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The objective of the manuscript is to evaluate the effectiveness of NACKED EYE SINGLE TUBE RED CELL OSMOTIC FRAGILITY TEST (NESTROFT) as screening tool for detection of B-THALASSEMIA TRAIT against the HPLC method. NESTROFT and HPLC METHOD were applied to blood sample of 84 patients of suspected cases of B-Thalassemia and other haemoglobinopathies. Out of 84, Beta Thal Trait 13 cases (15.4%), Delta Beta Thal Trait 9(10.7%), Thal Major 5(5.9%), HPFH 7(8.3), Sickle Homo 12 (14.2 %), Sickle Trait 10(11.9%) Sickle Thal Trait 7(8.3%) & IDA 21(25%) cases were detected by HPLC. The NESTROFT test was successful in detecting 12/13 subjects with B-Thalassemia trait. Sensitivity of the test was 92.31 % and specificity was 63.38 %. The test was positive in detecting other haemoglobinopathies like sickle cell disease also. The test proved to be simple, cheap easy to perform and adaptable for mass screening coming close to an ideal screening test for B-Thalassemia trait.


Prasad C.,Rajendra Institute of Medical science RIMS | Singh S.B.,Rajendra Institute of Medical science RIMS | Mahato T.,Rajendra Institute of Medical science RIMS | Praksh S.,Rajendra Institute of Medical science RIMS | Chandra S.,Rajendra Institute of Medical science RIMS
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Various hemoglobinopathies are one of the major public health problems in Ranchi, a district located in the northeast part of INDIA. An accurate diagnosis of hemoglobinopathies is very important for management and prevention. To estimate the occurrence of Sickle Cell Anemia and Thalassemia in suspected cases of genetic disorders by using HPLC retention time chromatogram. Blood sample of suspected cases of genetic disorders were assessed in the department of Laboratory Medicine, RIMS, Ranchi for work up of anemia or other blood related disorders. This blood samples were assessed on BIORAD variant II. Results: A total of 107 blood samples in years 2013 f were examined by HPLC retention time chromatogram. Out of these 63(58.88%) cases showed abnormal hemoglobin fractions. The major abnormality observed was of high HbA2. A cutoffvalue of >3.9% was considered for diagnosis of beta thalassemia trait (BTT). A total of 13 cases (12.1%) of BTT was diagnosed. Other hemoglobinopathies were as follows: Sickle homo 12 (11.2%), Sickle trait 10 (9.3%), dB Thal trait 9 (8.4%), Sickle Thal 7 (6.5%), Heredetery Persistent Fetal Hemoglobin (HPFH) 7 (6.5%), B Thal Major 5 (4.6%). This study revealed that genetic load of Sickle Cell Anemia and Thalassemia is 58.88% in study sample.


Prasad C.,Rajendra Institute of Medical science RIMS | Rai H.N.,Rajendra Institute of Medical science RIMS | Singh S.B.,Rajendra Institute of Medical science RIMS
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Sickle cell anemia (SCA) is a genetic disorder characterized by severe hemolytic anemia and shorter life span. Diagnosis is an important aspect in the management of this disease. To assess the efficacy of Super Speed Sickle Solubility test in the diagnosis of SCA in population attending this medical institute. A total of 63 patients were screened in 2013. All the positive samples were assayed by solubility test simultaneously analysed on high-performance liquid chromatography (HPLC) 'BIO-RAD' Variant II analyzer for the confirmation along with the distinction of SCA (heterozygous) and sickle cell disease (homozygous). Out of all 63 patients screened, 29 were found to be positive with HPLC as well as with solubility test too. A total of 10 samples was diagnosed as SCA (heterozygous), 12 samples were diagnosed as sickle cell homozygous and 7 cases as Sickle Thal with HPLC and Solubility tests. In case of Sickle cell Homozygous, Solubility test was found to be fairly effective with 75.0 % and 80.85% sensitivity and specificity respectively, with the predictive value of positive test 57.14% and a predictive value of negative test 90.47 % along with an Accuracy of 79.37 %. It was observed that in case of Sickle Cell Trait, the sensitivity specificity, positive predictive and negative predictive values were 76.92 %, 97.5 %, 57.14% and 92.8% respectively. We found that Solubility test in Sickle Thal Trait revealed sensitivity of 70.0 %, specificity 73.58 %, positive predictive value 33.33 %, negative predictive value 92.85 % along with an Accuracy of 73.0 %. This study concludes that solubility test is better for mass screening and does not need any microscope. It is also cost effective test for early detection of disease and for timely intervention to minimize morbidity and mortility.


