Entity

Time filter

Source Type


Dong G.,Radiotherapy Central of PLA 404 Hospital | Wang D.,Radiotherapy Central of PLA 404 Hospital | Liang X.,Breast Surgery Women in Weihai City Childrens Hospital | Gao H.,Radiotherapy Central of PLA 404 Hospital | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2014

This study is to analyze the relationship between clinical parameters and prognosis and survival rates of breast cancer patients. A total of 1541 cases of breast cancer were retrospectively reviewed with respect to clinical parameters and the correlation with prognosis and survival rates. Among these patients, follow-up investigation was performed for 1381 cases. Clinical parameters including disease sites (the lesion quadrant), incidences, the number of axillary lymph node metastasis, maximum diameter of tumor, tumor regional lymph node metastasis (TNM) stages, pathological types were investigated. The estrogen receptor, progesterone receptor, Human Epidermal Growth Factor Receptor-2 levels were correlated with long term disease-free survival. Lymph node metastases, tumor diameter, TNM stage, and hormone receptor status are correlated with survival rates of breast cancer patients. © 2014 E-Century Publishing Corporation. All rights reserved. Source


Dong G.,Radiotherapy Central of PLA 404 Hospital | Liang X.,Breast Surgery Women in Weihai City Childrens Hospital | Wang D.,Radiotherapy Central of PLA 404 Hospital | Gao H.,Radiotherapy Central of PLA 404 Hospital | And 4 more authors.
Medical Oncology | Year: 2014

The triple-negative breast cancer (TNBC), with a particularly poor prognosis, is increasingly recognized as heterogeneous in molecular signatures. MicroRNA expression profiles have been used for the classification and prognostication of breast cancer, numerous significantly upregulated microRNAs, i.e. miR-21, have been verified oncogenic in non-TNBCs. In present study, we determined the miR-21 levels in TNBC specimens, and TNBC cell levels in vitro, and then identified the role of miR-21 on tumor cell proliferation, apoptosis, and then identified PTEN as the possible target of the microRNA. It was shown that miR-21 expression is upregulated generally, and heterogeneous in TNBC specimens, posing a correlation with poor prognosis for TNBC patients. Further results demonstrated that the upregulated miR-21 promoted the tumor proliferation and inhibited cell apoptosis in vitro. And pro-apoptotic PTEN had been shown being targeted and downregulated. Therefore, our finding emphasized the oncogenic role of miR-21 in TNBC. © 2014 Springer Science+Business Media. Source

Discover hidden collaborations