University Ramon y Cajal Hospital

Madrid, Spain

University Ramon y Cajal Hospital

Madrid, Spain

Time filter

Source Type

Truchuelo M.T.,University Ramon y Cajal Hospital | Jimenez N.,University Ramon y Cajal Hospital | Mavura D.,Regional Dermatology Training Center | Jaen P.,University Ramon y Cajal Hospital
Actas Dermo-Sifiliograficas | Year: 2015

Introduction The high rate of relapse of acne lesions following oral isotretinoin treatment is a common problem which remains unsolved. To avoid or minimize relapses, topical retinoids have been used for many years as maintenance treatment. However, adverse effects frequently occur. Aims To determine the efficacy and safety of a new retinoid combination (Retinsphere technology) in maintaining post-treatment response to oral isotretinoin. Patients and methods Prospective, randomized, double-blind and vehicle-controlled study of 30 patients with acne previously treated with isotretinoin. Treatment with the retinoid combination was applied to one side of the face and vehicle was applied to the other, once daily, for 3 months. Standardized photographs were taken using RBX technology at baseline, 1.5 months and 3 months. The primary efficacy endpoint was the appearance of relapse on the treated side compared to the vehicle-treated side. Other endpoints included lesion count, investigator-reported improvement, patient-reported improvement, impact on quality-of-life, and side effects. Results Although the majority of patients did not reach the total target dose of oral isotretinoin, the relapse rate was significantly lower on the retinoid-treated side compared to the vehicle-treated side. Likewise, improved lesion count and excellent tolerance were observed. Conclusions This new retinoid combination (Retinsphere technology) were effective and safe as maintenance therapy after post-treatment response to oral isotretinoin in patients with acne. © 2014 Elsevier España, S.L.U. and AEDV.


PubMed | University Ramon y Cajal Hospital and Regional Dermatology Training Center Kilimanjaro Christion Medical Center
Type: Journal Article | Journal: Actas dermo-sifiliograficas | Year: 2015

The high rate of relapse of acne lesions following oral isotretinoin treatment is a common problem which remains unsolved. To avoid or minimize relapses, topical retinoids have been used for many years as maintenance treatment. However, adverse effects frequently occur.To determine the efficacy and safety of a new retinoid combination (Retinsphere technology) in maintaining post-treatment response to oral isotretinoin.Prospective, randomized, double-blind and vehicle-controlled study of 30 patients with acne previously treated with isotretinoin. Treatment with the retinoid combination was applied to one side of the face and vehicle was applied to the other, once daily, for 3 months. Standardized photographs were taken using RBX technology at baseline, 1.5 months and 3 months. The primary efficacy endpoint was the appearance of relapse on the treated side compared to the vehicle-treated side. Other endpoints included lesion count, investigator-reported improvement, patient-reported improvement, impact on quality-of-life, and side effects.Although the majority of patients did not reach the total target dose of oral isotretinoin, the relapse rate was significantly lower on the retinoid-treated side compared to the vehicle-treated side. Likewise, improved lesion count and excellent tolerance were observed.This new retinoid combination (Retinsphere technology) were effective and safe as maintenance therapy after post-treatment response to oral isotretinoin in patients with acne.


Truchuelo M.T.,University Ramon y Cajal Hospital | Vano-Galvan S.,University Ramon y Cajal Hospital | Alcantara J.,University Ramon y Cajal Hospital | Perez B.,University Ramon y Cajal Hospital | Jaen P.,University Ramon y Cajal Hospital
Pediatric Dermatology | Year: 2012

Lipschütz ulcer (LU) is an uncommon condition that usually affects prepubertal and pubertal girls. It can be misdiagnosed as a sexually transmitted disease or even as a sign of child abuse, causing great anxiety to patients and their families. We present two cases of LU consecutively affecting twin sisters. To our knowledge, this is the first case in two family members, supporting infectious transmission. We propose airborne transmission as the most probable cause in our cases. © 2012 Wiley Periodicals, Inc.


PubMed | University Ramon y Cajal Hospital
Type: Case Reports | Journal: Pediatric dermatology | Year: 2012

Lipschtz ulcer (LU) is an uncommon condition that usually affects prepubertal and pubertal girls. It can be misdiagnosed as a sexually transmitted disease or even as a sign of child abuse, causing great anxiety to patients and their families. We present two cases of LU consecutively affecting twin sisters. To our knowledge, this is the first case in two family members, supporting infectious transmission. We propose airborne transmission as the most probable cause in our cases.

Loading University Ramon y Cajal Hospital collaborators
Loading University Ramon y Cajal Hospital collaborators