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Shivaprasad B.M.,Hospital and Research Institute | Shivaprasad B.M.,Rajarajeshwari Dental College and Hospital | Pradeep A.R.,Hospital and Research Institute
Disease Markers | Year: 2013

Recently discovered interleukin 29 (IL-29) has antiviral properties and its production is induced by herpes viruses. This study was aimed at analyzing the effect of non-surgical periodontal treatment on IL-29 levels in gingival crevicular fluid (GCF) of chronic and aggressive periodontitis patients. A total of 60 participants were divided into healthy group (group 1; n=20), chronic periodontitis group (group 2; n=20), and aggressive periodontitis group (group 3; n=20). GCF samples collected from each subject at baseline and 6-8 weeks after scaling and root planing were quantified for IL-29 levels using ELISA. The mean IL-29 concentration in GCF was found to be highest in group 3 (92.37 pg/μl). The mean IL-29 level in group 1 and group 2 was 36.88 pg/μl and 69.35 pg/μl respectively. After scaling and root planing, the mean concentration of IL-29 in GCF was increased to 85.99 pg/μl in group 2 and to 114.64 pg/μl in group 3. Results of the present study indicate that antiviral IL-29 level was highest in GCF of aggressive periodontitis patients and least in subjects with healthy periodontium, while that of chronic periodontitis lying in between. After non-surgical periodontal therapy, IL-29 levels increased both in chronic and aggressive periodontitis patients and deserve further investigation as a potential therapeutic agent in treating periodontitis. © 2013 IOS Press and the authors. All rights reserved. Source

Kamat M.S.,Bharati Vidyapeeth Deemed University | Puranik R.S.,PMNM Dental College and Hospital | Hallur N.H.,Al Badar Dental College and Hospital | Kumar V.V.,Rajarajeshwari Dental College and Hospital | Kamat S.B.,Bharati Vidyapeeth Deemed University
Journal of Clinical and Diagnostic Research | Year: 2016

Oral Submucous Fibrosis (OSMF) is a chronic debilitating, potentially malignant disorder of the oral cavity. It is characterized by restricted mouth opening which results due to abnormal accumulation of collagen in the sub-epithelial layers leading to dense fibrous bands in the mouth. The pathogenesis of the disease is believed to be multifactorial. However, literature reports suggest a strong association of OSMF and arecanut chewing habit. The present paper presents a case of OSMF in a 12-year-old boy without arecanut chewing habit, but with a heavy practice of chewing tamarind seeds. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved. Source

Badrashetty D.,Al Jabal Al Gharbi University | Rangaswamy S.,Rajarajeshwari Dental College and Hospital | Belgode N.,Karnataka Lingayat Education Society Dental College and Hospital
Journal of Oral and Maxillofacial Pathology | Year: 2013

The calcifying epithelial odontogenic tumor (CEOT) is a rare benign tumor of the jaws. Pindborg's tumor having clear cells is extremely rare. Twelve central lesions have been reported of which only three cases have occurred in maxilla. Clear cell variant is a distinct entity, has more aggressive biological behavior and higher chances of recurrence. Hence it is important that presence of clear cells be included in histopathological diagnosis. Here we present a rare case of clear cell CEOT having aggressive behavior. Source

Supradeep Kumar K.,College of St. Joseph | Hanumantha Rao C.,Vishnu Dental College | Baburam Reddy K.V.,Vishnu Dental College | Chidambaram S.,Rajah Muthiah Dental College and Hospital | And 2 more authors.
Journal of Contemporary Dental Practice | Year: 2013

Objective: To determine the clinical applicability of Ormocer based flowable adhesive (Admira flow) in comparison with BisGMA based adhesive (Transbond XT) and Ormocer based packable adhesive (Admira). Materials and methods: Sixty human premolars, divided into group I (n = 20) Transbond XT, group II (n = 20) Admira and group III (n = 20) Admira flow were bonded with metal brackets using adhesives. Brackets were debonded in shear on an Instron universal testing machine with a crosshead speed of 1 mm per minute. The mode of bond failure was determined by modified ARI index. Results: The results obtained from SBS evaluation and modified ARI showed highest shear bond strength for Transbond XT (SD 11.64) 3.68 followed by Admira flow (SD 11.0) 2.87 and least for Admira (SD 9.42) 2.21. However, the difference was not statistically significant, but an intergroup comparison done using Independent student 't' test, showed statically significant difference between Transbond XT and Admira. Kaplan-Meier survival analysis showed least survival median value for Admira, but the survival median value is not statistically significant among the three groups. All groups had modified ARI score of three (60-70%), suggestive of cohesive type of failure. Conclusion: The in vitro study showed that flowable Ormocer can be an good alternative to commonly used BisGMA based adhesive but the its efficacy needs clinical assessment through a survival analysis. Clinical significance: Admire flow can definitely be considered as an alternative bonding system due to their comparable bond strength and debonding characters and reported properties of biocompatibility. Source

Anuroopa P.,Rajarajeshwari Dental College and Hospital | Kothiwale S.V.,KLE University | Kishan Panicker G.,Hospital and Research Center | Kripal K.,Rajarajeshwari Dental College and Hospital
Biomedicine (India) | Year: 2013

Introduction: Furcation involvement is one of the important clinical features of chronic periodontitis. It represents a challenging scenario for periodontal therapy. Class II furcation involvement warrants the use of regenerative technique. Aim: The purpose of this study was to clinically and radiographically compare the efficacy of combination of allograft material with combination of xenograft material in the treatment of mandibular Class II furcation defects. Materials and Methods: A total of 20 sites with Class II furcation defects were treated, with Demineralized Freeze Dried Bone Allograft (DFDBA) + Amniotic Membrane (AM) and Bio Oss + Collagen Membrane (CM). Plaque index (PI), gingival index (GI), pocket depth reduction (PDR), relative attachment level (RAL) and linear radiographic measurements using RVG were recorded at baseline, 6 and 12 months postoperatively. Results: At 12 months after therapy, PDR of 5.1 mm ± 0.59 & 4.75 mm ± 0.09 and RAL gain of 5.5 mm + 0.50 & 5.44 mm ± 0.09 was observed with both DFDBA+AM group & Bio Oss + CM group respectively. Bone fill of 2.08 mm ± 0.68 & percentage gain of 82.6% for the DFDBA + AM group and; 2.28 mm ± 0.49 & 87.3% respectively for Bio Oss + CM was observed. Conclusions: Within the limits of the present study, it can be concluded that at 12 months, both therapies resulted in significant PDR and RAL gains, and significant improvement was seen in bone fill with both the materials, however, there was no significant difference between both. Source

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