Time filter

Source Type

PubMed | Madha Dental College & Hospital, General Dental Practitioner, Madha Dental College and Hospital, University of Technology Malaysia and Rajah Muthiah Dental College and Hospital
Type: Journal Article | Journal: Journal of international oral health : JIOH | Year: 2015

Pseudoepitheliomatous hyperplasia (PEH), a neglected entity by oral pathologist possesses utmost importance in the field of research. Of all the investigative challenges, PEH, a reactive epithelial proliferation is seen secondary to lesions with infectious, inflammatory, reactive, and degenerative origin. Small sized samples, incomplete excision, improper orientation, and dense inflammatory changes render diagnostic confront to the oral pathologist in exclusion of frankly invasive malignant lesions like squamous cell carcinoma from lesions exhibiting PEH. The diagnosis can occasionally be difficult as they mimic other lesions also, on clinic-pathological assessment. Thus, this article gives an insight regarding the various concepts of etiopathogenesis, histopathology, differential diagnosis, and malignant potential of PEH. A combined effort of a clinician and pathologist benefits every patient to rule out malignancy and render appropriate treatment as the only local conservative approach is essential to remove PEH associated lesions.

PubMed | Tagore Dental College and Hospital, Rajas Dental College and Hospital, Madha Dental College and Hospital and Rajah Muthiah Dental College and Hospital
Type: Review | Journal: Journal of pharmacy & bioallied sciences | Year: 2016

A review in affected persons attitude in abstract care of edentulous patients has to be a priority in elderly individuals. The development of complete dentures (CDs) has been the selection of remedy retaining in mind the socioeconomic popularity, age, and nutritional elements. However, most of the patients complain of loss of retention in mandibular implant-supported overdentures (ODs), which compensated the downside of the loss of retention in complete dentures (CDs). Moreover, implant supported over dentures (ISOVDs) supplied accurate exceptional of lifestyles, esthetics, progressed nutritional deficiencies, and provided good patient satisfaction. The place of dental implants and desire of retentive attachments for implant supported mandibular over dentures (ISOVD) are selected on clinician preference and professional opinion. This text offers a fundamental statistics regarding implant placement, mode of treatment to be selected, and patient care. Two implants provide extraordinary long-term achievement and survival with improved oral capabilities. Single midline implant OD is costly, powerful, and may be a promising alternative. In maxilla, 4-6 implants splinted with bar have located to give true results.

PubMed | Indhra Gandhi Institute of Dental science, Educare Institute of Dental science, Vivekanandha Dental College for Women, Madha Dental College and Hospital and 2 more.
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2015

Proteomics is the study of structure and function of proteins in a large scale. For any living organism, preteins are considered to be the vital part because of its role in metabolic pathways of cells. These proteins not only play a role in physiological condition of the cell but also in altered manner during pathologic conditions. These altered proteins in diseased conditions are called as biomarkers. Several such biomarkers were identified in oral diseaes. This review is a brief note on proteins involved in odontogenesis and list of altered proteins proteins identified in various dental and oral diseases. The knowledge about the role of proteomics in dentistry and the importance of proteomic studies in early diagnosis and prognostic part of oral diseases helps in appliction of precised and sucessful treatment.

PubMed | Madha Dental College and Hospital, Rajas Dental College and Hospital and Rajah Muthiah Dental College and Hospital
Type: Review | Journal: Journal of pharmacy & bioallied sciences | Year: 2016

Platelet-rich fibrin (PRF) is a fibrin meshwork, in which platelet cytokines, growth factors, and cells are entrapped and discharged after a period and can serve as a resorbable film. PRF is the next generation of platelet concentrates equipped to improve arrangement without biochemical blood handling; PRF is an evolution of the fibrin adhesive, which is widely used in the oral surgery. The guidelines of this innovation depend on concentrating platelets and growth factors in a plasma medium, and initiating them in a fibrin gel, keeping in mind the end goal to enhance the healing of wounds. Maxillary bone loss requires numerous regenerative techniques: as a supplement to the procedures of tissue regeneration, a platelet concentrate called PRF was tested for the 1

Siddavaram N.,Annamalai University | Ramamurthi V.P.,Annamalai University | Veeran V.,Rajah Muthiah Dental College and Hospital | Mishra R.,Central University of Jharkhand
Cellular Oncology | Year: 2012

