV 17’. © 2015 Indian Society of Agronomy. All rights reserved.
Devaranavadgi S.B.,Regional Agricultural Research Station |
Patil S.B.,Regional Agricultural Research Station |
Kambrekar D.N.,RARS |
Jambagi M.B.,Regional Agricultural Research Station
International Journal of Agricultural and Statistical Sciences | Year: 2010
Field experiment was conducted for two year in Northern dry zone of Karnataka to study the light transmission ratio (LTR), soil moisture, N content and uptake in rabi sorghum as influenced by root pruning depth and coppicing height of G. sepium in alley cropping system. The results showed that root pruning at 45 cm depth and coppicing at 20 cm recorded significantly higher LTR and soil moisture content in different growth stages of rabi sorghum. However, N content in soil after harvest of rabi sorghum did not influenced by root pruning depth and copping height, but N uptake by rabi sorghum was significantly influenced by root pruning depth and coppicing height. The maximum uptake of N was found with root pruning at 45 cm depth and 5 cm coppicing height (41.29 and 40.08 kg ha-1 respectively). The interaction between depth of root pruning and coppicing height was found to be non significant.
Opsona Therapeutics Ltd. Announces Preliminary Results from Ongoing Study in Second Line Lower Risk Myelodysplastic Syndrome MDS Recently Presented at the 58th Annual Meeting of the American Society of Hematology ASH
News Article | December 20, 2016
DUBLIN--(BUSINESS WIRE)--Opsona Therapeutics Ltd (‘Opsona’), the innate immune drug development company focused on novel therapeutic approaches to treat oncology, autoimmune and other inflammatory diseases, today announces the preliminary results from its ongoing prospective, open label Phase I/II study being conducted with OPN-305 in second-line lower (Low and intermediate-1) risk myelodysplastic syndrome (MDS) which created interest when presented recently at the 58th Annual Meeting of the American Society of Hematology (ASH) in San Diego by Prof Garcia-Manero from the MD Anderson Cancer Center. OPN-305 is a novel proprietary humanized IgG4 monoclonal antibody (MAb) against Toll-Like Receptor 2 (TLR2), a key target within the innate immune system. Opsona has recently received orphan drug designation from the United States Food and Drug Administration for MDS. The study in patients with lower risk, red cell transfusion dependent, MDS who have failed hypomethylating agents (HMA) ± an erythropoiesis stimulating agent is ongoing in collaboration with MD Anderson Cancer Center in Houston USA with additional sites now being added in the USA. As of December 2016, 24 eligible patients have been enrolled, 11 at 5 mg dose and 13 at 10 mg/kg. A total of 15 (75%) patients are evaluable for response. Hematological improvement has been seen in 53% (8/15) with 3 (20%) patients achieving transfusion independence and of these 2/5 (40%) were receiving 10 mg/kg while on OPN-305 monotherapy. 12 patients remain on study. Median age was 72 years (range 42-87). Nine (43 %) patients were classified as Low risk and 15 (63%) as Intermediate-1 risk by IPSS. Thirteen patients (61%) had diploid cytogenetics, 8 (38%) RAEB,5 (23%) RCMD, 3 (14%) RA, 2 (10%) RARS, and 1 (4%) 5q-, RCMD-RS, CMML. The median number of prior HMA therapies was 2 (range 1-4) with a median duration of prior therapies from time of diagnosis to enrollment of 22.7 months (range 6.3-56.1). The median number of OPN-305 cycles administered is 5 (2-22) with 5 of 9 (55.5%) patients having received azacitidine add-back after 16 weeks of OPN-305 monotherapy. A total of 5 (29%) patients developed AEs related to OPN-305 all grade 1 with gastrointestinal disorders being the most frequent (23.5%). At this point, no significant drug related toxicity or unexpected infectious complications have been seen and combination with azacitidine has been well tolerated. To date three (20%) patients were taken off study due to progression to AML and 4 (27%) due to no response all at the 5 mg/kg dose. There is no evidence of treatment related anti-drug antibodies or statistically significant dynamic changes in cytokines in any of the patients. Myelodysplastic syndromes are a complex and heterogeneous group of bone marrow failure disorders characterized by ineffective hematopoiesis and poor prognosis. There is an urgent need for the development of well tolerated, novel therapies in the treatment of MDS which can delay progression, improve patient survival and quality of life and reduce the social and economic burden of transfusion dependence. Commenting on today’s announcement Mary Reilly VP Pharmaceutical Development & Operations said “OPN-305 data emerging in this heavily pre-treated group of patients is very encouraging, the unmet need for a safe and tolerable product for this patient population is significant and we are happy to be in collaboration with the MD Anderson Cancer Center one of the leading clinical center’s in this hematological area” Opsona is a leading immunology drug development company, focused on novel therapeutic approaches to key targets of the innate immune system associated with a wide range of major human diseases, including cancer, autoimmune and other inflammatory diseases. The company was founded in 2004 by three world-renowned immunologists at Trinity College, Dublin. Opsona has a strong international investor consortium including: Amgen Ventures, BB Biotech Ventures, EMBL Ventures, Enterprise Ireland, Fountain Healthcare Partners, Inventages Venture Capital, Novartis Venture Fund, Omnes Capital, Roche Venture Fund, Seroba Life Sciences, Shire and Sunstone Capital.
