Radhabai Kale Mahila Mahavidyalaya

Ahmadnagar, India

Radhabai Kale Mahila Mahavidyalaya

Ahmadnagar, India

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Dhokale N.T.,Ahmednagar College | Karale B.K.,Radhabai Kale Mahila Mahavidyalaya | Nagawade A.V.,Ahmednagar College
Asian Journal of Chemistry | Year: 2017

In the present investigation, a simple and efficient synthesis of Mn(II), Fe(II), Co(II) and Ni(II) complexes containing salicyloylpyrazole oxime moiety is reported. The synthesized complexes were characterized by elemental analysis and spectral techniques such as IR, NMR and UV-visible. The formation of complexes were also confirmed by thermal studies and molar conductance. The analytical data supports 1:2 stoichiometry for metal:ligand. The molar conductivity data indicated the non-electrolytic nature of complexes. The electronic absorption spectra suggested the square planar geometry for metal complexes. © 2017, Chemical Publishing Co. All rights reserved.


Dhokale N.T.,Ahmednagar College | Karale B.K.,Radhabai Kale Mahila Mahavidyalaya | Nagawade A.V.,Ahmednagar College
Oriental Journal of Chemistry | Year: 2017

Mn (II) and Fe(II) complexes with Schiff bases substituted salicyloyl pyrazole oximes were synthesized by the reaction of CFPHMP, FPHMP, DCFPHMP, CFPHMMP and BFPHMP (see introduction for definitions) with transition metal ion Manganese (Mn2+) and Iron (Fe2+). They were characterized by analytical and spectral methods. The elemental analysis data reveal that the Schiff base metal (II) complexes have 1:2 (M:L) stoichiometry. The molar conductivity data showed them to be non electrolytes. The Schiff bases are bidentate coordinating through the imine nitrogen and phenolic oxygen of salicyloyl pyrazole oximes. Based on analytical and spectral data, four-coordinate geometry is assigned for all complexes. The electronic absorption spectra suqqests the square planer geometry for the complexes. The ligand salicyloyl pyrazole oximes and their Mn (II) and Fe (II) complexes were screened against bacillus subtilis, Staphylococus aureus, actinomycetes and pseudomonas. © 2017, Oriental Scientific Publishing Company. All rights reserved.


Randhavane P.V.,P.A. College | Narwade S.K.,P.A. College | Saji G.,Nicholas Piramal India Ltd | Karale B.K.,Radhabai Kale Mahila Mahavidyalaya
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2010

Acid hydrazide 1 is treated with aryl isothiocyanates to get corresponding thiosemicarbazides 2. Compounds 2 in acidic medium give thiadiazoles 3 and in basic medium give triazoles 4. These compounds are synthesized by conventional method and ultra sound irradiation method. Some of the synthesized compounds are tested for their antimicrobial, antiviral and antioxidant activities.


Jadhav R.K.,Ssgm College | Nikumbh A.B.,Ssgm College | Karale B.K.,Radhabai Kale Mahila Mahavidyalaya
Oriental Journal of Chemistry | Year: 2015

A series of 3-Formylchromone 1 was reacted with 1-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine 2 to get (1-(4-(4-fluorophenyl)thiazol-2-yl)-1H-pyrazol-4-yl)(2-hydroxyphenyl) methanone 3 which on reaction with hydroxylamine hydrochloride given methanone oxime 4 and 4 on treatment with POCl3formed 2-(1-(4-(4-fluorophenyl)thiazol-2-yl)-1H-pyrazol-4-yl)benzo[d]oxazole 5. The structures of synthesized compounds were confirmed by spectral analysis further they were screened for their biological activity.


