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Gaikar R.B.,Pravara Institute of Medical Sciences | Gadhave A.G.,P.A. College | Karate B.K.,Radhabai Kale Mahila Mahavidyalya
Indian Journal of Heterocyclic Chemistry | Year: 2012

3-Formylchromones 1 when treated with 2-(benzo[cf]isoxazol-3-yl) acetic acid 2 under microwave irradiation afforded 3-((E)-2-benzo[c/] isoxazol-3-yl) vinyl)-4H-chromen- 4-ones (3). Compounds 3 on treatment with thiourea gave the compound 5-(2- (benzo[d]isoxazol-3-yl) vinyl)-4(-2-hydroxypenyl) pyrimidine-2(1H)- Thiones 4. Compounds 3 on treatment with guanidine gave the compound 2-(5-(2- (benzol[dJisoxazol-3-yl)vinyl)-l,2-dihydro-2-iminopyrimidin-4- yl) phenols 5. Moleculer descriptor properties were analyzed by using simple moleculer descriptor used by "Lipinski's rule of 5". The structures of compounds were established on the basis of spectral data. Synthesized compounds were screened for their antimicrobial activities.


Takate S.J.,Commerce and Science College | Karale B.K.,Radhabai Kale Mahila Mahavidyalya | Salve S.P.,Commerce and Science College | Kale D.V.,Commerce and Science College | And 3 more authors.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2015

4-Chloro-3,5-dimethylphenol exhibits disinfectant properties. Its 1,3,4-thiadiazole and 1,2,4-triazole derivatives have been prepared. These novel compounds are characterized with the help of spectral techniques like IR, 1H NMR and mass spectrometry. These novel compounds have been screened in vitro for their antimicrobial activities. © 2015, American Board of Family Medicine. All rights reserved.


Karale B.K.,Radhabai Kale Mahila Mahavidyalya | Takate S.J.,Commerce and Science College | Salve S.P.,Commerce and Science College | Zaware B.H.,Commerce and Science College | Jadhav S.S.,Commerce and Science College
Oriental Journal of Chemistry | Year: 2015

A Claisen-Schimidt condensation of 2-hydroxyacetophenones 1a-f with an aldehyde 2 yielded a series of compounds 3a-f. Compounds 3a-f were transformed into series of substituted chromones 4a-f, pyrazolines 5a-f and aurones 6a-f on treatment with DMSO/I2, NH2NH2/EtOH and Hg(OAc)2/pyridine respectively. All these novel compounds were characterized by spectral techniques. All the compounds were screened for their antibacterial potential.


Karale B.K.,Radhabai Kale Mahila Mahavidyalya | Takate S.J.,Commerce and Science College | Salve S.P.,Commerce and Science College | Zaware B.H.,Commerce and Science College | Jadhav S.S.,Commerce and Science College
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2014

Reaction of acid hydrazide 1 with various aryl isothiocynates yields thiosemicarbazides 2. Compounds 2 gives 1,3,4-thiadiazoles 3 and 1,2,4-triazoles 4 in acidic and basic medium respectively. Newly synthesized compounds have been characterized by spectralmethods like IR, 1H NMR and mass spectrometry and screened for their antimicrobial activity.

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