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Jadhav R.K.,Ssgm College | Nikumbh A.B.,Ssgm College | Karale B.K.,Radhabai Kale Mahila Mahavidyalaya
Oriental Journal of Chemistry | Year: 2015

A series of 3-Formylchromone 1 was reacted with 1-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine 2 to get (1-(4-(4-fluorophenyl)thiazol-2-yl)-1H-pyrazol-4-yl)(2-hydroxyphenyl) methanone 3 which on reaction with hydroxylamine hydrochloride given methanone oxime 4 and 4 on treatment with POCl3formed 2-(1-(4-(4-fluorophenyl)thiazol-2-yl)-1H-pyrazol-4-yl)benzo[d]oxazole 5. The structures of synthesized compounds were confirmed by spectral analysis further they were screened for their biological activity. Source

Gadhave A.G.,P.A. College | Gaikar R.B.,Pravara Institute of Medical Sciences | Kuchekar S.R.,P.A. College | Karale B.K.,Radhabai Kale Mahila Mahavidyalaya
Journal of Heterocyclic Chemistry | Year: 2014

A series of novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene anchored 1,3,4-triazoles (8a-h) and 1,3,4-thiadiazoles (9a-i) were synthesized from thiosemicarbazide (7a-j). The structures of these newly synthesized compounds were confirmed on the basis of IR, 1H-NMR, mass spectral techniques, and elemental analysis. The in vitro antimicrobial screenings of the synthesized compounds were carried out against four bacterial pathogens, namely Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa and three fungal pathogens Candida albicans, Aspergillus niger and Aspergillus clavatus, using broth microdilution minimum inhibitory concentration method. The compounds 7d, 7j, 8a, 9a, 9b, and 9i exhibited promising antibacterial activity against the tested strains, whereas some compounds were found to be active against one of the tested bacterial strains. © 2014 HeteroCorporation. Source

Karale B.K.,Radhabai Kale Mahila Mahavidyalaya | Gadhave A.G.,P.A. College
Indian Journal of Heterocyclic Chemistry | Year: 2010

The 1,3-Dipolar cycloaddition reaction is employed as a convenient and simple strategy to construct novel class of spiroisoxazolines having quinoline and pyrazole nucleus. The reaction takes place between methylene cyclopentane and aldoxime (nitrile oxide generated in situ), which serves as excellent 1,3-dipoles. The synthesized spiroisoxazoline derivatives (11-20) were characterized by IR, 1H NMR, Mass spectra and tested for their antibacterial activity. Source

Gaikar R.B.,Pravara Institute of Medical Sciences | Gadhave A.G.,P.A. College | Karale B.K.,Radhabai Kale Mahila Mahavidyalaya
Indian Journal of Heterocyclic Chemistry | Year: 2010

1-(4-(Pyridin-2-yl) benzyl)-3-propyl-1W-pyrazol-5(4H)-one 1 was treated with heterocyclic aldehydes such as 2-chloro-3-formylquinoline 2,4-formylpyrazole 3 and 3- formylchromone 4, in acetic acid to get (4Z)-1 -(4-pyridin-2-yl) benzyl-4-((2-chloroquinolin- 3-yl) methylene)-3-propyl-1H- pyrazol-5(4H)-ones5, (4Z)-1-(4-(pyridin-2-yl) benzyl)-4-((1- phenyl-1H-pyrazol-4-yl) methylene)-3-propyl-1H-pyrazol-5(4H)-ones 6 and (4Z)-1-(4- (pyndin-2-yl) benzyl)-4-((4-oxo-4H-chromen-3-yl) methylene)-3-propyl- 1H-pyrazol-5(4H)- ones 7. These compounds were synthesized by conventional as well as by ultrasound irradiation. Synthesized compounds were characterized by 1H NMR, mass and IR spectral techniques. They were also screened for antimicrobial activity. Source

Randhavane P.V.,P.A. College | Narwade S.K.,P.A. College | Saji G.,Nicholas Piramal India Ltd | Karale B.K.,Radhabai Kale Mahila Mahavidyalaya
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2010

Acid hydrazide 1 is treated with aryl isothiocyanates to get corresponding thiosemicarbazides 2. Compounds 2 in acidic medium give thiadiazoles 3 and in basic medium give triazoles 4. These compounds are synthesized by conventional method and ultra sound irradiation method. Some of the synthesized compounds are tested for their antimicrobial, antiviral and antioxidant activities. Source

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