Radboud University Nijmegen is a public university with a strong focus on research located in Nijmegen, the Netherlands. Established since 17-10-1923 and situated in the oldest city of the Netherlands, it has seven faculties and enrolls over 19,130 students. Radboud was internationally ranked by QS World University Rankings, and placed at 136th. Wikipedia.
Brock R.,Radboud University Nijmegen
Bioconjugate Chemistry | Year: 2014
Over the past 20 years, cell-penetrating peptides (CPPs) have captured the attention of biomedical researchers, biophysicists, and (bio)organic chemists. These molecules efficiently enter cells and mediate entry of (macro)molecules that by themselves do not cross the plasma membrane. Since their discovery, models on the mechanism by which uptake occurs have seen major revisions. Starting from direct penetration across the plasma membrane, it later became apparent that for large molecular weight cargos in particular, endocytosis plays a role in uptake and furthermore that the route of uptake is a function of CPP, cell-type, cargo, and concentration. For the class of arginine-rich CPPs, this dependence on conditions has been elucidated in particular. As I will discuss here for this class of CPPs, a downside of this multitude of possibilities has been a lack of attention for commonalities in the observation of apparently distinct phenomena. At the same time, differences of apparently similar observations were not appreciated sufficiently. In addition, there has been insufficient acknowledgment of observations that are incompatible with the proposed models. Nevertheless, a considerable amount of data can be assembled into a quite coherent picture and the data that is left creates the basis for concrete future lines of research to resolve the questions that remain. Moreover, any uptake mechanism has its distinct structure-activity relationship for uptake giving room for the molecular design of molecules to preferentially direct uptake to either of them. © 2014 American Chemical Society.
Watt F.M.,Kings College London |
Huck W.T.S.,Radboud University Nijmegen
Nature Reviews Molecular Cell Biology | Year: 2013
The field of stem cells and regenerative medicine offers considerable promise as a means of delivering new treatments for a wide range of diseases. In order to maximize the effectiveness of cell-based therapies-whether stimulating expansion of endogenous cells or transplanting cells into patients-it is essential to understand the environmental (niche) signals that regulate stem cell behaviour. One of those signals is from the extracellular matrix (ECM). New technologies have offered insights into how stem cells sense signals from the ECM and how they respond to these signals at the molecular level, which ultimately regulate their fate. © 2013 Macmillan Publishers Limited. All rights reserved.
Kullberg B.J.,Radboud University Nijmegen |
Arendrup M.C.,Statens Serum Institute
New England Journal of Medicine | Year: 2015
Invasive candidiasis is the most common fungal disease among hospitalized patients in the developed world. Invasive candidiasis comprises both candidemia and deep-seated tissue candidiasis. Candidemia is generally viewed as the more common type of the disease, and it accounts for the majority of cases included in clinical trials. Deep-seated candidiasis arises from either hematogenous dissemination or direct inoculation of candida species to a sterile site, such as the peritoneal cavity (Fig. 1). Mortality among patients with invasive candidiasis is as high as 40%, even when patients receive antifungal therapy. In addition, the global shift in favor of nonalbicans candida species is troubling, as is the emerging resistance to antifungal drugs. During the past few years, new insights have substantially changed diagnostic and therapeutic strategies. Copyright © 2015 Massachusetts Medical Society. All rights reserved.
Hoogenboom R.,Radboud University Nijmegen
Angewandte Chemie - International Edition | Year: 2010
Chemical equation presentation. Branching out: Thiol-yne chemistry is emerging as new tool for polymer chemists, as it represents a unique and efficient coupling procedure to create highly branched structures (see scheme). This method can be used to prepare highly functional dendrimers and hyperbranched polymers. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA,.
Van Bokhoven H.,Radboud University Nijmegen
Annual Review of Genetics | Year: 2011
Mutations in more than 450 different genes have been associated with intellectual disability (ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this number will increase three to fourfold in the next years due to the rapid implementation of innovative high-throughput sequencing technology in genetics labs. Numerous functional relationships have been identified between the products of individual ID genes, and common molecular and cellular pathways onto which these networks converge are beginning to emerge. Prominent examples are genes involved in synaptic plasticity, Ras and Rho GTPase signaling, and epigenetic genes that encode modifiers of the chromatin structure. It thus seems that there might be common pathological patterns in ID, despite its bewildering genetic heterogeneity. These common pathways provide attractive opportunities for knowledge-based therapeutic interventions. © 2011 by Annual Reviews. All rights reserved.