Babu K.,Rajah Serfoji Government Arts College |
Pitchai P.,Rajah Serfoji Government Arts College |
Sathiyaseelan M.,Rajah Serfoji Government Arts College |
Nepolraj A.,Rajah Serfoji Government Arts College
Der Pharma Chemica | Year: 2015
Some new pyrazoline derivatives were synthesized by using following synthetic sequences (i) Preparation of (E)-1- (4-aminophenyl)-3-(furan-2yl) prop-2-en-1-one (3a-b) by the reaction between p-NH2-aminoacetophenone (1) and heterocyclic aldehydes(2a-b) (ii) Preparation of (E)-1-(4-((E-)-4-chlorobenzylideneamino) phenyl)-3-(furan-2-yl) prop-2-en-1-one and (E)-1-(4-((E-)-4-chlorobenzylideneamino) phenyl)-3-(thiophene-2-yl) prop-2-en-1-one(5a-b) by the reaction of 3a-bwith p-Cl-benzaldehyde (4). (iii) Preparation of new pyrazoline derivatives 7a-hwas by the cyclysationreaction between 5a-b with semicarbazide, thiosemicarbazide, phenylhydrazine and benzhydrazide(6a-d) in alcohol medium.The structures of the synthesizedcompounds were confirmed by using UV, IR,1H-NMR, and 13CNMR spectral data. The invitro antimicrobial activity of synthesized compounds were evaluated against selective bacteria and fungus and preliminary results showed that most of the compounds showed moderate to good activity.