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Lynchburg, VA, United States

Randolph College is a private liberal arts and science college located in Lynchburg, Virginia, United States. Founded in 1891 as Randolph-Macon Woman's College, it was renamed on July 1, 2007, when it became coeducational.The college offers 30 majors, 44 minors, pre-professional programs in law, medicine, veterinary medicine, engineering, and teaching, and dual degree programs in engineering and nursing. Bachelor of arts, bachelor of science and bachelor of fine arts degrees are offered. Randolph offers master of arts in teaching and master of education degrees.The College, which has always been known for preparing its alumnae and alumni to succeed in a global environment with study abroad programs, recently announced Bridges Not Walls, a Quality Enhancement Program required by its regional accrediting agency . Bridges Not Walls, approved by the College's faculty during 2010, is designed to enhance students' intercultural competence.Randolph is one of only 240 colleges and universities in the United States with a Phi Beta Kappa chapter.Randolph operates a study abroad program, Randolph College Abroad: The World in Britain at the University of Reading, England.Randolph is an NCAA Division III school competing in the Old Dominion Athletic Conference . The college fields varsity teams in six men's and eight women's sports. The coed riding team competes in both the ODAC and the Intercollegiate Horse Show Association.Notable alumni include author Pearl S. Buck, who won the Nobel Prize and Pulitzer Prize, former U.S. Senator Blanche Lincoln, and CNN senior political correspondent Candy Crowley.Randolph is a member of The Annapolis Group of colleges in the United States, the Council of Independent Colleges in Virginia, and the Virginia Foundation for Independent Colleges. Wikipedia.

Kurt Y.,Randolph College
Cryptologia | Year: 2010

In this paper, I share my experience teaching a course in cryptology at Pomona College in Claremont, CA. I describe the student body, topics covered in class along with activities implemented, and ideas that flourished as a result of teaching this course. © Taylor & Francis Group, LLC.

Schenk A.K.,Randolph College | Witbrodt B.C.,University of Nebraska Medical Center | Hoarty C.A.,University of Nebraska Medical Center | Carlson Jr. R.H.,Creighton University | And 3 more authors.
Journal of the American Geriatrics Society | Year: 2011

Objective: To describe a system that uses off-the-shelf sensor and telecommunication technologies to continuously measure individual lifespace and activity levels in a novel way. Design: Proof of concept involving three field trials of 30, 30, and 21 days. Setting: Omaha, Nebraska, metropolitan and surrounding rural region. Participants: Three participants (48-year-old man, 33-year-old woman, and 27-year-old male), none with any functional limitations. Measurements: Cellular telephones were used to detect in-home position and in-community location and to measure physical activity. Within the home, cellular telephones and Bluetooth transmitters (beacons) were used to locate participants at room-level resolution. Outside the home, the same cellular telephones and global positioning system (GPS) technology were used to locate participants at a community-level resolution. Physical activity was simultaneously measured using the cellular telephone accelerometer. Results: This approach had face validity to measure activity and lifespace. More importantly, this system could measure the spatial and temporal organization of these metrics. For example, an individual's lifespace was automatically calculated across multiple time intervals. Behavioral time budgets showing how people allocate time to specific regions within the home were also automatically generated. Conclusion: Mobile monitoring shows much promise as an easily deployed system to quantify activity and lifespace, important indicators of function, in community-dwelling adults. © 2011 The American Geriatrics Society.

Cattaruzza F.,University of California at San Francisco | Johnson C.,University of California at San Francisco | Leggit A.,University of California at San Francisco | Grady E.,University of California at San Francisco | And 9 more authors.
American Journal of Physiology - Gastrointestinal and Liver Physiology | Year: 2013

