PubMed | MNR Dental College & Hospital, Ragas Dental College, Malla Reddy Institute of Dental science and Sb Patil Dental College And Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016
Among all neoplasms affecting head and neck region, salivary gland neoplasms are rare. Pleomorphic adenomas are the most common benign salivary gland tumours making up to 50% of major and minor salivary gland tumours. Intraorally pleomorphic adenoma is mostly found on palate and lips and very rarely in retromolar area. Here we are reporting a rare case of pleomorphic adenoma in right lower retromolar area in a 31-year-old female, the lesion was excised in toto with safety margins under local anaesthesia and postoperative follow up after six months didnt showed any recurrence.
Ebenezar J.,Anna University |
Ebenezar J.,Jamal Mohamed College Autonomous |
Ganesan S.,Anna University |
Aruna P.,Anna University |
And 3 more authors.
Journal of Biomedical Optics | Year: 2012
Fluorescence excitation spectroscopy (FES) is an emerging approach to cancer detection. The goal of this pilot study is to evaluate the diagnostic potential of FES technique for the detection and characterization of normal and cancerous oral lesions in vivo. Fluorescence excitation (FE) spectra from oral mucosa were recorded in the spectral range of 340 to 600 nm at 635 nm emission using a fiberoptic probe spectrofluorometer to obtain spectra from the buccal mucosa of 30 sites of 15 healthy volunteers and 15 sites of 10 cancerous patients. Significant FE spectral differences were observed between normal and well differentiated squamous cell carcinoma (WDSCC) oral lesions. The FE spectra of healthy volunteers consists of a broad emission band around 440 to 470 nm, whereas in WDSCC lesions, a new primary peak was seen at 410 nm with secondary peaks observed at 505, 540, and 580 nm due to the accumulation of porphyrins in oral lesions. The FE spectral bands of the WDSCC lesions resemble the typical absorption spectra of a porphyrin. Three potential ratios (I410/ I505, I410/I540, and I410/I 580) were calculated from the FE spectra and used as input variables for a stepwise linear discriminant analysis (SLDA) for normal and WDSCC groups. Leave-one-out (LOO) method of cross-validation was performed to check the reliability on spectral data for tissue characterization. The diagnostic sensitivity and specificity were determined for normal and WDSCC lesions from the scatter plot of the discriminant function scores. It was observed that diagnostic algorithm based on discriminant function scores obtained by SLDA-LOO method was able to distinguish WDSCC from normal lesions with a sensitivity of 100% and specificity of 100%. Results of the pilot study demonstrate that the FE spectral changes due to porphyrin have a good diagnostic potential; therefore, porphyrin can be used as a native tumor marker. © 2012 Society of Photo-Optical Instrumentation Engineers (SPIE).
Varghese S.,Sri Ramachandra Dental College |
Kailasam V.,Sri Ramachandra Dental College |
Padmanabhan S.,Sri Ramachandra Dental College |
Vikraman B.,Ragas Dental College |
Chithranjan A.,Sri Ramachandra Dental College
Dentomaxillofacial Radiology | Year: 2010
Objectives: The aim of the study was to evaluate the accuracy of linear measurements obtained from reconstructed spiral CT images of human dry skulls in three planes by comparing them with direct skull measurements, and then to compare these with measurements made on photostimulable phosphor cephalograms. Methods: Using a Siemens Somatom Sensation spiral CT scanner (Munich, Germany), CT images of six human dry skulls were imported into imaging software (Mimics 11.02 Materialise, Leuven, Belgium) and the measurements made were compared to the direct measurements made using a digital calliper (500-171, CD-6C, Mitutoyo, Kawasaki, Japan). The measurements were also compared to those made on frontal and lateral cephalograms taken using a digital cephalostat (Planmeca Oy, Helsinki, Finland). The mean of the 15 linear measurements obtained were compared using the paired Student's t-test. Results: CT measurements did not show a significant difference from the direct skull measurements (P < 0.05) in all three planes except for two midsagittal measurements in the anteroposterior plane. Cephalometric measurements were comparable to direct skull measurements for midsagittal measurements in the anteroposterior plane, but showed a significant difference when bilateral measurements were considered. Cephalometric measurements also showed a significant difference in the transverse plane from direct measurements and CT measurements; however, they did not display a significant difference between direct skullmeasurements andCTmeasurements for most parameters in the vertical plane. Conclusion: Linear measurements on the spiral CT were comparable to anatomical measurements and were more reliable than cephalometric measurements. Cephalometric measurements were acceptable for midsagittal measurements in the anteroposterior plane, but showed a significant variation from anatomical and CT measurements in most other parameters. © 2010 The British Institute of Radiology.
