Hamadān, Iran
Hamadān, Iran

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Hajihosseini M.,Hamadan University of Medical Sciences | Amini P.,Royan Institute for Reproductive Biomedicine | Shahdoust M.,Hamadan University of Medical Sciences | Faradmal J.,Hamadan University of Medical Sciences | And 2 more authors.
Koomesh | Year: 2016

Introduction: Determining disease progression process and its affecting factors are of the most important issues in controlling the disease. This study aimed to predict the breast cancer progression as well as assessing the relationship between demographical and clinical factors. Materials and Methods: This retrospective cohort study was conducted on 527 Iranian females with breast cancer who underwent surgery, from 1995 to 2013 using checklists. The effect of the factors on death and tumor recurrence was assessed by log-normal model fitted into each transition of illness-death model which were used to investigate the relationship between demographic and clinical factors and survival time. Data analysis was performed using statistical R software version 3.1.1. The significance level of 0.05 was considered. Results: Evaluating the hazard of death without recurrence, the risk of death in patients over 50 years were higher than those under 50 (P=0.01). A tumor size of 2-5 cm was introduced as a death factor in recurrent patients (P=0.01).Age and type of tumor did not impact the hazard. Log-normal distribution was chosen for downtime between steps. Conclusion: Based on the results, age at diagnosis had significant impact on the risk of death before the first recurrence. Tumor size had a significant effect on death after tumor recurrence. In addition, Log-normal and disability models are appropriate tools to identify the factors influencing survival of patients with breast cancer. © 2016, Semnan University of Medical Sciences. All rights reserved.


Faradmal J.,Hamadan University of Medical Sciences | Roshanaei G.,Hamadan University of Medical Sciences | Mafi M.,Hamadan University of Medical Sciences | Sadighi-Pashaki A.,Radiology Oncology Center | Karami M.,Hamadan University of Medical Sciences
Journal of Research in Health Sciences | Year: 2016

Background: The occurrence and the mortality related to breast cancer (BC) in Iranian female population has increased over time. Although there are many studies on BC and related risk factors, however, the epidemiological aspects of this melanoma in Iranian females are uncertain. Therefore, the aim of this study was to determine the relationship between demographical and clinical factors on the shape of overall survival (OS) distribution in patients with BC. Methods: This historical cohort study was carried out using data from 522 participants with BC. Data were gathered from medical records of these patients admitted to Mahdieh Oncology Center of Hamadan Province, western Iran, from January 2000 to August 2011. Kaplan-Meier estimator was used to estimate the survival rates and, censored quantile regression (CQR) to provide in-depth insight in the multivariable association between prognosis factors and survival rates. Results: Patients' follow-up ranged from around 3 to 197 months. One-, three-, and five-year survival rates were 90%, 73% and 62.5%, respectively. Results of CQR model showed that change in the age at diagnosis, number of involved lymph nodes and tumor size could significantly change the median and some other quantiles of OS. Conclusions: This study, confirm the importance of early detection of BC and usefulness of CQR because of possible changes in distribution family of survival time. © 2016, Health Hamadan University of Medical Sciences. All rights reserved.


Fardmal J.,Hamadan University of Medical Sciences | Mafi M.,Hamadan University of Medical Sciences | Sadighi-Pashaki A.,Radiology Oncology Center | Karami M.,Hamadan University of Medical Sciences | Roshanaei G.H.,Hamadan University of Medical Sciences
Journal of Zanjan University of Medical Sciences and Health Services | Year: 2013

Background and Objective: Breast cancer is the most common cancer among women. Various factors are associated with survival of patients with breast cancer. The aim of this study was to determine the survival rate of patients with breast cancer who referred to MRI center of Hamadan and to explore its related factors. Materials and Methods: In this historical cohort study, 542 women with breast cancer who had referred to Darol-Aitam-e Mahdieh center of Hamadan were included during 2004-2011. All patients had undergone chemotherapy and radiotherapy after surgery. Data were obtained from the patients' medical records and were analyzed using time-dependent Cox model. Results: The mean (SD) age of patients was 46.06 (±10.82) years. The median of survival time was 109.7 months. 201 (37.1%) patients died during the study period. One, five and ten-year survival of the patients was 96.8%, 68% and 31%, respectively. The results of the current study showed that the tumor size and metastasis status were statistically related to the hazard of death in these patients (p<0.05). Conclusion: Age, metastasis status, tumor size, number of involved lymph nodes and the status of progesterone receptor were associated with survival of patients. Since early detection of breast cancer may have an influence on some of these factors, therefore, these results reveals the important role of public education for regular referral to physicians and screening of breast cancer for all women for early detection of breast cancer.


PubMed | Radiology Oncology Center and Hamadan University of Medical Sciences
Type: Journal Article | Journal: Journal of research in health sciences | Year: 2016

The occurrence and the mortality related to breast cancer (BC) in Iranian female population has increased over time. Although there are many studies on BC and related risk factors, however, the epidemiological aspects of this melanoma in Iranian females are uncertain. Therefore, the aim of this study was to determine the relationship between demographical and clinical factors on the shape of overall survival (OS) distribution in patients with BC.This historical cohort study was carried out using data from 522 participants with BC. Data were gathered from medical records of these patients admitted to Mahdieh Oncology Center of Hamadan Province, western Iran, from January 2000 to August 2011. Kaplan-Meier estimator was used to estimate the survival rates and, censored quantile regression (CQR) to provide in-depth insight in the multivariable association between prognosis factors and survival rates.Patients follow-up ranged from around 3 to 197 months. One-, three-, and five-year survival rates were 90%, 73% and 62.5%, respectively. Results of CQR model showed that change in the age at diagnosis, number of involved lymph nodes and tumor size could significantly change the median and some other quantiles of OS.This study, confirm the importance of early detection of BC and usefulness of CQR because of possible changes in distribution family of survival time.

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