Background Chlorophyllin, a water soluble semi-synthetic food-grade derivative is reported to exhibit a wide range of beneficial health effects. We investigated the effect of chlorophyllin supplementation on Wnt/β-catenin and vascular endothelial growth factor (VEGF) signaling in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model. Methods and results Hamsters were divided into 4 groups. The right buccal pouches of group 1 and 2 hamsters were painted with 0.5 % DMBA for 14 weeks. Group 2 animals received in addition chlorophyllin (4 mg/kg bw) in the diet. Group 3 animals received chlorophyllin alone and group 4 animals served as control. mRNA and protein expression of components of Wnt, VEGF, and PI3K/Akt signaling pathways were analyzed by RT-PCR and Western blot analysis. Dietary chlorophyllin administration suppressed the development of HBP carcinomas by altering the expression of several components of the Wnt/β-catenin signaling pathway. This was associated with inhibition of angiogenesis as evidenced by decreased expression of the proangiogenic factors HIF-1α, VEGF, and VEGFR2. Chlorophyllin administration also downregulated the expression of histone deacetylases involved in epigenetic regulation of tumor angiogenesis. Conclusion Dietary chlorophyllin that abrogates Wnt/β-catenin and VEGF signaling by targeting a multitude of key signaling molecules is an attractive candidate for preventing tumor progression. © International Society for Cellular Oncology 2012.

PubMed | Vivekanandha Dental College for Women, Sree Anjaneya Institute of Dental science, Ksr Institute Of Dental Science And Research and Rajah Muthiah Dental College and Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Ameloblastoma holds a unique position among benign tumours by its locally destructive and invasive nature. Recently improvised molecular techniques helped researchers to unravel the myth behind such biologic behaviour. Though interesting findings have been delivered, the rhythmic correlation regarding the exact mechanism still remains lacking. Neurotrophins and their receptor mediated pathways play a crucial role in survival, death and differentiation of many neuroectoderm derived cells. With this background, the study has been aimed to investigate the expression of p75-NTR (Neurotrophin Receptor) in follicular and plexiform ameloblastoma.To analyze the immunohistochemical expression pattern of p75-NTR in ameloblastoma and to compare the immunohistochemical expression pattern of p75-NTR among the histological types of ameloblastoma, follicular and plexiform patterns.Total 22 ameloblastomas (12 follicular, 10 plexiform) were immuno-stained with anti-human p75-NTR mouse IgG monoclonal antibody and the pattern of staining is statistically analyzed.Only 11 (10 follicular, 1 plexiform) out of 22 ameloblastomas showed immuno-reactivity to p75-NTR. In ameloblastoma, only the peripheral pre-ameloblast like tall columnar cells showed reactivity whereas the stellate reticulum-like cells were immuno-negative. The staining pattern was membranous in the immuno-reactive cells. The results were studied with the downstream pathways from the literature and a possible mechanism has been proposed.The expression pattern of p75-NTR was found to be more in follicular ameloblastoma than plexiform.

Varghese S.S.,Mar Baselios Dental College and Hospital | Sunil P.M.,Rajah Muthiah Dental College and Hospital | Madhavan R.N.,Rajah Muthiah Dental College and Hospital
Cancer Biomarkers | Year: 2010

Aims: Prolonged production of the free radical, nitric oxide (NO) by the enzyme inducible nitric oxide synthase (iNOS) plays an important role in tumour progression by promoting angiogenesis, invasion and inducing mutation in tumour suppressor gene. The purpose of this study is to evaluate the expression and intensity of iNOS in normal oral mucosa, precancer and oral squamous cell carcinoma (OSCC). Materials and methods: An immunohistochemical study was performed using rabbit monoclonal antibody to iNOS on archival formalin fixed, paraffin embedded tissues of 5 normal oral mucosal samples, 10 Leukoplakia, 10 oral submucous fibrosis (OSMF) and 15 OSCC of different grades. Results: A statistical significant difference was found between normal oral mucosa, precancer and OSCC in expression of iNOS (p value 0.0015). However, there was no statistically significant difference between the expressions of iNOS within premalignant groups (p value 0.5647) and histological sub-groups of OSCC (p value-0.5647). There was no statistically significant difference in the intensity of iNOS expression within the precancer group, OSCC sub-groups and between precancer and OSCC (p value-0.623). Conclusion: The orderly increase in the expression of iNOS from normal, through precancer, to OSCC suggests the essential role played by iNOS in epithelial transformation and tumour formation. © 2010/2011 - IOS Press and the authors. All rights reserved.

