Rahul Institute of Pharmaceutical science and Research

India

Rahul Institute of Pharmaceutical science and Research

India
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Reddy G.N.,P.A. College | Ramesh C.,V V Pura Institute Of Pharmaceutical Science | Narayana T.V.,Vignan Institute of Pharmaceutical Sciences | Rao K.V.S.P.,Rahul Institute of Pharmaceutical science and Research | Rao B.G.,Andhra University
International Journal of Chemical Sciences | Year: 2011

Three simple and sensitive spectrophotometric methods (M1-M3) for the assay of imipramine in pure and dosage forms based on the formation of chloroform soluble ion-associates under specified experimental conditions are described. Three acidic dyes, namely, azocarmine G (ACG, M1), naphthalene blue 12BR (NB 12BR, M2) and woolfast blue BL (WFB BL, M3) are utilized. The extracts of the ionassociates exhibit absorption maxima at 550, 620 and 590 nm for methods M1, M2 and M3, respectively. Regression analysis of Beer's law plots showed good correlation in the concentration ranges 2.0-12.0, 4.0-16.0 and 1.0-12.0 μg/mL for methods M1, M2 and M3, respectively. These methods are found to be suitable for the assay of imipramine in pharmaceutical formulations. All the variables have been optimized and the reaction mechanisms presented. The concentration measurements are reproducible within a relative standard deviation of 1.0%.


Ramesh C.,Vignan Institute of Pharmaceutical Sciences | Narayana T.V.,Vignan Institute of Pharmaceutical Sciences | Prasada Rao K.V.S.,Rahul Institute of Pharmaceutical science and Research | Ganga Rao B.,Andhra University
Rasayan Journal of Chemistry | Year: 2011

Four simple and sensitive visible spectrophotometric methods (A, B, and C) have been described for the estimation of Cefprozil (CEF). The methods that are based on the formation of radical anion with the involvement of basic nitrogen in CEF (donor) and quinones [2,3-dichloro-5,6-dicyano-p-benzoquinone(DDQ), chloranilic acid (DHQ), 2,3,5,6-tetrachloro-p-benzoquinone (TQ)] (acceptor). The variable parameters in all these methods have been optimized and the chemical reactions involved are presented. The results obtained in the three methods are statistically validated and recoveries range from 99.7 to 101.3%. Common excipients used in additives in pharmaceutical preparations do not interfere in the proposed methods. copy; 2011 RASAYAN.


Ramesh C.,Vv Pura Institute Of Pharmaceutical Science | Narayana T.V.,Vignan Institute of Pharmaceutical Sciences | Prasada Rao K.V.S.,Rahul Institute of Pharmaceutical science and Research | Ganga Rao B.,Andhra University
Oriental Journal of Chemistry | Year: 2011

Three simple sensitive and reproducible visible spectrophotometric methods (A, B, and C) for the determination of Naratriptan hydrochloride (NTP) in bulk samples and pharmaceutical formulations are described. Method A is based on the formation of colored co-ordination complex with cobalt thiocyanate (CTC). Method B is based on the formation of colored species with citric acid - acetic anhydride (CiA-Ac2O). Method C based on the formation of colored molecular complex involving NTP and sodium nitroprusside (SNP) in the presence of hydroxylamine mono hydrochloride (HA). Regression analysis of Beer's law plots showed good concentration ranges 5-35, 2-10 and 10-60 μg mL -1 for methods A, B and C respectively. The applicability of the methods was examined by analyzing tablets of NTP.


Jithendra R.,Rahul Institute of Pharmaceutical science and Research
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

A reverse Phase high performance liquid chromatographic method was developed for the determination of Cefoxitin Sodium in Pharmaceutical dosage form. The separation was effected on Zorbax SB Phenyl column (150mm x 4.6 mm, 5.0μ) using a mobile phase mixture of 0.01Msodium dihydrogen orthophosphate and methanol in the ratio of 70:30 v/v at a flow rate of 1.5 ml/min. the detection was made at 254nm. The retention time of Cefoxitin sodium was found to be 8.59 min. Calibration curve was linear over the concentration range of 75 to 225μg/ml. The proposed method was validated as per the ICH guidelines. The method was accurate and precise and found to be suitable for the quantitative analysis of the drug in injection dosage form.


Dinesh Kumar P.,Rahul Institute of Pharmaceutical Science and Research | Prakash C.R.,Rahul Institute of Pharmaceutical Science and Research | Saravanan G.,Medicinal Chemistry Research Laboratory | Karthick V.,Rahul Institute of Pharmaceutical Science and Research | Selvam Panneer T.,Rahul Institute of Pharmaceutical Science and Research
Rasayan Journal of Chemistry | Year: 2010

The purpose of this study is to prepare a bilayer gastro retentive tablet of ranitidine using direct compression technology and optimize the type and concentration of polymer to give maximum retentive effect with good drug release profile. Ranitidine H2 receptor antagonist having short biological half life (2-3.5 h), absorption in the initial part of the small intestine and 50% absolute bioavailability of drug favor development of sustained release floating formulation. In this study, a bilayer tablet was prepared which contains an immediate release portion and a floating layer. HPMC-K-100, HPMC-K-4M, HPMC-E-15, CARBOPOL-934 were used as gel forming agents either alone or in combination. Sodium bicarbonate, and citric acid as gas generating agent, lactose as additive combine with the polymer to form the floating layer1. The bilayer tablets were characterized by lag time, floating time, weight variation, drug content and dissolution profile. Best Formulation BLF6 [HPMC-K100 (1:1)] shows lag time of 25 s, floating time of 24 h and drug release of 99.85%. The best formulation was taken up for animal studies as approved by Institutional Animal Ethical Committee. The X-ray studies for floating properties of tablet and the in vivo bioavailability studies for the formulation was carried out using rabbits which showed a significant increase in bioavailability of drug as compared with conventional dosage forms. The optimized formulation was subjected to stability studies at 40 ± 2° and 75 ± 5% RH for period of three months. Short term stability studies were carried for optimized formulation showed good result.