Rungta R.,Rabindranath Tagore International Institute of Cardiac science RTIICS | Jha R.K.,Rajendra Institute of Medical science RIMS
Journal, Indian Academy of Clinical Medicine | Year: 2016

Situs inversus with levocardia aka situs inversus incomplitus, an uncommon congenital positional anomaly can be a diagnostic problem at times. We present a case of situs inversus incomplitus that was picked-up during routine investigations of a young male with a cardiac murmur. © 2016, Indian Academy of Clinical Medicine. All rights reserved.


Haider S.,Rajendra Memorial Research Institute of Medical Sciences | Kumari S.,Rajendra Institute of Medical science RIMS
Indian Journal of Community Health | Year: 2015

Background: Hospitals are the centre of cure and also the important centres of infectious waste generation. Effective management of Biomedical Waste (BMW) is not only a legal necessity but also a social responsibility. Aims and Objectives: To assess the knowledge and practice in managing the biomedical wastes among nursing staff and student nurses in RIMS, Ranchi. Materials and methods: The study was conducted at RIMS, Ranchi from Oct 2013 to March 2014 (6 months). It was a descriptive, hospital based, cross-sectional study. A total of 240 nurses participated in the present study, randomly chosen from various departments A pre-designed, pre-tested, structured proforma was used for data collection after getting their informed consent. Self-made scoring system was used to categorize the participants as having good, average and poor scores. Data was tabulated and analyzed using percentages and chi-square test. Results: The knowledge regarding general information about BMW management was assessed(with scores 0-8),it was found that level of knowledge was better in student nurses than staff nurses as student nurses scored good(6-8correct answers) in more than half of the questions (65%).Whereas staff nurses scored good in only 33.33% questions. When the practical information regarding the BMW management is assessed (with scores 0-8), it was found that staff nurses had relatively better practice regarding BMW management than students as they scored good(6-8correct answers) in 40% and 30% respectively. Conclusion: Though overall knowledge of study participants was good but still they need good quality training to improve their current knowledge about BMW. © 2015, Indian Association of Preventive and Social Medicine. All rights reserved.


Kumar V.,Rajendra Institute of Medical science RIMS | Sunderam S.,Rajendra Institute of Medical science RIMS | Haider S.,Rajendra Institute of Medical science RIMS | Kashyap V.,Rajendra Institute of Medical science RIMS
Indian Journal of Community Health | Year: 2015

Background: Anaemia in pregnant women has been regarded as very dangerous as it causes many maternal, fetal and neonatal complications. Fetal growth and pregnancy outcome largely depend upon the status of anaemia in pregnant women. Anaemia affects pregnant women all over the world-52% in developing countries compared with 23% in the developed world. The difference in prevalence of anaemia in different parts of India including Jharkhand can be attributed to the different factors. A knowledge of these factors associated with anemia will help to formulate multipronged strategies to curtail this important public health problem in pregnancy. Aims & Objectives: (1) To know the socio-demographic profile of pregnant women attending Urban Health and Training Centre (UHTC), RIMS, Ranchi. (2) To know the status of anaemia among those pregnant women and its association with different factors. Material & Methods: A descriptive cross-sectional study done at ANC clinic of UHTC, RIMS, Ranchi to determine the status of anaemia in pregnant women and various socio-demographic factors associated with it. Hemoglobin level of 149 pregnant women selected by consecutive sampling was estimated by Cyanmethemoglobin method. Statistical Analysis: Template generated in MS excel sheet and analysis was done on SPSS software. Result: Out of total 149 pregnant women anaemia was found to be present in 99 (66.4%) women. A statistically significant association of anaemia (p<.05) was found with parity and birth interval from last birth. But the association of anaemia with ethnicity, education and other factors like gestational age (trimester) was not found to be statistically significant (p>.05). Conclusion: Occurrence of anaemia was much higher in this area as compared to national average. It indicates that the anaemia continues to be a major public health problem. Efforts should be geared towards the early detection and treatment of anaemia before delivery. © 2015, Indian Association of Preventive and Social Medicine. All rights reserved.


