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Āmta, India

Das A.,Ramsaday College | Das A.,Shibpur Dinobundhoo Institution College | Roy S.,Shibpur Dinobundhoo Institution College | Mondal P.,Vivekananda Mahavidyalaya | And 8 more authors.
RSC Advances | Year: 2016

Structural and spectroscopic studies on 2-amino-3-hydroxy-anthraquinone (AQ), an analogue of anthracycline drugs, were carried out using computational methods. The interactions of AQ with anionic surfactant sodium dodecyl sulphate (SDS) and cationic surfactant cetyltrimethylammonium bromide (CTAB) were investigated in aqueous solution at physiological pH (7.4) by UV-Vis spectroscopy, and compared with the well-known anthracycline drugs. The affinity of such molecule to surfactant micelles may mean it can act as a model system for a biological membrane-drug interaction, which is important in determining the biological action of this molecule. The binding constant, partition coefficient and Gibbs free energy for the binding and distribution of AQ between the bulk aqueous solution and surfactant micelles were determined for AQ-surfactant interactions. It was observed that hydrophobic interaction plays a crucial role in the binding of AQ to SDS micelles, while the hydrophilic interaction plays an important role in its interaction with CTAB micelles. These interactions also have a vital role in the distribution of AQ between surfactant micelle-water phases. This study gives an idea that the present molecule may successfully permeate biological membranes, so AQ was allowed to interact with human breast adinocarcinoma cell MDA-MB-231. Experimental findings established that AQ induces apoptosis by means of nucleation into these cells. © The Royal Society of Chemistry 2016. Source


Mondal A.,Ramsaday College | Das A.,Ramsaday College | Adhikary B.,Bengal Engineering and Science University | Mukherjee D.K.,Ramsaday College
Journal of Nanoparticle Research | Year: 2014

The search for more efficient catalytic systems that might combine the advantages of both homogenous (catalyst modulation) and heterogenous catalysis (catalyst recycling) is still the challenge of modern chemistry. With the advent of nanochemistry, it has been possible to prepare soluble analogues of heterogenous catalysts. These nanoparticles are generally stabilized against aggregation into larger less active particles by electrostatic or steric protection. In the present case, we demonstrate the use of room temperature ionic liquids (ILs) as effective agents of dispersion of palladium nanoparticles (prepared from palladium chloride with 5 ± 0.5 nm size distribution) that are recyclable catalysts for aerobic oxidation of alcohols under mild conditions. The particles suspended in ILs show no metal agglomeration or loss of catalytic activity even on prolonged use. An attempt has been made to elucidate the reaction mechanism of aerobic alcohol oxidation using a soluble palladium catalyst. © Springer International Publishing Switzerland 2014. Source


Mondal A.,Ramsaday College | Adhikary B.,Indian Institute of Science | Mukherjee D.,Ramsaday College
Colloids and Surfaces A: Physicochemical and Engineering Aspects | Year: 2015

An easy, green and economically viable approach has been made to synthesize highly active and ordered structures of cobalt nanoparticles. The air stable nanoparticles were prepared from cobalt sulphate using tetra butyl ammonium bromide as surfactant and sodium borohydride as reductant. The cobalt nanocolloids in aqueous medium were found to be efficient as catalysts for the degradation of toxic organic dyes. Our present study involves degradation of methyl orange using cobalt nanoparticles and easy recovery of the catalyst from the system. The recovered nanoparticles could be recycled several times without loss of catalytic activity. Palladium nanoparticles prepared from palladium chloride and the same surfactant was found to degrade the organic dye effectively but lose their catalytic activity after recovery. Based on chemical and kinetic studies an attempt has been made to elucidate the mechanism of dye degradation using the nanoparticles. © 2015 Elsevier B.V. Source


Kim D.H.,Kyung Hee University | Im J.K.,Kyung Hee University | Kim D.W.,Kyung Hee University | Cheong M.,Kyung Hee University | And 2 more authors.
Journal of Chemical Sciences | Year: 2011

Asymmetric alkyl substitution of various benzophenone Schiff base substrates under biphasic conditions proceeded using optically active Palladium(II) complexes. The corresponding products were obtained in high yields but with moderate enantiomeric excess (ee) . Addition of specific ionic liquids to the reaction medium enhanced reactivity and selectivity for phase transfer catalytic (PTC) glycine alkylation. It has been found that there is an anionic influence of the ionic liquids that modify the steric environment around the enolate ion. A computer-assisted molecular design of enantioselective phase-transfer catalysis with the palladium complex and the ionic liquid has been done. © Indian Academy of Sciences. Source

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