Kalyanasundaram A.P.,Tamil University |
Jacob S.M.,Tamil University |
Hemalatha R.,Ragas Dental College |
Sivakumar M.R.,Tamil University
Journal of the International Association of Physicians in AIDS Care | Year: 2012
As antiretroviral therapy (ART) becomes more available to the HIV-infected population, it is important to determine the prevalence of its long-term complications. In this cross-sectional study, 145 HIV-positive patients on ART, 146 HIV-positive patients not on ART, and 72 HIV-negative individuals visiting the Namakkal District Head Quarters Hospital, Tamil Nadu, India, were recruited from February 2007 to April 2009. Among the patients on ART, the prevalence of lipodystrophy was 60.7%; 22.7% with lipohypertrophy, 51.1% with lipoatrophy, and 22.7% with mixed pattern. The proportion of patients with dyslipidemia was significantly higher in the treatment group when compared to ART-naive and HIV-negative controls (P =.00). Total duration of ART was significantly associated with lipodystrophy (P =.04) and dyslipidemia (P =.01). Also, by logistic regression, abnormal metabolic levels were a risk factor in lipodystrophy (P =.02). This study highlights the need for development of inexpensive and accessible treatments for the reduction of lipodystrophy. © SAGE Publications 2011.
Sashikumar R.,Sri Ramachandra University |
Kannan R.,Ragas Dental College
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology | Year: 2010
Objective: The aim of this study was to detect salivary glucose levels in diabetic and nondiabetic subjects, to study the relationship between salivary glucose levels and salivary candidal carriage, and to determine if salivary glucose levels could be used as a noninvasive tool to monitor glycemic control in diabetics. Study design: A total of 150 adults, 100 with type 2 diabetes and 50 without diabetes (control subjects), aged 40-60 years, participated in the study. Diabetic status was determined by estimation of random nonfasting plasma glucose levels and glycosylated hemoglobin levels. Both unstimulated and stimulated saliva were collected and investigated for glucose levels and colony-forming units (CFU) of Candida. Salivary glucose levels were measured using the glucose-oxidase method. Results: Salivary glucose levels were significantly higher in diabetics than nondiabetics. There was a significant positive correlation between salivary and plasma glucose levels. Candidal CFUs were significantly higher in diabetic subjects and showed a significant positive correlation with salivary (unstimulated and stimulated) glucose levels. Conclusions: These results show that salivary glucose concentration is a potentially useful noninvasive tool to monitor glycemic control in diabetic patients. Increased salivary glucose is associated with increased prevalence of oral Candida in these subjects. © 2010 Mosby, Inc. All rights reserved.
Umadevi K.R.,Ragas Dental College
Advances in dental research | Year: 2011
The oral research community needs an understanding of the social causes, consequences, and costs of disease in relation to oral health. This workshop concluded that HIV infection constitutes a special dental need requiring specific arrangements to facilitate oral care for infected persons. Oral manifestations of HIV infection affect everyday life, but more evidence is needed on the effects of interventions to alleviate these impacts. Other oral health habits add to the burden of HIV/AIDS-associated oral diseases and compete with them for resources. These problems are most acute where the prevalence of HIV is high and resources are scarce. Effective health promotion is therefore important in these areas. Without data on the utility of oral health care in developing countries, practical approaches are guided by societal and multidisciplinary principles. There are also important ethical considerations.
