Ram Eesh Institute of Vocational and Technical Education 3

Greater Noida, India

Ram Eesh Institute of Vocational and Technical Education 3

Greater Noida, India
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Alam M.N.,Ram Eesh Institute of Vocational and Technical Education 3 | Bhardwaj A.,Ram Eesh Institute of Vocational and Technical Education 3 | Hoda M.Q.,Ram Eesh Institute of Vocational and Technical Education 3 | Gupta C.,Ram Eesh Institute of Vocational and Technical Education 3
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015

Objectives: Comparative study to check the efficacy of pH Strip & pH Gloves for Detection of Bacterial Vaginosis in a Tertiary Care Hospital. Methods: It was a duly approved, cross-sectional study in which 50 subjects were enrolled from Tertiary care hospital, New Delhi, India. Written informed consent was obtained from all women. Vaginal swabs were collected for vaginal pH measurement. Vaginal pH was evaluated immediately with the pH strips and vaginal pH glove simultaneously. Results: The study was done on to check the efficacy of pH strip & pH gloves in pregnant as well as non-pregnant women by regularly visiting the tertiary care hospital. Among 50 subjects 8(16%) were Pregnant and 42(84%) were Non-pregnant. The mean age of the patients included in the study was found to be 26.1±19.5 years. After a Gram stain and microscopic examination of samples obtained from 50 women, those with intermediate flora and Candida infection were excluded and the final analysis was done on 40 samples. Among 40, 15 were diagnosed with BV and 25 had normal vaginal flora based on Nugents’ score. Conclusions: Our findings show that vaginal pH determination is relatively sensitive, but less specific in detecting women with BV. Both pH glove and pH strip are equally suitable for screening women with BV on an outpatient basis. Further studies are required to explore the possibility of self-evaluation of vaginal pH with pH glove at community level. © 2015, International Journal of Pharmacy and Pharmaceutical Science. All right resurved.


Aggarwal B.,HR Institute of Pharmacy | Singla R.K.,Netaji Subhas Institute of Technology | Ali M.,Hamdard University | Singh V.,Ram Eesh Institute of Vocational and Technical Education 3 | And 3 more authors.
Medicinal Chemistry Research | Year: 2015

Phytochemical studies of ethanolic extract of stems of Ichnocarpus frutescens resulted in the isolation of tetracyclic triterpenic ester lanosteryl oleate (6), two new monoterpenic esters, menth-1(7)-en-9-olyl dodecanoate (7), and 2-(4-methylcyclohex-3-enyl)propyl dodecanoate (8). Their structures were established on the basis of extensive spectral data analysis and chemical methods. From the literature survey, it was revealed that none of these three compounds have been reported earlier from any other parts of I. fructescens. Using StarDrop, drug metabolism and pharmacokinetic parameters have been studied, while data of toxicological endpoints were generated using Derek Nexus. 7 is metabolically stable as compared to 6 and 8. All three molecules are highly lipophilic so tendency to get distributed in brain and adipose tissue is more. Based on the current knowledge database, Derek Nexus predicted that these molecules are not mutagenic, carcinogenic, genotoxic, hepatotoxic, hERG channel inhibitor, nephrotoxic, neurotoxic but StarDrop found them as probable developmental toxic. So in a word, these phytoconstituents have drug-likeness potential and can be evaluated for possible targets. © 2014 Springer Science+Business Media New York.

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