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Sharma A.,VNS Institute of Pharmacy | Gupta S.P.,Rajiv Gandhi Institute of Pharmacy | Upmanyu N.,P.A. College | Jain S.,VNS Institute of Pharmacy | Garg G.,VNS Institute of Pharmacy
Der Pharma Chemica | Year: 2011

Several 3-substituted 1,2-benzisoxazole derivatives were synthesized from treatment of 4-amino- 2-hydroxy acetophenone by different aldehyde substitution with the hope that different substituent formed at the third position show significant antimicrobial activity. 4-amino-2-hydroxy acetophenone 1 on treatment with different aldehydes 2a-e in sodium hydroxide afford 3a-e. Compounds 3a-e on oximation yields 4a-e. Compounds 4a-e on treatment with silica gel and sodium carbonate affords 5a-e. The resultant 3-substituted 1,2-benzisoxazole derivatives have been characterized by spectral data. The compounds 5a-e have been screened for their antimicrobial activity. Compounds 5a, 5b and 5e exhibit good antimicrobial activity. Source


Majumder P.,Rajiv Gandhi Institute of Pharmacy
International Journal of Phytomedicine | Year: 2012

Zyziphus oenoplia is a perennial shrub used in traditional medicine for treating hyper acidity, Ascaris infection, stomachalgia and healing of wounds. The objective of this study was to investigate the root extracts of this plant, to evaluate their wound healing potential in rats. Excision, Incision and Dead space wound modals were used to evaluate the wound healing activity of the extracts on wister rats. In each modal, animals were divided into six groups of six animals. Each model, group I & II served as control and reference standard. In wound models, group III, IV, V and VI animals were treated with plant root extracts (300 and 400mg/kg/day) for 18 days and 10days respectively. The vehicles effect on the rate of wound healing were assessed by the wound closure rate, epithelialisation period, tensile strength, granulation tissue weight, hydroxyproline content and histopathology of granulation tissue. The ethanol extract of plant root promoted wound healing activity significantly in all the wound modals. High rate wound contraction (P<0.001), decrease in the epithelialisation period (14.67±0.33), high skin breaking strength (501.53±2.18g), significant increase in granulation tissue weight (P<0.001) and hydroxyproline (P<0.001) content were observed in ethanol root extract. Histological studies of the granulation tissues of the ethanolic extract treated group showed the lesser number of inflammatory cells, and increase collagen formation than the control and also compared with other groups. Phytoconstituents like flavanoids, alkaloids, steroids, triterpenoids, saponins etc were also confirmed by phytochemical test. The data obtained in this investigation indicated that the ethanolic root extract possesses better wound healing activity and it can treat different types of wounds in human being too. Source


Arunkumark V.,Karpagam University | Paridhavi M.,Rajiv Gandhi Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2013

Essential oils constitute a relatively common group of natural products present in aromatic medicinal plants. They are volatile liquids usually with pleasant and sometimes intensive odors (aroma).Essential oils are well known for its activity in lungs related diseases. They maintained the ventilation and drainage of the sinuses, had an antiinflammatory effect on the trachea5 and reduced asthma. The essential oil isolated from Zanthoxylumlimonellawere proved a large number of compounds. Many compounds were detected and proved by previous workers, some of them yet to be identified and screened.Traditional usage of the plant indicates various uses even some are contradictory.In the present study showed that the oil is moderately active against grampositive and significantly no action against gram-negative. Source


Thirumalai D.,Vellore Institute of Technology | Paridhavi M.,Rajiv Gandhi Institute of Pharmacy | Gowtham M.,Rajiv Gandhi Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Nature always stands as a golden mark to exemplify the outstanding phenomena of symbiosis. Premna Herbacea belonging to genus Premna and family Verbenaceae was one among them. Morphological and microscopical characters of the plant were studied. Preliminary photochemical analysis of ethanol, chloroform, petroleum ether and aqueous extracts of these plants were done. The results showed strong presence of triterpenoids and alkaloids with trace amounts of carbohydrates and flavonoids. The physiochemical parameters of the plant were within the limits. Root powder was treated with different reagents and observed for fluorescence under visible light and under UV light of short and long wavelength. They exhibited fluorescence.TLC and HPTLC of various extracts of the plant also yielded satisfactory results. Further evaluation needs to be carried out on Premna Herbacea in order to investigate the obscured areas and their practical clinical applications, which can be used for the welfare of the mankind. Source


Abraham P.,Rajiv Gandhi Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2013

Exfoliation involves the removal of the oldest dead skin cells on the skins outermost surface to help maintain healthy skin. The most serious form of skin cancer is caused by excessive exposure to the sun (ultraviolet radiation). Skin cells that are damaged are at greater risk of becoming abnormal and cancerous. Herbal skin exfoliates enriched with flavanoids penetrate deep into the skin, nourishes it, and prevents photo damage such as discolouration and hyper pigmentation. Since herbal exfoliate shows a good antimicrobial and antioxidant activity, it shields the skin from environmental toxins, pollution and micro organism. Herbal exfoliation may also prevent skin cancer. Advantages of facial peel which Improves the texture of the skin, makes the skin healthy, makes the skin look more radiant, reduces appearance of wrinkles and fine lines, removes the dirt clogged in the pores, prevents acne and aging of the skin. Disadvantages mainly High price of some of the products and methods used to achieve it, exfoliation will lead to some initial redness to the skin, At the end of chemical peels, the skin will frost, with colors varying from a bright white to grey on the skin surface, plastic beads or polymer often used as exfoliates are not biodegradable where they remain in the soil or river for a very long time polluting the environment. Considering the above disadvantages, effort had been taken to formulate an herbal facial peel which is cheap, ecofriendly and effective on human skin without causing irritation. Cyphomandra&phaseolus genus belonging to the family Solanaceae whichare used for this studies. Source

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