Dwarampudi G.S.,Rangaraya Medical College
International Journal of Pharma and Bio Sciences | Year: 2015
Neonatal hyperbilirubinemia resulting in clinical jaundice is a common problem during the first weeks of neonates life. Most common cause of hyperbilirubinemia in neonates is physiological hyperbilirubinemia. Although physiological hyperbilirubinemia is 100% curable;Fallow up and the early treatment has become difficult due to early discharge from the hospital. Physiological hyperbilirubinemia results from immature liver cell having very low uridine diphospho glucuronosyl transferase activity compared to mature hepatocyte, low concentration of Bilirubin binding ligand Albumin, and higher volume of short life erythrocytes in the circulation. Studies strongly argues for the primacy of bilirubin in the etiology of kernicterus. present study: estimation of neonatal cord blood albumin and bilirubin levels and assessing their reliability with the third day neonatal peripheral venous sample bilirubin levels. To assess the reliability of cord blood albumin and bilirubin levels in early prediction of Hyperbilirubinemia in neonates. Present study was conducted on 70 neonates (term & preterm) whose cord blood was estimated for albumin and bilirubin levels by dye binding method and modified dimethylsulfoxide methods respectively. Incidence of Hyperbilirubinemia is confirmed by estimating peripheral venous blood bilirubin levels by DMSO method on day third of the neonate . Frequency of hyperbilirubinemia in neonates in our center at term is 52 % and in pre-tem is 70% 10,11. Cord blood albumin level of < 2.8 gm/dl has a sensitivity of 74% and specificity of 88%9,13 and Cord bilirubin level >2mg/dl has 70% sensitivity and 90%specificity 7, 9, in predicting the risk of neonatal hyperbilirubinemia. Present study supports that Cord blood albumin and bilirubin levels are reliable in predicting development of hyperbilirubinemia. This study also supports gestational age has impact in developing hyperbilirubinemia. By early detection of hyperbilirubinemia treatment option will be simple phototherapy which prevent neonate from having unnecessary transfusions. Recommendations: Hence it is recommended to include estimation of cord blood albumin and bilirubin levels as a routine investigation for the neonates to prevent the dangerous consequences of neonatal hyperbilirubinemia like kernicterus. ABREVATIONs: CSA: Cord serum Albumin, TB: Total bilirubin, UB: Un conjugated bilirubin.
Reddy Kilim S.,Rangaraya Medical College |
Rao Chandala S.,Siddhartha Medical College
Journal of Clinical and Diagnostic Research | Year: 2013
Objectives: To investigate the relationship between the menopausal status and related hormonal variation of oestradiol with plasma lipid concentrations. Material and Methods: Fifty premenopausal women and fifty postmenopausal women subjects were selected. Data was collected through clinical evaluation from questionnaires and laboratory investigations. Plasma oestradiol and lipid profile determinations were done by using competitive binding im munoassay methods and enzymatic methods respectively. Student's T test and Pearson's test of correlation were used for the statistical analysis. Pvalues of < 0.05 were considered to be statistically significant. Results: There was a significant increase in serum Total Cholesterol (TC), Triglycerides (TG), LDLcholesterol and VLDL cholesterol levels in postmenopausal women. HDLcholesterol level was significantly decreased in postmenopausal women. The calculated atherogenic index (Total Cholesterol/HDL ratio) was significantly increased in postmenopausal women as compared to that in premenopausal women. Oestradiol concentration was significantly lower (p<0.001) in postmenopausal women. Discussion: Oestrogen changes the vascular permeability by increasing nitrous oxide production. It maintains a healthy lipoprotein profile. It stabilizes the endothelial cells, enhances antioxidant effect and alters fibrinolysis protein. All these cardio protective mechanisms are lost in menopause. Postmenopausal women develop an increased risk for cardiovascular disease. Conclusion: Menopause leads to changes in lipid profile by reducing HDL, and elevating Total Cholesterol (TC), triglycerides (TG), LDLcholesterol and VLDLcholesterol, thus increasing the risk for cardiovascular disease. These changes are caused by reduced oestrogen concentrations which are seen in menopause.
