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Saplontai-Pop A.,University of Medicine and Pharmacy, Cluj-Napoca | Mot A.,Babes - Bolyai University | Moldovan M.,Raluca Ripan Institute of Chemistry | Oprean R.,University of Medicine and Pharmacy, Cluj-Napoca | And 5 more authors.
Open Life Sciences | Year: 2015

Background: The extracts of Allium cepa are known for their medical use: antioxidant, antiinflammatory, antimicrobial, fibrinolytic and antiplatelet properties. Our study aims to establish, using in vitro tests, the antiplatelet and antioxidant character, the link between them and the extract acidity, from seven varieties of A. cepa. Methodology: The qualitative and quantitative presence of polyphenols and anthocyanins in the extracts was determined using UV-Vis and HPLC. Quantitative determination of the thiosulfinates compounds was calculated using their reaction with 4-mercaptopyridine. Antioxidant character was determined using 3 methods (FC, DPPH and TEAC), and antiplatelet effect was measured by in vitro tests on platelet rich plasma obtained from human blood. Principal Findings/Results: The white variety of A. cepa has the most alkaline pH, the largest amount of thiosulfinate compounds and the most powerful antiplatelet effect, but a very small amount of flavonoids and an antioxidant effect almost nonexistent, in contrast with red variety of A. cepa which is the opposite. Conclusions/Significance: The white variety of A. cepa had very high anitiplatelet activity suggesting the potential use of A. cepa extract in treating cardiovascular diseases. © 2015 Aniela Saplonţai-Pop et al. licensee De Gruyter Open. Source


Saplontai-Pop A.,University of Medicine and Pharmacy, Cluj-Napoca | Moldovan M.,Raluca Ripan Institute of Chemistry | Oprean R.,University of Medicine and Pharmacy, Cluj-Napoca | Orasan O.,University of Medicine and Pharmacy, Cluj-Napoca | And 2 more authors.
Studia Universitatis Babes-Bolyai Chemia | Year: 2014

The present study aims to establish a correlation between the estimated thiosulfinate compound content of Allium cepa L. (A. cepa) juices and their antiplatelet activity. The juices were obtained from three different varieties of A. cepa, cultivated in three different regions of Romania.The thiosulfinate compound content was estimated using a spectrophotometric method, based on the reaction with 4-mercapto-pyridine (a chromogenic thiol, with a maximum absorbance coefficient at 324 nm). The constant of the reaction kinetic curve was obtained by overlapping experimental data with an exponential function of first degree.The antiplatelet activity of the mentioned juices was measured by using in vitro tests with platelet rich plasma (PRP) obtained from blood collected from healthy human people, with arachidonic acid as platelet agonist.A statistically significant direct proportionality between the estimated thiosulfinate compound content and the antiplatelet activity of the tested A.cepa juices was established. © 2014, Universitatea Babes-Bolyai, Catedra de Filosofie Sistematica. All rights reserved. Source


Popescu V.,Technical University of Cluj Napoca | Molea A.,Technical University of Cluj Napoca | Dinescu A.,National Institute for Research and Development in Microtechnologies | Rusu-Trisca C.,National Institute for Research and Development in Microtechnologies | And 2 more authors.
Chalcogenide Letters | Year: 2015

Optical properties of PbS crystals obtained by Chemical bath deposition (CBD) and ultrasonic chemical bath deposition (US-CBD) on glass substrates have been studied. Ultrasounds determined an increase of reflectance, refraction index, real and imaginary parts of dielectric constant, a decrease of absorption coefficient and a red shift of the maxims of absorption coefficient, extinction coefficient and imaginary part of dielectric constant. The bad gaps of the obtained crystals are higher than the values corresponding to bulk PbS both for sample obtained in static and ultrasonic bath. Ultrasounds determined the decreasing of direct band gaps and the increasing of Urbach energy. The changes of optical properties of the sample obtained in sonochemical conditions can be correlated with the increase of the crystallite and grain size. © 2015, National Institute R and D of Materials Physics. All rights reserved. Source


Saplontai-Pop A.,University of Medicine and Pharmacy, Cluj-Napoca | Moldovan M.,Raluca Ripan Institute of Chemistry | Ionescu C.,University of Medicine and Pharmacy, Cluj-Napoca | Suciu-Petrescu M.,University of Medicine and Pharmacy, Cluj-Napoca | And 2 more authors.
Key Engineering Materials | Year: 2016

Particular importance is given to natural therapy since ancient times, the main advantages are immediate availability, high tolerability for the body and reduced incidence of adverse reactions, compared to synthetic pharmaceuticals drugs. Allium cepa L. extracts has gained a special attention in recent times, some of their compounds showing promising antioxidant activity, anti-diabetic, anti-inflammatory, anticancer, antimicrobial, antihyperlipidemic, fibrinolytic, antiplatelet effects, immunomodulators, anti-ischemic effect. This review is to compile the valuable pharmacological effect of thiosulfinates compounds from Allium cepa L. extracts. In the last 100 years have been published over 1,200 scientific papers that describes in detail the potential medical effects of the Allium extracts, thanks to the over 200 components identified, including vitamins, sulfur compounds, flavonoids, aminoacids, proteins, lipids and elements such as selenium and various antioxidants [1,2,3]. In the composition of Allium cepa L., water is found in a proportion of 80-95%, the remaining 5-20% being the dry matter. From this, 65% is in the form of non-structural carbohydrate. In some varieties, most of the dry matter is stored like a carbohydrate (sugars) as fructan, a polymer based on fructose. In others varieties, the dry substance has small amounts of fructan and large amounts of glucose, fructose and sucrose. In dry matter, are found other categories of important chemical compounds with beneficial effects on human health: flavonoids and organosulphur compounds [4]. It is known that the antiplatelet agents are among the most used drugs by the specialist cardiologist, there are numerous studies showing a similar effect exercised by some extracts obtained from different varieties of plants belonging to the family Alliaceae (A. cepa L., A. sativum L., A. ampeloprasum L.); those containing organosulphur compounds with platelet aggregation inhibition effect. © 2016 Trans Tech Publications. Source


Mesaros A.S.,UMF Iuliu Hatieganu | Furtos G.,Raluca Ripan Institute of Chemistry | Mesaros M.F.,UMF Iuliu Hatieganu | Badea M.E.,UMF Iuliu Hatieganu
Applied Mechanics and Materials | Year: 2014

Shear Bond Strength testing is one of the most common used tests for Orthodontics Adhesives. However, the standardizations of such procedures is quite difficult due to a large number of factors. While scientists are designing their studies in order to reduce errors, sometime they may find themselves in front of technical difficulties. A custom device was developed in order to allow a testing procedure that is closer to in vitro conditions. The device, mounted on a material testing machine permits sample inclination to a degree that reduces tensile component to the shear stress, therefore more accurate readings of the values are available and standardization of shear bond testing procedures is more probable. © (2014) Trans Tech Publications, Switzerland. Source

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