Rajsekhar P.B.,Rajkeerth Aromatic and Biotech Pvt Ltd |
Arvind Bharani R.S.,Rajkeerth Aromatic and Biotech Pvt Ltd |
Jini Angel K.,Rajkeerth Aromatic and Biotech Pvt Ltd |
Ramachandran M.,Rajkeerth Aromatic and Biotech Pvt Ltd |
Rajsekhar S.P.V.,Rajkeerth Aromatic and Biotech Pvt Ltd
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015
Nanotechnology is one of the most interesting areas of research in modern science. In medicine, nanotechnology-based drug delivery system is an advanced method for treating number of dreadful diseases. In the recent years, plant-derived medicines play an important role in health care. The nanoparticles prepared from biological sources do not produce any harmful side effects. Curcumin (1, 7-Bis-(4-hydroxy-3-methoxyphenyl)-hepta-1, 6-diene-3, 5-dione) is a bio-active component isolated from the rhizome of Curcuma longa Linn, which exhibits various pharmacological activities. But the pharmaceutical application of curcumin was limited due to its poor water solubility and bioavailability. However, the clinical studies proved that curcumin nanoparticles exhibit increased solubility and bioavailability. The therapeutic efficacy of curcumin nanoparticles increases by applying the drug in different nanoforms. In this review, the therapeutic applications of curcumin nanoparticles against cancer, microbial infection, acquired immunodeficiency syndrome, malaria, Alzheimer's and inflammatory diseases were discussed.