Rameesh Institute of Vocational and Technical Education

Greater Noida, India

Rameesh Institute of Vocational and Technical Education

Greater Noida, India
SEARCH FILTERS
Time filter
Source Type

Jaju S.B.,Sant Gadge Baba Amravati University | Indurwade N.H.,Sant Gadge Baba Amravati University | Sakarkar D.M.,Sant Gadge Baba Amravati University | Fuloria N.K.,Rameesh Institute of Vocational and Technical Education | And 2 more authors.
Pharmacognosy Research | Year: 2010

Background: The purpose of present investigation to isolate -sitosterol diglucosyl caprate from the rhizomes of Alpinia galanga. Methods: The methanolic extract of the rhizomes of plant Alpinia galanga was subjected to column chromatography and was eluted with ethyl acetate-methanol (99:1) to yield compound (AG5) -sitosterol diglucosyl caprate. Various spectral techniques such as Ultraviolet (UV), Infrared (IR), Hydrogen Nuclear Magnetic Resonance (1HNMR), Carbon Nuclear Magnetic Resonance (13CNMR), and MASS spectrometry (MS), were employed to determine and elucidate. Results: Chemical and spectral investigation of extract furnished a new steroidal glycoside. Conclusion: The isolated compound -sitosterol diglucosyl caprate could serve as a lead compound in synthesis of steroids.


Lokwani P.,Jaipur National University | Gupta S.,Jaipur National University | Singh N.,Rameesh Institute of Vocational and Technical Education
Journal of Chemical and Pharmaceutical Research | Year: 2011

A series of analogue and derivatives of heterocyclic bearing nitrogen, oxygen and oxazole moieties constitutes the core structure of a several biological active compounds. Oxazole containing heterocyclic compounds plays an important role in medicinal chemistry and exhibit wide range of biological activities. Benzoxazole Nucleus have been reported various types of biological activities such as Antidepressant, Antibacterial, Antifungal, Antiinflammatory, Analgesic and Anticancer.


Jain J.,RamEesh Institute of Vocational and Technical Education | Kumar Y.,ITS Paramedical College Pharmacy | Sinha R.,RamEesh Institute of Vocational and Technical Education | Kumar R.,RamEesh Institute of Vocational and Technical Education | Stables J.,U.S. National Institutes of Health
Medicinal Chemistry | Year: 2011

A series of ten compounds (Compounds J1-J10) of (±) 3-menthone aryl acid hydrazone was synthesized and characterized by thin layer chromatography and spectral analysis. Synthesized compounds were evaluated for anticonvulsant activity after intraperitoneal (i.p) administration to mice by maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure method and minimal clonic seizure test. Minimal motor impairment was also determined for these compounds. Results obtained showed that four compounds out of ten afforded significant protection in the minimal clonic seizure screen at 6 Hz. Compound J6, 4-Chloro-N-(2-isopropyl-5- methylcyclohexylidene) benzohydrazide was found to be the most active compound with MES ED50 of 16.1 mg/kg and protective index (pI) of greater than 20, indicating that (±) 3-menthone aryl acid hydrazone possesses better and safer anticonvulsant properties than other reported menthone derivatives viz. menthone Schiff bases, menthone semicarbazides and thiosemicarbazides. © 2011 Bentham Science Publishers Ltd.


Yadav R.,Rameesh Institute of Vocational and Technical Education | Tiwari R.,Rameesh Institute of Vocational and Technical Education | Chowdhary P.,Rameesh Institute of Vocational and Technical Education | Pradhan C.K.,Rameesh Institute of Vocational and Technical Education
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Trigonella foenum-graecum (Family- Fabaeace) plant is eaten in India since long. It is also known as Methi and used in Ayurvedic medicines for the treatment of wounds, abscesses, arthritis, bronchitis, and digestive disorders. In present investigation an attempt has been made for the standardization and Phytochemical evaluation of fenugreek seeds. The standardization evaluation comprises of detailed macroscopy, powder microscopy, and fluorescence analysis, physic-chemical constants such as ash value, extractive values, successive solvent extraction, moisture contents, foaming index and swelling index. The seeds extracts were also subjected to preliminary Phytochemical screening. The data obtained in present study will serve as valuable tool for identification, authentication and detection of adulterants, standardization and quality control of the drug.