Vupputuri M.,Konaseema Institute of Medical science |
Vupputuri M.,GIDE Hospital |
Kandepu M.,Rangaraya Medical College |
Devireddy H.R.,Devireddy Diabetes and Hormone Center
Indian Journal of Pediatrics | Year: 2014
5α-reductase (5α-R) deficiency is an important cause of ambiguious genitalia in genetic males; however therapeutic experience in literature is limited. In this report authors describe a child with 46 XY Disorder of Sexual Differentiation (DSD), due to 5α-reductase deficiency, who was managed with Dihydrotestosterone (DHT) gel. © 2013 Dr. K C Chaudhuri Foundation.
PubMed | Konaseema Institute of Medical science and Rangaraya Medical College
Type: Journal Article | Journal: Journal of orthopaedic case reports | Year: 2017
Post traumatic hip dislocations are very rare in children. Neglected anterior hip dislocations in children are not described in literature so far. Here, we present a case of 6 weeks old anterior hip dislocation successfully managed by open reduction.A 9-year-old male child presented with neglected anterior hip dislocation on left side. Open reduction carried out through direct anterior approach to hip. Congruent reduction is achieved. At final follow up of 1 year, the child had unrestricted activities of daily living and no radiological signs of osteonecrosis or any joint space reduction.There is paucity of literature over neglected post traumatic anterior hip dislocations in children. The treatment options vary from closed reduction after heavy traction to sub trochanteric osteotomy. However, we feel that open reduction through direct anterior approach is the preferred mode of management whenever considered possible.
Nagendra Prasad B.,Rangaraya Medical college |
Bhaskar K.,Sv Medical College
Journal of South India Medicolegal Association | Year: 2016
The determination of an age in adolescents has played an important role in Medico-legal work. Identification of the age is required in the Criminal Justice delivery System like child labour, rape, kidnapping, mass disasters, marriage, prostitution and murder cases especially the skeleton remains are available for analysis. It is important in connection with the question of criminal responsibility of several different cases and awarding of judicial punishment etc. The present investigation is the estimation of age in adolescents i.e., both boys and girls through fusion of Ossification Centers of ones of elbow joints examination by Radiological Technique (X-rays) in the age group of 14-17 years in 50 boys and 50 girls in Tirupati region. © 2016 South India Medico-Legal Association. All rights reserved.
Bhaskar K.,Sv Medicalcollege |
Nagendraprasad B.,Rangaraya Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2016
“Caution is advised while decontaminating a victim of poisoning. Over enthusiasm may result in eliminating the patient, not the poison!” -John Morrision Poisoning has been known to mankind since time immemorial and the study of various poisons and their eff ects has always fascinated mankind. References to poisons and various instances of poisoning are available in Indian Shastras, Egyptian Papyri and Sumerian writings. Since then many substances considered advantages and disadvantages in the form of food or poisons have been discovered. Those substances which are used unfortunately to take away the man’s life or cause ill health have been changing. Some of the great persons who were poisoned to death are Chatrapati Shivaji Maharaj,2-3 whose bed was poisoned, Socrates, who was made to drink Hemlock (Conium maculatum) and Rasputin who was poisoned with cyanide and then shot.Aluminum phosphide poisoning, a rodenticide is also posing a formidable challenge and is on the way for taking the number one position. As poisoning trends go on changing, it is necessary to know the poisoning trends from time to time. © 2015, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.
Chavali L.V.,Rangaraya Medical College |
Vijaya Bhaskar R.,Andhra Medical College |
Bhaskar Reddy J.,Rangaraya Medical College
Indian Journal of Medical and Paediatric Oncology | Year: 2014
Umbilical cord neoplasms are rare. Teratomas, which are accepted as the only true neoplasms at this site, are exceptional. These tumors are polymorphic in their presentation and are often associated with other abnormalities, with exomphalos being the most common abnormality. Histologically these tumors show mature tissues from all the three-germ layers. Immature elements as seen in our case are rare. Germ cells which have gone astray during embryonic development are thought to be the cells of origin of these tumors.