Teja C.S.,SIBAR Institute of Dental science andhra Pradesh | Devy A.S.,SIBAR Institute of Dental science andhra Pradesh | Nirmal R.M.,Indira Gandhi Institute of Dental science | Sunil P.M.,Rajah Muthiah Dental College and Hospital | Deepasree M.,Indira Gandhi Institute of Dental science
CytoJournal | Year: 2014

Background: Tumors are distinguished from normal tissues partly by their pronounced variability of cellular and nuclear dimensions. Therefore, such factors may be an indicator to assess whether the cells are malignant or not. Exfoliative cytology is a reliable tool in assessing such changes in the uterine cervix and has been used in the oral cavity also with success. The aims and objectives of the following study were to evaluate the malignant changes by assessing the quantitative parameters such as cytoplasmic diameter, cytoplasmic perimeter and cytoplasmic area (CD, CP, CA) and nuclear diameter, nuclear perimeter and nuclear area (ND, NP, NA) and cytoplasmic to nuclear ratio in the exfoliated cells of various subtypes of oral lichen planus (OLP) using cytomorphometry. Materials and Methods: Oral exfoliated cells from nineteen cases of histologically proven OLP (1 atrophic, 13 reticular, 4 erosive and 1 plaque) and ten controls with healthy mucosa were taken and stained by Feulgen-Rossenback reaction and cytomorphometric analysis was performed using an image analysis software. The parameters taken into account were CD, CP, CA and ND, NP, NA. Furthermore CA/NA was calculated. The parameters were statistically analyzed using the t-test. Results: Cytomorphometric analysis of all the parameters showed no significant difference between the control group and the reticular/plaque subtypes, whereas statistically significant (P < 0.05) differences was obtained between the control group and the atrophic/erosive subtypes group when compared using t-test. Conclusions: The cytomorphometric analysis of OLP shows that erosive/atrophic subtypes of OLP are at more risk and exfoliative cytology and cytomorphometry can be used as a tool to assess the malignant changes. © 2014 Poflee, et al.; licensee Cytopathology Foundation Inc.

Thangavelu A.,Rajah Muthiah Dental College and Hospital | Vaidhyanathan A.,Rajah Muthiah Dental College and Hospital | Narendar R.,Rajah Muthiah Dental College and Hospital
International Journal of Oral and Maxillofacial Surgery | Year: 2011

Myositis ossificans traumatica (MOT) is a non-neoplastic, heterotopic bone formation within muscle or fascia, presumably due to acute trauma, a burn, surgical manipulation, or repeated injury. A 36-year-old woman presented with progressive limitation of mouth opening over the past 5 months. Computed tomography revealed an irregular ossified mass attached to the medial aspect of the left ramus, extending to the medial and lateral pterygoid plates. MOT of the medial pterygoid is rare, with only four previously reported cases in the English language literature. Surgical excision of the ossification is the main treatment modality. The authors were able to establish a cleavage plane of 3 cm between the bony mass and the medial surface of the ramus. Abdominal fat was placed as an interpositional material to prevent fibrosis and heterotopic bone formation. © 2010 International Association of Oral and Maxillofacial Surgeons.

Thangavelu A.,Rajah Muthiah Dental College and Hospital | Yoganandha R.,Rajah Muthiah Dental College and Hospital | Vaidhyanathan A.,Rajah Muthiah Dental College and Hospital
International Journal of Oral and Maxillofacial Surgery | Year: 2010

Previous retrospective analyses prove that impacted mandibular third molars (M3s) increase the risk of angle fractures and decrease the risk of concomitant fractures to the condyle. The authors have attempted to verify these relationships and identify the underlying mechanism of injury. A retrospective cohort was designed for patients attending the Division of Oral and Maxillofacial Surgery from January 2001 till October 2008. The primary predictor variable was M3. The secondary predictor variables were: M3 position, classified using the Pell and Gregory system; angulation, classified using Shiller's method; and the number of visible dental roots. The outcome variables were angle and condyle fractures. Hospital charts and radiographs were used to determine and classify these variables. The study sample comprised 1102 mandibular fractures in 600 patients. For patients injured by moderate traumatic force resulting in two fractures of the mandible, the presence/absence of impacted M3s played an important role in angle/condylar fractures. Patients with impacted M3s were three times more likely to develop angle fractures and less likely to develop condylar fractures than those without impacted M3s. This study provides clinical evidence to suggest that the removal of unerupted mandibular third molars predisposes the mandible to condyle fractures. © 2010 International Association of Oral and Maxillofacial Surgeons.

Loading Rajah Muthiah Dental College and Hospital collaborators
Loading Rajah Muthiah Dental College and Hospital collaborators