Mamidwar S.,S N Institute Of Pharmacy |
Hodge S.,Ranbaxy Research Laboratory Ltd |
Deshmukh V.,S N Institute Of Pharmacy |
Borkar V.,S N Institute Of Pharmacy
International Journal of Pharmaceutical Sciences Review and Research | Year: 2012
Hot-melt extrusion (HME) is one of the most widely applied processing technologies in the plastic, rubber and food industry. Interest in the pharmaceutical applications is growing rapidly and is evident from the increasing number of patents and publications. Limitations related to bioavailability and site specific drug delivery can be overcome by this technique. This technology has gained focus because of its ease of operation and fast processing. Melt extrusion is considered to be an efficient technology with particular advantages over solvent processes like co-precipitation for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, suppositories, implants, stents, transdermal systems and ophthalmic inserts. The types of extruders currently available for hot melt extrusion are single and twin-screw extruders. Depending on the geometric design and function, the screw is generally composed of three different zones: feeding zone, melting zone, and the metering zone. HME also includes of its advantages, applications of hot melt extrusion technology and the optimization of HME process through which product quality and performance is assured.