Satya Chandrika V.,Rangaraya Medical College |
Surya Kirani K.R.L.,Rangaraya Medical College
Journal of Krishna Institute of Medical Sciences University | Year: 2016
Background: Infection is a major problem in orthopedics leading to implant failure and in severe cases, amputation and even mortality. Aim and Objectives: The aim of this study is to isolate and identify organisms from postoperative Orthopaedic implant infections and determine their antibiogram. Method and Materials: This prospective study was conducted on 50 cases of infected implants from Orthopaedics ward, Government General Hospital, Kakinda from 1st June 2014 to 1st November 2014 after obtaining clearance from Institutional Ethics Committee. Pus samples were collected using two sterile swabs. One is used for Gram's stain and the other for inoculation on MacConkey and Blood agar. Isolates were identified according to the standard protocols and antibiotic sensitivity was done by Kirby Bauer's disc diffusion technique. Results: Out of 50 samples, 45(90%) were culture positive and 5(10%) were sterile for aerobic bacteria. Staphylococcus aureus (30%) is common isolate followed by Coagulase Negative Staphylococci (CONS) (20%), Escherichia coli (16%), Klebsiella sps (10%), Pseudomonas aeruginosa (6%), Acinetobacter species (4%), Proteus species (4%). Most of Gram positive cocci are resistant to Methicillin (64%) followed by Ciprooxin (36%) and Cotrimoxazole (28%). They were mostly sensitive to Vancomycin, Linezolid, Amoxycillin Clavulanic acid and Cefotaxime. Gram negative bacilli are resistant to Cotrimoxazole (65%) followed by Ciprooxacin (60%) and Ceftriaxone (60%) and sensitive to Carbapenems (80%), Piperacillin Tazobactam (60%) and Amoxycillin Clavulanic acid (60%). Extended Spectrum Beta Lactamase (ESBL) production is seen in 60% of Gram negative bacilli. Conclusions: The incidence of multidrug resistance pathogens as a cause of implant infections is rising. Adequate preventive measures should be enforced to prevent the spread of antibiotic resistant organisms. © Journal of Krishna Institute of Medical Sciences University.
Rajyalakshmi R.,Rangaraya Medical College |
Chakrapani R.N.B.,Rangaraya Medical College
Indian Journal of Pathology and Microbiology | Year: 2016
Griscelli syndrome (GS) is a rare autosomal recessive disorder caused by mutation in the MYO5A (GS1), RAB27A (GS2), and MLPH (GS3) genes, characterized by a common feature, partial albinism. The common variant of three, GS type 2, in addition, shows primary immunodeficiency which leads to recurrent infections and hemophagocytic lymphohistiocytosis. We, herewith, describe a case of GS type 2, in a 4-year-old male child who presented with chronic and recurrent fever, lymphadenopathy, hepatosplenomegaly, and secondary neurological deterioration; highlighting the cytological and histopathological features of lymph nodes. Hair shaft examination of the child confirmed the diagnosis. © 2016 Indian Journal of Pathology and Microbiology.
Reddi B.R.,Rangaraya Medical College
Indian Journal of Surgery | Year: 2013
A clinical observation to diagnose parotid hemangioma is presented in this article. A hemangioma can be made to distend by blocking its venous outflow. If a distended hemangioma is located within the parotid gland, it stretches the parotid capsule. Thus application of pressure over parotid venous outflow causes the hemangioma to bulge, thereby stretching the parotid capsule. It makes the outline of the gland clinically apparent. This observation is useful to differentiate a hemangioma present in the parotid gland from one that is placed outside the gland like an intramuscular hemangioma of the masseter muscle or internal jugular phlebectasia. © Association of Surgeons of India 2012.