Mary Francies R.,Kerala Agricultural University |
Joseph J.,Kerala Agricultural University |
Zachariah G.,Kerala Agricultural University |
Leenakumary S.,Rice Research Station |
And 3 more authors.
Journal of Tropical Agriculture | Year: 2013
PTB 59 'Samyuktha' specifically bred for koottumundakan system of cultivation in Kerala, is a pureline, selected from Culture C3-2 developed through hybridization and selection, with M 210 (the dwarf mutant of traditional tall indica rice variety PTB 10) and PTB 28 as parents. Samyuktha is a photo-period insensitive, medium tillering variety of 112 - 117 days duration, growing to an average height of 123 cm with a yield potential of 3600 kg ha-1 under koottumundakan system. This short-bold red kernelled rice variety is moderately resistant to major pests of rice crop. It is non-lodging in the koottumundakan system of cultivation, with non-shattering grains and moderate dormancy. Considering its qualities, PTB 59 'Samyuktha' was released as a variety for cultivation in koottumundakan system during 2010.
Saritha R.,Reg Agril Research Station |
Dharma Reddy K.,RARS
Pestology | Year: 2013
Investigations were made to study the spatial distribution of whiteflies on Sunflower. Based on the variance-mean ratio, chi-square test and dispersion indices thrips have shown aggregated distribution and negative binomial model fitted the population pattern. Intraplant distribution studies indicated that the middle strata provided the most reliable estimate of the whitefly population on sunflower.
Saritha R.,Reg Agril Research Station |
Dharma Reddy K.,RARS
Pestology | Year: 2013
Investigations were made to study the spatial distribution of leaf hoppers on Sunflower. Based on the variance-mean ratio, chi-square test and dispersion indices thrips have shown aggregated distribution and negative binomial model fitted the population pattern. Intraplant distribution studies indicated that the middle strata provided the most reliable estimate of the leaf hopper population on sunflower.
Gouri Shankar V.,RARS |
Venkata Ramana Rao P.,APRRI and RARS |
Bindu Priya P.,RARS |
Nagesh Kumar M.V.,RARS |
And 2 more authors.
Sabrao Journal of Breeding and Genetics | Year: 2013
Maintenance of genetic purity of a hybrid is essential to exploit its full potential. Genetic purity is generally assessed by conducting grow out test (GOT) where morphological and floral characters are analyzed, however results may be influenced by the environment. Further, it is expensive and time consuming. DNA based markers are rapid, reliable and cost effective for hybrid purity assessment. Several molecular markers such as RAPD, ISSR, AFLP, SSR, EST-SSR are being used for purity determination. Co-dominant markers are preferred over dominant markers as they reveal the heterozygous condition of the hybrid accurately. SSR markers are reliable markers for purity assessment. Because of inherent limitations of SSR markers, EST-SSR markers are considered as high quality markers as they give sharp, clear, and robust amplification. In this study, the parents (DPC-9, CS-1 and CS-18) of the two castor hybrids PCH-111 (DPC-9 × CS-1) and PCH-222 (DPC-9 × CS-18) were screened using 283 EST-SSR markers, nine markers showed polymorphism between DPC-9 and CS-1 and 10 between DPC-9 and CS-18 whereas 3 expressed polymorphism among 3 parents. As castor is highly cross pollinated crop and cytoplasmic male sterility system is not yet reported, the possible impurities in hybrid seed are selfing of female parent and pollination of female parent by unknown pollen parent. Selfed seed of female parent can be identified using single polymorphic marker, however contamination of female parent with unknown male parent can be detected reliably by using more number of polymorphic markers. © Society for the Advancement of Breeding Research in Asia and Oceania (SABRAO) 2013.
Asian Textile Journal | Year: 2010
A variety with big boll hirsutum cotton coupled with high yield and desirable fiber quality parameters such as 2.5% span length, with optimum strength and micronaire value (fineness) ensures better income and premium price for quality in the market. MCU5, LRAS166, and other pure-bred varieties were cultivated in the upland cotton G hirsutum group, but these genotypes had smaller boll size of nearly 3.6 to 4.2 gram. Standard and uniform agronomic practices were adopted in the entire field to get uniform expression in all the plants. The upland cotton selection Hyps 156 has an attractive plant type with high combining ability for heterosis breeding programs. The seed Industry has been highly benefited by using this variety as male parent in heterosis breeding program and developed a large number of commercially marketed hybrids in conventional and subsequently as GMO cotton forms of the BG-I and BG-II types.
Singhal H.C.,RARS |
Tomar S.S.,RARS |
Baraiya B.R.,RARS |
Sikarwar R.S.,RARS |
Legume Research | Year: 2010
The experiment was conducted to collect the basic information on genetic divergence, genetic parameters of variability and correlation coefficient in characters under study among 88 Horsegram genotypes and was laid out in a completely randomized block design with three replications. The analysis of variance revealed highly significant differences among genotypes for all the traits. The phenotypic coefficient of variation (PCV) was higher than that of genotypic coefficient of variation (GCV) and found to be high to moderate for all traits except for days to 50% flowering. Study of genetic divergence revealed the existence of wide diversity among the genotypes studied. On the basis of the results obtained, these 88 genotypes were grouped into ten clusters. The varieties belong to clusters VIII and IX having greate statistical distance may be selected for hybridization programme as they are expected to produce good segregants.