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Kumar T.A.,University | Rajbala S.,University | Himanshu S.,Meerut Institute of Engineering and Technology | Antariksh K.,Rameesh Institute of Voc and Technology Education
Der Pharma Chemica

Present study shows the synthesis of 7 however, an alternative route was used in this work, in which a commercially available intermediate, 5 (1,4,7,10-tetraazacyclododecane-1,4,7-tris(tbutyl) acetate: DO3A-t-Bu-ester) was used as starting material instead of cyclam and a higher overall yield (77%) was achieved. A convergent approach was chosen to synthesize the hybrid ligand, in which the derivatives of a bisphosphonate and Cyclam metal chelator (7) were synthesized. The carboxylate acid substituted bisphosphonate, 3-bis-(dibenzyloxyphosphoryl) propanoic acid (3), was synthesized by a literature procedure with an overall yield of 27%. Blood kinetics findings in rabbits are an indication of the excellent in vivo stability of the 99mTc-AI and non-osseous tissue uptake of 99mTc-AI is minimal and when assessed with its rapid blood clearance accounts for the low soft tissue activity. Rapid incorporation of phosphonates into calcified tissue leads to their short presence in the circulation. By Receptor binding studies of Scatchard plot analysis revealed affinity of the AI on tumor cell lines (Soas-2) and Scintigraphy observed that the uptake of the conjugate was faster than that of the ALN and MDP alone. Source

Katara A.,Rameesh Institute of Voc and Technology Education | Pradhan C.K.,Rameesh Institute of Voc and Technology Education | Singh P.,Teerthanker Mahaveer University | Singh V.,Rameesh Institute of Voc and Technology Education | Ali M.,Jamia Hamdard University
Journal of Essential Oil-Bearing Plants

Aromatic compounds in the steam distilled volatile oil obtained from aerial parts of Shrubby basil (Hindi - Ramtulasi), Ocimum gratissimum Linn. (Lamiaceae) were identified by gas chromatography (GC) and gas chromatography/mass spectrometry (GC-MS). The volatile oil mainly comprises of twenty (20) components, out of which all twenty constituents comprising 100 % of the oil were identified. The volatile oil mainly contains 13 monoterpenes (68.10 %) and bornyl acetate (14.5 %) was found to be predominant constituents followed by β-pinene (10.8 %), camphor (9.0 %), c-tagetone (8.6 %), t-tagetone (7.4 %), αpinene (4.2 %), myrtenal (4.1 %), α-thujene (3.0 %), α-camphene (1.8 %), O-methyl eugenol (1.6 %), ctagetone isomer (1.4 %), sabinene (0.9 %) and α-terpineol (0.8 %). Five sesquiterpene comprising (20.2 %) i.e. α-Selinene (5.9 %), t-caryophyllene (5.5 %), β-guaiene (4.0 %), β-gurjunene (2.0 %) and bicyclo germacrene (2.8 %). The two non terpenic components comprise (11.7 %) i.e. ethyl cyclohexenal ketone (7.1 %), n-butyl benzoate (4.6 %). The antimicrobial activity of O. gratissimum oil was studied by cup plate method against both Gram-positive and negative bacterial strains and pathogenic fungal species. Antimicrobial activity was concentration dependent on Shigella flexineri, Bacillus cereus and Candida albicans. © 2013 Copyright Har Krishan Bhalla & Sons. Source

Yadav R.,Rameesh Institute of Voc and Technology Education | Kaushik R.,Rameesh Institute of Voc and Technology Education
International Journal of Pharmacy and Technology

According to the Ayurveda plants are have so many constituent which may be used for the treatment of so many diseases. Herbal drugs are easily available and have fewer side effects. So many of the people are attracted towards the herbal plant drugs. Fenugreek is easily available in our kitchen and use as a drugs from oldest time. Fenugreek was used to ease childbirth and to increase milk flow. Today, it is still taken by Egyptian women for menstrual pain and as hilba tea to ease stomach problems of tourists. They contain mucilage, sugars, an alkaloid- trigonellin, which is not poisonous- cholin and a scented compound. Medicinal Action and Uses of Fenugreek like Allergies, Appetite/loss of Catarrh/bronchial, Cholesterol/high, Diabetic Retinopathy, Gas, Gastric Disorders, Lung Infections, Mucus Excessive, Throat/sore, Abscesses, Anemia, Asthma, Boils, Body Odour, Bronchitis, cancer, Eyes/swollen, Fevers, Gallbladder Problems, Heartburn, Inflammation, Sinus Problems, Ulcers, Uterine Problems, Water Retention focused the investigator's attention on this plant. Source

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