Bhardwaja A.,Rameesh Institute of Vocational and Technical Education | Kumar R.,Rameesh Institute of Vocational and Technical Education | Dabas V.,Rameesh Institute of Vocational and Technical Education | Alam N.,Rameesh Institute of Vocational and Technical Education
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

Objectives: The objectives of the study were to describe the pattern and monitoring the medication compliance of anti-tubercular used in patients and to assess the knowledge among patients regarding their medications. Methods: During the 7 months prospective study, a suitably designed patient data collection form was prepared in consultation with the physician and clinical pharmacist, also referring standard textbooks and journals, which include information of patient demographics details such as age, gender, education, duration of disease, and medications history. Results were analyzed by using Wilcoxon signed-ranks test. Key findings: Among the 39 patients who completed the 2 months follow up study, there was statistically significant increase in medication adherence score from baseline. Baseline with first follow up revealed a mean increase in medication adherence level of 1.718 ± 0.759 and (p < 0.0001) which is statistically significant. Baseline to second follow up show a mean increase of 2.435 ± 0.852 and (p < 0.0001) which is statistically significant. The major reasons to stop medication were as follows: 23(58.97%) patients said that they stopped/miss the medication because of forgetfulness, 12(30.77%) patients stopped/miss medication because high cost of medications, 20(51.28%) patients stop/miss medication because Lack of access to hospital/drug store. Conclusions: The finding of this study may suggest that a well-structured tuberculosis patient counseling by pharmacist result in better medication adherence which may indirectly result in better clinical outcome.


Alam N.,Jamia Hamdard University | Bhardwaj A.,Rameesh Institute of Vocational and Technical Education | Tiwari R.,Rameesh Institute of Vocational and Technical Education | Sharma S.,Rameesh Institute of Vocational and Technical Education | Dabas V.,Rameesh Institute of Vocational and Technical Education
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

Objective: To evaluate the drug utilization of the Non-Steroidal anti-inflammatory drugs in South Delhi Hospital. Method: The study was a simple randomised prospective survey study. This prospective study was carried out for a period of six months in selected areas of South Delhi region. Key findings; Randomly selected 300 subjects were selected. During the six month study period, total of 300 patients were enrolled as per the inclusion and exclusion criteria. Among the 300 study patients 157 (52.3%) were male and 143 (47.6%) were females. it was observed that maximum number 83 (27.6%) were in the age range of 31-40 years followed by 68 (22.6%) patients in the range of 41 - 50 years. During the study it was observed that Aryl acetic acid derivatives (Aceclofenac, Diclofenac) were the most frequently prescribed drugs category (52.5%) followed by Paracetamol (26.6 %), Ibuprofen (10.5%), Nimesulide (6.26%), Lornoxicam (4%). Among the individual drugs aceclofenac was the most commonly prescribed drug (32%), followed by Paracetamol (26%), Ibuprofen (10.5%), and Nimesulide (6.26%) & combination therapy were preferred therapy. 143 (47.6%) of total patients showed a good adherence with the prescribed treatment. Adherence was found to be slightly better in females (24.3%) than in male (23.3%). Conclusions: NSAIDs users were more prevalent in middle age groups (40yrs) patients and in male. Aryl acetic acid (Diclofenac & Aceclofenac) was the most frequently prescribed drug followed by Paracetamol, Ibuprofen and Nimesulide, Lornoxicam. Combination therapy was the preferred mode of therapy, few of the patients showed poor compliance, Average number of drugs per prescription was found to be 1.65%.


Sinha R.,RamEesh Institute of Vocational and Technical Education | Sara U.V.S.,JKK Nataraja Dental College and Hospital | Khosa R.L.,Bharat Institute of Technology | Stables J.,U.S. National Institutes of Health | Jain J.,RamEesh Institute of Vocational and Technical Education
Medicinal Chemistry Research | Year: 2011

A series of aryl acid hydrazones of substituted aromatic acid hydrazides (D 1 to D 20) were synthesised and evaluated for anticonvulsant activity. Aryl acid hydrazones of Nicotinic acid hydrazide (D 8, D 9, and D 10) have displayed excellent protection in maximal electroshock screen. These compounds have also exhibited excellent binding properties with Lys 329 residue of gamma amino butyrate amino transferase (GABA-AT) in Lamarckian genetic algorithm based flexible docking studies. Compound D 8, N 1-(4-chlorobenzylidene) nicotinohydrazide was found to be the most potent analog with ED50 value of 16.1 mg/kg and protective index (PI = TD 50/ED 50) value of > 20, which was much greater than that of the prototype drug phenytoin (PI = 6.9). It has shown free binding energy value of -10.20 kcal/mol and inhibition constant (Ki) value of 33.30 nM for GABA-AT, indicating that aryl acid hydrazones of nicotinic acid hydrazide could be considered as a new pharmacophore in the design of novel anticonvulsant drugs. © Springer Science+Business Media, LLC 2010.


