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Kamran S.C.,Harvard Radiation Oncology Program
Cancer | Year: 2016

Radiation has long been associated with carcinogenesis. Nevertheless, it is an important part of multimodality therapy for many malignancies. It is critical to assess the risk of secondary malignant neoplasms (SMNs) after radiation treatment. The authors reviewed the literature with a focus on radiation and associated SMNs for primary hematologic, breast, gynecologic, and pediatric tumors. Radiation appeared to increase the risk of SMN in all of these; however, this risk was found to be associated with age, hormonal influences, chemotherapy use, environmental influences, genetic predisposition, infection, and immunosuppression. The risk also appears to be altered with modern radiotherapy techniques. Practitioners of all specialties who treat cancer survivors in follow-up should be aware of this potential risk. © 2016 American Cancer Society.

Hattangadi J.A.,Harvard Radiation Oncology Program | Hattangadi J.A.,Beth Israel Deaconess Medical Center | Hattangadi J.A.,University of Cincinnati | O'Reilly J.T.,Harvard Radiation Oncology Program | And 5 more authors.
Journal of Oncology Practice | Year: 2012

Although radiation therapy is highly safe and effective in treating cancer, recent reports of dangerous radiation-related errors have focused a national spotlight on the field of radiation oncology and, more specifically, on the rapidly evolving and complex nature of radiation devices and how they are regulated. The purpose of this review is to explore the issues involved in medical device regulation in radiation oncology. We start with a general review of federal medical device regulation, including explanations of the legal and regulatory framework, and then discuss issues specific to radiation oncology with real-world examples. Wealso provide our thoughts on potential solutions and reforms to the current system, including better reporting of radiation-related errors in a centralized database, well-defined criteria for establishing substantial equivalence of a new device, and standard postmarket surveillance of radiation devices. Modern radiation therapy is a powerful tool that can help cure many patients'cancers and alleviate others' suffering with limited adverse effects. We must ensure that this promise is never compromised by avoidable mistakes. Copyright © 2011 by American Society of Clinical Oncology.

News Article | March 2, 2017
Site: www.prweb.com

The recent 2017 Genitourinary Cancers Symposium in Orlando questioned whether the recommendations from the 2012 US Preventative Services Task Force (USPSTF) in regards to PSA screenings could have a negative impact for black men who already have higher rates of prostate cancer-related mortality and a later stage of prostate cancer diagnosis. “This has always been a grave concern of mine and that is one of the reasons why I was not in favor of the Task Force recommendation back in 2012,” stated Dr. David Samadi. “We have known for years that African American men represent a high-risk group for prostate cancer and yet are significantly less likely than other men to use early detection screening tools like prostate-specific antigen testing for prostate cancer.” The 2012 replaced the 2008 recommendation which had recommended against PSA-based screening for prostate cancer in men aged 75 or older and concluded that the evidence was insufficient to make a recommendation for younger men. Now the USPSTF recommends against PSA-based screening for prostate cancer in all age groups. Researchers from the Harvard Radiation Oncology Program in Boston compared the risks of prostate cancer metastasis and mortality by black and non-black race. The goal was to find out the outcomes for men before the USPSTF recommendations were made. In order to do this they used the Surveillance, Epidemiology, and End Results (SEER) database and looked at outcomes for 390,259 men diagnosed with prostate cancer between 2004 to 2011. Results showed black men were 65% more likely to be diagnosed with metastatic prostate cancer than non-black men with their risk of dying from the disease to be 36% higher. “I recommend for every man to get what we call a baseline PSA screening starting at age 40,” advised Dr. Samadi. “This has always been our first line of defense against prostate cancer and prostate diseases. It is not clear exactly why African American men have higher rates but what we do know is that this silent killer occurs less often in Asian-American and Hispanic men when compared to black men.” Another finding from this research was that there were significant interactions between race and PSA screening eligibility. Black men ages 55 to 69, who met the age criteria for PSA screening, had higher risk (76% vs 55%) and prostate cancer mortality (53% vs 25%) than ineligible patients. This finding led researchers to speculate that black men of screening age could be disproportionately and negatively impacted by the 2012 recommendations to end PSA screening. “This is not the findings we want to see and it is disappointing news,” exclaimed Dr. Samadi. “African American men have a 60-70% increased risk of prostate cancer over white men. Not only do they have the highest rate of new prostate cancer cases in the United States but they also have the highest proportion of aggressive prostate cancers. We need to work very hard on preventing black men from falling through the cracks.” Dr. Samadi went on to add, “Our best line of defense is the PSA screening test. Yes, it is true that with PSA screening you may over diagnose but over diagnosis should not lead to overtreatment. Every man I see is treated as an individual. All men should talk to their doctor to find out what’s best for them. Having a frank discussion with your doctor can help avoid unnecessary surgery which is why men should find a doctor who is an expert in prostate cancer. All urologists should encourage and make it easier for black men to be screened for this potentially deadly disease.” Patients newly diagnosed with prostate cancer can contact world renowned prostate cancer surgeon and urologic oncologist, Dr. David Samadi. For a free phone consultation and to learn more about prostate cancer risk, call 212-365-5000.

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