Pandurangan D.K.,Rahul Institute of Pharmaceutical Science and Research | Mounika S.K.,Rahul Institute of Pharmaceutical Science and Research
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

Quantum dot is a portion of matter whose excitons are confined in all three spatial dimensions. These thus have electronic properties intermediate between those of bulk semiconductors and those of discrete molecules. The surface modification of QDs with antibodies, aptamers, peptides, or small molecules that bind to antigens present on the target cells or tissues has resulted in the development of sensitive and specific targeted imaging and diagnostic modalities. Recently, QDs have been engineered to carry distinct classes of therapeutic agents for simultaneous imaging and therapeutic applications and medilgcal applications. QD's are recently afflicted to contamination of aquatic and terrestrial ecosystems. In this review we gave general consideration to methods of production of quantum dots, non pharmaceutical and pharmaceutical applications and limitations.


Stalin C.,Rahul Institute of Pharmaceutical science and Research | Dineshkumar P.,Rahul Institute of Pharmaceutical science and Research
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

Aptamers, also termed as "decoys" or "chemical antibodies," represent an emerging class of therapeutics. They are short DNA or RNA oligonucleotides or peptides that assume a specific and stable three-dimensional shape in vivo, thereby providing specific tight binding to protein targets. In some cases and as opposed to antisense oligonucleotides, effects can be mediated against extracellular targets, thereby preventing a need for intracellular transportation. In the simplest view, Aptamers can be thought of as nucleic acid analogs to antibodies. Aptamers have wide application in many areas of biomedical sciences such as-Purification processes, Target validation, Drug development diagnostics, and MRI-based cell tracking therapy. Combining Nano biotechnology with Aptamers opens the way for more sophisticated applications in molecular diagnosis. Moreover, Aptamers are used to study regulatory circuits and molecular mechanisms of disease processes. Aptamers can readily be adopted for analytical or diagnostic applications. In vivo experiments demonstrate that they generally exhibit low toxicity and immunogenicity characteristics, which make them suitable for therapeutic use. This article presents a view of recent developments in Systematic Evolution of Ligands by Exponential enrichment (SELEX) technologies and new emerging applications of Aptamers.


Pandurangan D.K.,Acharya Nagarjuna University | Vuyyuru T.,Acharya Nagarjuna University | Kollipara D.,Rahul Institute of Pharmaceutical Science and Research
International Journal of Research in Pharmaceutical Sciences | Year: 2012

Despite disadvantage, oral drug delivery remains the preferred route of drug delivery. Oral fast dissolving tablets have received important acceptance as novel drug delivery system for treatment of various diseases upon introduction in the mouth disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. This article provides comprehensive review of fast dissolving tablets. © JK Welfare & Pharmascope Foundation.


Reddy G.N.,Vikas Institute of Phannaceutical science | Ramesh C.,VV Pura Institute of Pharmaceutical science | Narayana T.V.,Vikas Institute of Phannaceutical science | Prasada Rao K.V.S.,Rahul Institute of Pharmaceutical science and Research | Rao B.G.,Andhra University
Rasayan Journal of Chemistry | Year: 2011

Simple spectrophotometric methods (A-C) for the assay of Imipramine hydrochloride (IMP) based on the formation of its complexes with alkaloidal precipitants are described. IMP undergo quantitative precipitation in the form of molecular complexes with iodine (I2, method A), ammonium molybdate (AM, method B) or phosphomolybdic acid (PMA, method C) when used in excess. In addition to precipitation reactions, color reactions havealso been combined to estimate IMP. They are based on the color formation with either un-reacted precipitant of the filtrate (in I2) or released precipitant from the molecular complex (in AM or PMA) with chromogenic reagent such as P-N-methyl amino phenol sulphate (PMAP)-sulphanilic acid (SAc) (for I2), potassium thiocyanate (PTC) (for AM), cobalt nitrate (Co(H))-disodium salt of ethylene diamine terra acetic acid (EDTA) complex (for PMA). © 2011 RASAYAN.


Stalin C.,Rahul Institute of Pharmaceutical science and Research | Dineshkumar P.,Rahul Institute of Pharmaceutical science and Research | Nithiyananthan K.,Rahul Institute of Pharmaceutical science and Research
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Ficus carica Linn. (Moraceae) is commonly known as Edible fig. The leaves, roots, fruits and latex of the plant are medicinally used in different diseases. In traditional medicine the roots are used in treatment of leucoderma and ringworms and its fruits which are sweet, have antipyretic, purgative, aphrodisiac properties and have shown to be useful in inflammations and paralysis. The Present investigation was carried out to study the antidiabetic effect of the methanolic extract of Ficus carica (MEFC) in alloxan induced diabetic rats. The LD50 determination was done in mice as per OECD guidelines 423. The rats were divided into five groups. Diabetes was induced using alloxan and the treatment was continued for 21 days using Metformin (500 mg/kg p.o) as a standard drug. Blood glucose level, bodyweight, biochemical parameters and histopathological observation were done. The methanolic extract (200 mg/kg p.o) had shown significant (p < 0.01) antidiabetic activity than (100 mg/kg p.o) by showing a reduction in blood glucose levels and triglycerides compared to pretreatment levels. The results indicate that, methanolic extract of Ficus carica have prominent antidiabetic effect and can therefore be used as an alternative remedy for the treatment of diabetes mellitus and its complications.

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