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Chidambaram, India

Jaikumar R.A.,Rajah Mutiah Dental College | Karthigeyan S.,Rajah Mutiah Dental College | Ali S.A.,Rajah Mutiah Dental College | Naidu N.M.,Indira Gandhi Institute of Dental science | And 2 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2015

Aim: The aim of this study was to evaluate whether the flexural strength of a commercially available, heat polymerized acrylic denture base material could be improved using reinforcements. Materials and Methods: A total of 30 specimens (65 mm × 10 mm × 3 mm) were fabricated; the specimens were divided into three groups with 10 specimens each. They were Group 1 - conventional denture base resins, Group 2 - high impact denture base resins, and Group 3 - glass reinforced denture base resins. The specimens were loaded until failure on a three-point bending test machine. An one-way analysis of variance was used to determine statistical differences among the flexural strength of three groups. Data were analyzed by SPSS software version 21.0 © (IBM Corporation, Armonk, NY, USA) and the results were obtained. Results: The flexural strength values showed statistically significant differences among experimental groups (P < 0.005). Conclusion: Within the limitations of the study polymethyl methacrylate (PMMA) reinforced with glass fibers showed the highest flexural strength values this was followed by PMMA reinforced with butadiene styrene, and the least strength was observed in the conventional denture base resins. © 2015 Journal of Pharmacy And Bioallied Sciences | Published by Wolters Kluwer - Medknow. Source


Madhulika N.,Indira Gandhi Institute of Dental science | Rangdhol R.V.,Indira Gandhi Institute of Dental science | Sitra G.,Indira Gandhi Institute of Dental science | Ballaiah J.,Indira Gandhi Institute of Dental science | And 2 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2015

Aim: This study aims to quantify the extent of DNA damage in lymphocytes of patients with oral lichen planus (OLP) and oral lichenoid reactions (OLRs) using comet assay. Methodology: Lymphocytes from peripheral blood were subjected to alkaline comet assay. Comet length (CL), head diameter (HD), percentage of DNA in head, tail length (TL), percentage of DNA in tail, tail intensity, tail mean and tail moment were compared between study group (OLP and OLR) and control group using Student's t-test. Pearson's correlation coefficient was used to examine the linear association between the variables. Results: Significantly higher levels of DNA damage was present in study group as reflected by CL, HD and TL, tail intensity and tail moment with P = 0.0001; percentage of DNA in head and tail with P = 0.02 and tail mean with P = 0.012. Conclusion: This study brings out the fact that DNA damage measured by comet assay was greater in the study group when compared to the control group. As a reflection of uniqueness, this study crowns the scenario with respect to early detection and prevention of potentially malignant disorders and the process of malignant transformation. © 2015 Journal of Pharmacy And Bioallied Sciences | Published by Wolters Kluwer - Medknow. Source

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