Hospital Ramazzini

Carpi, Italy

Hospital Ramazzini

Carpi, Italy
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Mengoli M.C.,University Hospital Policlinico of Modena | Longo L.,Hospital Ramazzini | Varini S.,University Hospital Policlinico of Modena | Rossi G.,Regional Hospital Parini | Lococo F.,Unit of Thoracic Surgery
Annals of Thoracic Surgery | Year: 2017

Thymomas are rare epithelial mediastinal tumors showing a certain propensity for local and intrathoracic recurrences. Otherwise, extrathoracic metastases are very rarely reported and are usually associated with type B thymomas or thymic carcinomas. We present a challenging patient with an invasive (Masaoka-Koga stage IIb) medullary type A thymoma with recurrent extrathoracic metastases (pulmonary and vertebral localizations occurring 2 and 7 years after the initial radical thymectomy, respectively). Despite type A thymoma being considered a low-grade malignancy with a scarce propensity to recurrence, the present case should alert clinicians to the possibility of bone metastasis. Long-term follow-up in this slow-growing neoplasm is then mandatory. © 2017 The Society of Thoracic Surgeons


PubMed | Regional Hospital Parini, Hospital Ramazzini and University of Modena and Reggio Emilia
Type: | Journal: Lung cancer (Amsterdam, Netherlands) | Year: 2016

The occurrence of secondary EGFR mutation T790M in exon 20 and histologic transformation are common mechanisms underlying resistance to EGFR first- or second-generation tyrosine kinase inhibitors (TKI). We describe here on a hitherto unreported mechanism of EGFR TKI resistance synchronously combining squamous-cell carcinoma change and occurrence of the EGFR exon 20 S768I secondary mutation in a 43 year-old woman with stage IV adenocarcinoma harbouring EGFR exon 21 L858R mutation. After 8 months of response to gefitinib, the patient experienced EGFR TKI resistance and died of leptomeningeal neoplastic dissemination.

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