Nuclear Medicine and Radiotherapy

Essen, Germany

Nuclear Medicine and Radiotherapy

Essen, Germany
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Jo P.,University Medical Center Goettingen | Azizian A.,University Medical Center Goettingen | Salendo J.,University Medical Center Goettingen | Kramer F.,University Medical Center Goettingen | And 7 more authors.
International Journal of Molecular Sciences | Year: 2017

Since the response to chemoradiotherapy in patients with locally advanced rectal cancer is heterogeneous, valid biomarkers are needed to monitor tumor response. Circulating microRNAs are promising candidates, however analyses of circulating microRNAs in rectal cancer are still rare. 111 patients with rectal cancer and 46 age-matched normal controls were enrolled. The expression levels of 30 microRNAs were analyzed in 17 pre-treatment patients’ plasma samples. Differentially regulated microRNAs were validated in 94 independent patients. For 52 of the 94 patients a paired comparison between pre-treatment and post-treatment samples was performed. miR-17, miR-18b, miR-20a, miR-31, and miR-193a_3p, were significantly downregulated in pre-treatment plasma samples of patients with rectal cancer (p < 0.05). miR-29c, miR-30c, and miR-195 showed a trend of differential regulation. After validation, miR-31 and miR-30c were significantly deregulated by a decrease of expression. In 52 patients expression analyses of the 8 microRNAs in matched pre-treatment and post-treatment samples showed a significant decrease for all microRNAs (p < 0.05) after treatment. Expression levels of miR-31 and miR-30c could serve as valid biomarkers if validated in a prospective study. Plasma microRNA expression levels do not necessarily represent miRNA expression levels in tumor tissue. Also, expression levels of microRNAs change during multimodal therapy. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.


Timmermann J.,St Josef Hospital | Hahn M.,ARTIMED Medical Consulting GmbH | Krueger K.,Nuclear Medicine and Radiotherapy
Journal of Back and Musculoskeletal Rehabilitation | Year: 2011

Aim: The purpose of this article is to present the clinical results of percutaneous nucleotomy treatment on patients with cervical disk herniation. Methods: Patients with long-term chronic pain due to either cervical prolapse or protrusion were recruited for cervical nucleotomy. The surgical procedures were performed between mid-2008 and the beginning of 2009. The purpose of the surgeries was to relieve radicular irritation and reduce the chronic, high level of pain by micro-technically withdrawing herniated nucleus pulposus tissue. Results: After the percutaneous nucleotomy, the patients were hospitalized for an average of 3 to 4 days. In all complete documented cases (57.5%) the pain was substantially reduced. Conclusion: Cervical percutaneous nucleotomy is a © 2011 - IOS Press and the authors. All rights reserved.promising alternative to traditional open disk surgery or to chemonucleolysis for herniated disks of the cervical spine. © 2011 - IOS Press and the authors. All rights reserved.

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