Rangaraya Medical College RMC

andhra Pradesh, India

Rangaraya Medical College RMC

andhra Pradesh, India
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Kuna A.K.,Tamil University | Kumar K.J.,Rangaraya Medical College RMC
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

An accurate, Precise, Simple and Economical High Performance Liquid Chromatographic method for the estimation of Imatinb mesylate in its tablet dosage form has been developed. The method so developed is Reverse Phase High Performance Liquid Chromatographic method using Hypersil BDS C 18 column (Length: 250nm, Diameter: 4.6nm, Particle size: 5μ) with a simple Ammonium Phosphate buffer and acetonitrile mixed in a proportion of 40:60v/v as mobile phase. The method so developed was validated in compliance with the regulatory guidelines by using well developed Analytical method validation tool which comprises with the analytical method validation parameters like Linearity, Accuracy, Method precision, Specificity, System suitability, Robustness and Ruggedness. The results obtained were well within the acceptance criteria.

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