Lovelina F.D.,Ragas Dental College
Oral health & preventive dentistry | Year: 2012
To assess the oral health status and concordance between monozygotic and dizygotic twin pairs. After obtaining prior consent, a cross-sectional descriptive study was conducted among 9 monozygotic and 21 dizygotic twin pairs who were reared together. Perception towards oral health practices was assessed using a pre-tested questionnaire. The WHO oral health assessment form (1997) was employed to assess the oral health status. Zygosity determination was determined using the medical records, dermatoglyphics and details about chorionicity and number of placental cords. Pearson's correlation was calculated to determine the correlation among the monozygotic and dizygotic twin pairs. The monozygotic twin pairs showed a greater correlation compared to the dizygotic twin pairs in dental caries, periodontal disease and malocclusion. In the present study, monozygotic twin pairs showed a higher correlation rate than the dizygotic twin pairs, suggesting considerable evidence that genes play a significant role in the aetiology of dental caries, periodontal disease and malocclusion.
George A.,Mar Baselios Dental College |
Ranganathan K.,Ragas Dental College |
Rao U.K.,Ragas Dental College
Cancer Biomarkers | Year: 2010
Introduction: Oral Cancer (OC) is the sixth most common cancer worldwide, while being the most common cancer among Indian males and the third most common cause of their deaths. 70-94% of all the malignancies arising within the oral cavity are oral squamous cell carcinomas (OSCC). Researches show that altered expression of matrix metalloproteinases (MMPs) may have a vital role in regulating the tumor microenvironment of head and neck carcinomas. Aim: To evaluate the expression of MMP-1 in histopathologically different grades of OSCC, to evaluate its expression in normal buccal mucosa (NBM), and to compare the expressions between these two groups, using the streptavidin horseradish peroxidase biotin labeled immuno-histochemistry (IHC) technique. Result: 100% of OSCC showed cytoplasmic immune reactivity for MMP-1 in the epithelial and connective tissue cells. Their expression was elevated as the histopathological grade differed from well to poorly differentiated. 100% of epithelial cells and 80% of connective tissue of NBM expressed MMP-1.The immune reactivity was significantly over-expressed in OSCC in comparison to NBM. Conclusion: Evidence indicates that the elevated MMP-1 protein expression is associated with higher histopathological grade of OSCC. NBM express MMP-1 diffusely and weakly. MMP-1 immune reactivity increases as OC progresses from NBM to well to poorly differentiated OSCC. © 2010 - IOS Press and the authors. All rights reserved.
Poorni S.,Ragas Dental College |
Karumaran C.S.,Ragas Dental College |
Indira R.,Ragas Dental College
Australian Endodontic Journal | Year: 2010
This case report presents a relatively uncommon clinical case of a mandibular premolar with two roots and three canals. The possibility of additional root canals should be considered even in teeth with a low frequency of abnormal root canal anatomy. Sound knowledge of root canal anatomy, appropriate assessment of the pulp chamber oor, critical interpretation of radiographs and high-magnication examinations are highly desirable to achieve the best possible outcome in complicated root canal therapy. © 2009 The Authors. Journal compilation © 2009 Australian Society of Endodontology.
Lavanya N.,Ragas Dental College |
Jayanthi P.,Ragas Dental College |
Rao U.,Ragas Dental College |
Ranganathan K.,Ragas Dental College
Journal of Oral and Maxillofacial Pathology | Year: 2011
Oral lichen planus (OLP) is a chronic inflammatory disease that affects the mucus membrane of the oral cavity. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+ T cells trigger apoptosis of the basal cells of the oral epithelium. Several antigen-specific and nonspecific inflammatory mechanisms have been put forward to explain the accumulation and homing of CD8+ T cells subepithelially and the subsequent keratinocyte apoptosis. A wide spectrum of treatment modalities is available, from topical corticosteroids to laser ablation of the lesion. In this review, we discuss the various concepts in the pathogenesis and current treatment modalities of OLP.