Chronic pancreatitis (CP) is a devastating disease characterized by persistent and uncontrolled abdominal pain. Our lack of understanding is partially due to the lack of experimental models that mimic the human disease and also to the lack of validated behavioral measures of visceral pain. The ligand-gated cation channel transient receptor potential ankyrin 1 (TRPA1) mediates inflammation and pain in early experimental pancreatitis. It is unknown if TRPA1 causes fibrosis and sustained pancreatic pain. We induced CP by injecting the chemical agent trinitrobenzene sulfonic acid (TNBS), which causes severe acute pancreatitis, into the pancreatic duct of C57BL/6 trpa1+/+ and trpa1-/- mice. Chronic inflammatory changes and pain behaviors were assessed after 2-3 wk. TNBS injection caused marked pancreatic fibrosis with increased collagen-staining intensity, atrophy, fatty replacement, monocyte infiltration, and pancreatic stellate cell activation, and these changes were reflected by increased histological damage scores. TNBS-injected animals showed mechanical hypersensitivity during von Frey filament probing of the abdomen, decreased daily voluntary wheel-running activity, and increased immobility scores during open-field testing. Pancreatic TNBS also reduced the threshold to hindpaw withdrawal to von Frey filament probing, suggesting central sensitization. Inflammatory changes and pain indexes were significantly reduced in trpa1-/- mice. In conclusion, we have characterized in mice a model of CP that resembles the human condition, with marked histological changes and behavioral measures of pain. We have demonstrated, using novel and objective pain measurements, that TRPA1 mediates inflammation and visceral hypersensitivity in CP and could be a therapeutic target for the treatment of sustained inflammatory abdominal pain. © 2013 the American Physiological Society.

Keane J.,Lynchburg College | Gilstrap T.,Randolph College
Environmental Earth Sciences | Year: 2012

In the present work, geological and geophysical methods were used to delineate the locations of multiple mafic intrusions at the Claytor Nature Study Center (CNSC) near Bedford, VA. An investigation of the groundwater hydrology of CNSC was launched in 2007. As a first step in that project a preliminary geological survey revealed sparse evidence of a number of diabase intrusions in the area. While diabase intrusions are not particularly permeable features, contact metamorphism of the host rock could provide conduits for groundwater due to stress fractures and joints and high-temperature recrystallization of the rock matrix. Following the geological survey, geophysical surveys including seismic refraction, ground penetrating radar, and magnetic ground measurements were conducted to determine the location and extent of these multiple igneous intrusions. Seismic and radar surveys proved to be inconclusive, but the magnetic surveys showed strong magnetic anomalies. The magnetic data were obtained using a Geometrics G-856 proton precession magnetometer and were interpreted using the Mag2dc algorithm and SGeMS geostatistical software. The results show that the intrusions are dikes that cut across nearly perpendicular to the regional metamorphic structures and trend generally north-south with a dip of approximately 75°-90° to the west. These findings are consistent with one of the general directions of stresses associated with the North Atlantic seafloor spreading in late Triassic or early Jurassic period. Subsequent hydrologic testing and groundwater modeling confirm the role of the dikes in the overall hydrogeology of the site. © 2011 Springer-Verlag.

Jayant K.,Cornell University | Auluck K.,Cornell University | Rodriguez S.,Randolph College | Cao Y.,Cornell University | Kan E.C.,Cornell University
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | Year: 2014

We report on factors that affect DNA hybridization detection using ion-sensitive field-effect transistors (ISFETs). Signal generation at the interface between the transistor and immobilized biomolecules is widely ascribed to unscreened molecular charges causing a shift in surface potential and hence the transistor output current. Traditionally, the interaction between DNA and the dielectric or metal sensing interface is modeled by treating the molecular layer as a sheet charge and the ionic profile with a Poisson-Boltzmann distribution. The surface potential under this scenario is described by the Graham equation. This approximation, however, often fails to explain large hybridization signals on the order of tens of mV. More realistic descriptions of the DNA-transistor interface which include factors such as ion permeation, exclusion, and packing constraints have been proposed with little or no corroboration against experimental findings. In this study, we examine such physical models by their assumptions, range of validity, and limitations. We compare simulations against experiments performed on electrolyte-oxide- semiconductor capacitors and foundry-ready floating-gate ISFETs. We find that with weakly charged interfaces (i.e., low intrinsic interface charge), pertinent to the surfaces used in this study, the best agreement between theory and experiment exists when ions are completely excluded from the DNA layer. The influence of various factors such as bulk pH, background salinity, chemical reactivity of surface groups, target molecule concentration, and surface coatings on signal generation is studied. Furthermore, in order to overcome Debye screening limited detection, we suggest two signal enhancement strategies. We first describe frequency domain biosensing, highlighting the ability to sort short DNA strands based on molecular length, and then describe DNA biosensing in multielectrolytes comprising trace amounts of higher-valency salt in a background of monovalent saline. Our study provides guidelines for optimized interface design, signal enhancement, and the interpretation of FET-based biosensor signals. © 2014 American Physical Society.

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