Kumar C.,Rajendra Institute of Medical science RIMS | Haider S.,Rajendra Institute of Medical science RIMS | Kashyap V.,Rajendra Institute of Medical science RIMS
Indian Journal of Community Health | Year: 2015

Background: Hypertension is a major public health problem affecting people across the globe. Rapid change in life style and dietary practices are important factors for increasing prevalence of hypertension. High salt consumption, fat intake and low consumption of dietary fibres are important modifiable risk factors of hypertension. Aims & Objectives: 1) To determine the prevalence of hypertension in community under study. 2) To describe the association of dietary practices and hypertension in community. Materials and Methods: A descriptive cross sectional study in one of the rural field practice area (Ormanjhi) of RIMS, Ranchi was done. Sample size was determined using nMaster 2.0 software. Total 500 people were included in the study. Cluster sampling method was adopted to draw the sample. Subjects 20 years and above from both sex were eligible for the study. Pre-tested semi structured questionnaire were used for data collection. Template was generated in MS excel and data analysis was done using SPSS 13 software. Results: Prevalence of hypertension in the present study was found to be 19.8%. Mean systolic and diastolic blood pressure was found to be 122.83 mm of Hg (SD – 15.83) and 79.24 mm of Hg (SD - 8.73) respectively. Prevalence of hypertension was higher among male (22.8%) than female (16.5%) although this difference was statistically not significant (p – value = 0.075). Prevalence of hypertension was more among non-vegetarians (23.9%) compared to vegetarians (8.3%). Added salt intake was found to be significantly associated with hypertension (p - value = 0.023). Conclusions: Prevalence of hypertension was more among male population. Higher prevalence of hypertension was found among subjects with non-vegetarian diet and high salt in their diet. © 2015, Indian Association of Preventive and Social Medicine. All rights reserved.


Singh S.B.,Rajendra Institute of Medical science RIMS | Chakraborty S.,Birla Institute of Technology | Jha K.M.,Indira Gandhi Institute of Medical science | Chandra S.,Rajendra Institute of Medical science RIMS | Prakash S.,Rajendra Institute of Medical science RIMS
Music & Medicine | Year: 2013

The objective of this article is to study the impact of Hindustani ragas on the cognitive functions of the right and left cerebral hemispheres, especially of the parieto-occipital lobe, in patients with cerebrovascular accident and diffuse head injury. A randomized control trial was conducted. The case group consisted of 30 patients who received both medicine and ragas, while the control group of 30 patients received only medicine. A total of 10 Hindustani ragas were taken up, and 4 follow-ups with baseline were conducted. Nahor-Benson test, a subtest of the Post Graduate Institute–Battery for Brain Dysfunction, was used at different time intervals. Univariate repeated measures analysis revealed significant differences between the 2 groups at different time intervals, confirming that listening to ragas improved visual perceptual acuity, spatial orientation, and the cognitive functions involving both right and left hemispheres of the case group patients. © 2013, SAGE Publications. All rights reserved.


Singh S.B.,Rajendra Institute of Medical science RIMS | Chakraborty S.,Birla Institute of Technology | Jha K.M.,Indira Gandhi Institute of Medical science | Haider S.,Rajendra Institute of Medical science RIMS | Chandra S.,Rajendra Institute of Medical science RIMS
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

The paper focuses on Randomized Control Trail that was conducted to assess the impact of north Indian ragas in rehabilitation phase of the CVA and diffuse head injury patients at Rajendra Institute of Medical Sciences (RIMS) hospital, Ranchi. A total of 60 patients were investigated. Case group of 30 patients received both medicine and ragas while control group of 30 patients received medicine only. Ten ragas were taken up and four follow ups with baseline were conducted. Mini Mental State Examination (MMSE) scale was used to assess the status of cognitive function of the sixty patients in different time intervals. Univariate Repeated Measures Analysis revealed that the MMSE score to be statistically significant between the two groups, implying that listening to ragas did improve the cognitive impairment of these patients and also reduced their recovery time.


Prasad C.,Rajendra Institute of Medical science RIMS | Singh S.B.,Rajendra Institute of Medical science RIMS | Chandra S.,Rajendra Institute of Medical science RIMS | Prakash S.,Rajendra Institute of Medical science RIMS | Prakash A.,Rajendra Institute of Medical science RIMS
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

The distribution patterns of different types of leukemia in catchment area of Rajendra Institute of Medical Sciences, Ranchi was studied. This cross-sectional observational study was done for the screening of leukemia both clinically and hematologically and carried out during the period of 2009-2010.Patients was interviewed. Thorough physical examination was done Blood tests namely haemoglobin estimation, total and differential leukocyte count, platelets count, reticulocyte count and peripheral blood smear examination stained with Lieshman & Giemsa was done. Requisition for Bone marrow examination was suggested in few selected cases. Peripheral blood smear (PBS) was done with special precaution and supportive technique. A total of 46 cases of suspected leukaemia cases were selected. Chronic Myeloid Leukemia showed the highest incidence (34.7 %), followed by Acute Lymphocytic Leukemia (15.2%), Acute Myeloid Leukemia (10.8%) and Chronic Lymphocytic Leukemia (8.6 %). 13cases (28.26%) suspected were turned showed Leukemoid reaction. PBS can be used as a screening tool for earlier diagnosis of Leukemia.

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