Sinha R.,RamEesh Institute of Vocational and Technical Education | Sara U.V.S.,Raj Kumar Goel Institute of Technology | Khosa R.L.,Bharat Institute of Technology | Stables J.,U.S. National Institutes of Health | Jain J.,RamEesh Institute of Vocational and Technical Education
Central Nervous System Agents in Medicinal Chemistry | Year: 2013

A series of twelve compounds (Compounds RNH1-RNH12) of acid hydrazones of pyridine-3-carbohydrazide or nicotinic acid hydrazide was synthesized and evaluated for anticonvulsant activity by MES, scPTZ, minimal clonic seizure and corneal kindling seizure test. Neurotoxicity was also determined for these compounds by rotarod test. Results showed that halogen substitution at meta and para position of phenyl ring exhibited better protection than ortho substitution. Compounds RNH4 and RNH12, were found to be the active analogs displaying 6Hz ED50 of 75.4 and 14.77 mg/kg while the corresponding MES ED50 values were 113.4 and 29.3 mg/kg respectively. In addition, compound RNH12 also showed scPTZ ED50 of 54.2 mg/kg. In the series, compound RNH12 with trifluoromethoxy substituted phenyl ring was the most potent analog exhibiting protection in all four animal models of epilepsy. Molecular docking study has also shown significant binding interactions of these two compounds with 1OHV, 2A1H and 1PBQ receptors. Thus, N-[(meta or para halogen substituted) benzylidene] pyridine-3-carbohydrazides could be used as lead compounds in anticonvulsant drug design and discovery. © 2013 Bentham Science Publishers.


PubMed | RamEesh Institute of Vocational and Technical Education
Type: Comparative Study | Journal: Central nervous system agents in medicinal chemistry | Year: 2013

A series of twelve compounds (Compounds RNH1-RNH12) of acid hydrazones of pyridine-3-carbohydrazide or nicotinic acid hydrazide was synthesized and evaluated for anticonvulsant activity by MES, scPTZ, minimal clonic seizure and corneal kindling seizure test. Neurotoxicity was also determined for these compounds by rotarod test. Results showed that halogen substitution at meta and para position of phenyl ring exhibited better protection than ortho substitution. Compounds RNH4 and RNH12, were found to be the active analogs displaying 6Hz ED50 of 75.4 and 14.77 mg/kg while the corresponding MES ED50 values were 113.4 and 29.3 mg/kg respectively. In addition, compound RNH12 also showed scPTZ ED50 of 54.2 mg/kg. In the series, compound RNH12 with trifluoromethoxy substituted phenyl ring was the most potent analog exhibiting protection in all four animal models of epilepsy. Molecular docking study has also shown significant binding interactions of these two compounds with 1OHV, 2A1H and 1PBQ receptors. Thus, N-[(meta or para halogen substituted) benzylidene] pyridine-3-carbohydrazides could be used as lead compounds in anticonvulsant drug design and discovery.


PubMed | RamEesh Institute of Vocational and Technical Education
Type: Journal Article | Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) | Year: 2011

A series of ten compounds (Compounds J(1)-J(10)) of () 3-menthone aryl acid hydrazone was synthesized and characterized by thin layer chromatography and spectral analysis. Synthesized compounds were evaluated for anticonvulsant activity after intraperitoneal (i.p) administration to mice by maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure method and minimal clonic seizure test. Minimal motor impairment was also determined for these compounds. Results obtained showed that four compounds out of ten afforded significant protection in the minimal clonic seizure screen at 6 Hz. Compound J(6), 4-Chloro-N-(2-isopropyl-5-methylcyclohexylidene) benzohydrazide was found to be the most active compound with MES ED(50) of 16.1 mg/kg and protective index (pI) of greater than 20, indicating that () 3-menthone aryl acid hydrazone possesses better and safer anticonvulsant properties than other reported menthone derivatives viz. menthone Schiff bases, menthone semicarbazides and thiosemicarbazides.

Loading Rameesh Institute of Vocational and Technical Education collaborators
Loading Rameesh Institute of Vocational and Technical Education collaborators