Gaikar R.B.,Pravara Institute of Medical Sciences | Gadhave A.G.,P.A. College | Karale B.K.,Radhabai Kale Mahila Mahavidyalaya
Indian Journal of Heterocyclic Chemistry | Year: 2010

1-(4-(Pyridin-2-yl) benzyl)-3-propyl-1W-pyrazol-5(4H)-one 1 was treated with heterocyclic aldehydes such as 2-chloro-3-formylquinoline 2,4-formylpyrazole 3 and 3- formylchromone 4, in acetic acid to get (4Z)-1 -(4-pyridin-2-yl) benzyl-4-((2-chloroquinolin- 3-yl) methylene)-3-propyl-1H- pyrazol-5(4H)-ones5, (4Z)-1-(4-(pyridin-2-yl) benzyl)-4-((1- phenyl-1H-pyrazol-4-yl) methylene)-3-propyl-1H-pyrazol-5(4H)-ones 6 and (4Z)-1-(4- (pyndin-2-yl) benzyl)-4-((4-oxo-4H-chromen-3-yl) methylene)-3-propyl- 1H-pyrazol-5(4H)- ones 7. These compounds were synthesized by conventional as well as by ultrasound irradiation. Synthesized compounds were characterized by 1H NMR, mass and IR spectral techniques. They were also screened for antimicrobial activity.


Karale B.K.,Radhabai Kale Mahila Mahavidyalaya | Nirmal P.R.,Radhabai Kale Mahila Mahavidyalaya | Akolkar H.N.,Radhabai Kale Mahila Mahavidyalaya
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2015

A series of novel thiadiazoles and triazoles anchored with benzimidazole have been synthesized and evaluated for their biological activities. © 2015, Scientific Publishers. All rights reserved.


Karale B.K.,Radhabai Kale Mahila Mahavidyalaya | Nirmal P.R.,Radhabai Kale Mahila Mahavidyalaya | Akolkar H.N.,Radhabai Kale Mahila Mahavidyalaya
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2015

Novel trifluoro pyrazolyl chromones and aurones containing thiophene moiety have been synthesized, characterized and screened for their antibacterial, antifungal, antiviral and antioxidant activities.


Akolkar H.N.,Radhabai Kale Mahila Mahavidyalaya | Karale B.K.,Radhabai Kale Mahila Mahavidyalaya
Oriental Journal of Chemistry | Year: 2015

3-Formylchromone 1 was treated with 1-(4-(4-bromophenyl)thiazol-2-yl)hydrazine 2 to get (1-(4-(4-bromophenyl)thiazol-2-yl)-1H-pyrazol-4-yl)(2-hydroxyphenyl)methanone --------(3-ae). Compound 3 on treatment with NH2OH/HCl gavethe compound 2-[(E)-{1-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(hydroxyimino)methyl]phenol (4a-e). Compound 4 on treatment with POCl3 gave 2-(1-(4-(4-bromophenyl)thiazol-2-yl)-1H-pyrazol-4-yl)benzo[d]oxazole (5a-e). The synthesized compounds have been characterized with the help of spectral techniques.


Karale B.K.,Radhabai Kale Mahila Mahavidyalaya | Gadhave A.G.,P.A. College
Indian Journal of Heterocyclic Chemistry | Year: 2010

The 1,3-Dipolar cycloaddition reaction is employed as a convenient and simple strategy to construct novel class of spiroisoxazolines having quinoline and pyrazole nucleus. The reaction takes place between methylene cyclopentane and aldoxime (nitrile oxide generated in situ), which serves as excellent 1,3-dipoles. The synthesized spiroisoxazoline derivatives (11-20) were characterized by IR, 1H NMR, Mass spectra and tested for their antibacterial activity.


PubMed | Radhabai Kale Mahila Mahavidyalaya and Commerce and Science College
Type: Journal Article | Journal: Indian journal of pharmaceutical sciences | Year: 2015

The reaction of 5-nitrobenzimidazolone with phenoxyethyl bromide in presence of potassium carbonate in dimethyl formamide obtained 6-nitro-1,3-bis(2-phenoxyethyl)-1,3-dihydro-2H-benzimidazol-2-one. It was reduced using stannous chloride to get 6-amino -1,3-bis(2-phenoxyethyl)-1, 3-dihydro-2H-benzimidazol -2-one, which was further treated with aromatic sulphonyl chloride to obtain benzimidazolone derivatives, 6a-k. These compounds were tested for antibacterial, antituberculosis and antifungal activity. Most of them have shown very good activity against some gram positive and gram negative microorganisms and fungal strains. Some of them have shown moderate activity against Mycobacterium tuberculosis.

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