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Reddy G.N.,Vikas Institute of Phannaceutical science | Ramesh C.,VV Pura Institute of Pharmaceutical science | Narayana T.V.,Vikas Institute of Phannaceutical science | Prasada Rao K.V.S.,Rahul Institute of Pharmaceutical science and Research | Rao B.G.,Andhra University
Rasayan Journal of Chemistry | Year: 2011

Simple spectrophotometric methods (A-C) for the assay of Imipramine hydrochloride (IMP) based on the formation of its complexes with alkaloidal precipitants are described. IMP undergo quantitative precipitation in the form of molecular complexes with iodine (I2, method A), ammonium molybdate (AM, method B) or phosphomolybdic acid (PMA, method C) when used in excess. In addition to precipitation reactions, color reactions havealso been combined to estimate IMP. They are based on the color formation with either un-reacted precipitant of the filtrate (in I2) or released precipitant from the molecular complex (in AM or PMA) with chromogenic reagent such as P-N-methyl amino phenol sulphate (PMAP)-sulphanilic acid (SAc) (for I2), potassium thiocyanate (PTC) (for AM), cobalt nitrate (Co(H))-disodium salt of ethylene diamine terra acetic acid (EDTA) complex (for PMA). © 2011 RASAYAN. Source


Ramesh C.,VV Pura Institute of Pharmaceutical science | Narayana T.V.,Vignan Institute of Pharmaceutical Sciences | Prasada Rao K.V.S.,Rahul Institute of Pharmaceutical science and Research | Ganga Rao B.,Andhra University
Oriental Journal of Chemistry | Year: 2011

Three simple sensitive and reproducible visible spectrophotometric methods (A, B, and C) for the determination of Naratriptan hydrochloride (NTP) in bulk samples and pharmaceutical formulations are described. Method A is based on the formation of colored co-ordination complex with cobalt thiocyanate (CTC). Method B is based on the formation of colored species with citric acid - acetic anhydride (CiA-Ac2O). Method C based on the formation of colored molecular complex involving NTP and sodium nitroprusside (SNP) in the presence of hydroxylamine mono hydrochloride (HA). Regression analysis of Beer's law plots showed good concentration ranges 5-35, 2-10 and 10-60 μg mL -1 for methods A, B and C respectively. The applicability of the methods was examined by analyzing tablets of NTP. Source


Ramesh C.,Vvpura Institute Of Pharmaceutical Science | Narayana T.V.,Vignan Institute of Pharmaceutical Sciences | Prasada Rao K.V.S.,Rahul Institute of Pharmaceutical science and Research | Ganaga Rao B.,Andhra University
Research Journal of Pharmacy and Technology | Year: 2011

Four simple and sensitive spectrophotometric methods (A - D) for the assay of naratriptan hydrochloride in pure and dosage forms based on the formation of chloroform soluble ion-associates under specified experimental conditions are described. Four acidic dyes, namely, wool fast Blue (WFB BL, method A), orange II (Tpooo, method B), Naphthalene Blue 12 BR (NB-12BR, method C), and Azocarmine (AG, method D) are utilized. The extracts of the ion-associates exhibit absorption maxima at 580, 480, 630 and 540 nm for methods A, B, C and D, respectively. Beer's law and the precision and accuracy of the methods are checked by the UV reference. © RJPT All right reserved. Source


Jithendra R.,Rahul Institute of Pharmaceutical science and Research
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

A reverse Phase high performance liquid chromatographic method was developed for the determination of Cefoxitin Sodium in Pharmaceutical dosage form. The separation was effected on Zorbax SB Phenyl column (150mm x 4.6 mm, 5.0μ) using a mobile phase mixture of 0.01Msodium dihydrogen orthophosphate and methanol in the ratio of 70:30 v/v at a flow rate of 1.5 ml/min. the detection was made at 254nm. The retention time of Cefoxitin sodium was found to be 8.59 min. Calibration curve was linear over the concentration range of 75 to 225μg/ml. The proposed method was validated as per the ICH guidelines. The method was accurate and precise and found to be suitable for the quantitative analysis of the drug in injection dosage form. Source


Ramesh C.,Vvpura Institute Of Pharmaceutical Science | Narayana T.V.,Vignan Institute of Pharmaceutical Sciences | Prasada Rao K.V.S.,Rahul Institute of Pharmaceutical science and Research | Ganaga Rao B.,Andhra University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Three simple and sensitive visible spectrophotometric methods (M 1, M 2, and M 3) have been described for the estimation of Guanfacine (GUN). The methods are based on the formation of radical anion with the involvement of basic nitrogen in GUN (donor) and quinones [2,3-dichloro-5,6-dicyano-p-benzoquinone(DDQ), chloranilic acid (DHQ), 2,3,5,6-tetrachloro-p-benzoquinone (TQ)] (acceptor). The variable parameters in all these methods have been optimized and the chemical reactions involved are presented. The results obtained in the three methods are statistically validated and recoveries range from 99.7 to 100.3%. Common excipients used in additives in pharmaceutical preparations do not interfere in the proposed methods. Source

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