Nijmegen, Netherlands

Radboud University Nijmegen
Nijmegen, Netherlands

Radboud University Nijmegen is a public university with a strong focus on research located in Nijmegen, the Netherlands. Established since 17-10-1923 and situated in the oldest city of the Netherlands, it has seven faculties and enrolls over 19,130 students. Radboud was internationally ranked by QS World University Rankings, and placed at 136th. Wikipedia.

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Radboud University Nijmegen | Date: 2017-07-19

The invention provides a method for the detection with SABRE magnetic resonance of an analyte at an unknown concentration Csub in a complex sample, the method comprising: (a) providing a series of mixtures M1, M2, , Mn, wherein each mixture comprises a predefined part of the complex sample comprising the analyte, a SABRE catalyst at a concentration Cm, and especially also a co-substrate at a concentration Cco-sub, wherein Csubmco-sub; and wherein two or more of the mixtures are provided with a known concentration of added analyte for standard addition determination of the unknown concentration of said analyte; and (b) applying p-H2 (para H2) to the mixtures and measuring with nuclear magnetic resonance the magnetic resonance response of the mixtures; and determining from the magnetic resonance response of the series of mixtures the unknown concentration of the analyte.

Radboud University Nijmegen and DSM IP Assets B.V. | Date: 2017-01-18

The invention is directed to a meniscus prosthesis comprising an arc-shaped meniscus prosthesis body having a main portion (1) comprising a reinforcing part (2) and two end portions (1A, 1B) comprising fixation parts (2A, 2B), wherein the main portion (1) comprises a part made of a first biocompatible, non- resorbable material extending between the two end portions (1A, 1B), wherein the reinforcing part (2) and the fixation parts (2A, 2B) are made of a second biocompatible, non-resorbable material and wherein the reinforcing part (2) extends between the fixation parts (2A, 2B) and wherein the fixation parts (2A, 2B) have a through hole (3A, 3B), the first biocompatible, non-resorbable material has a tensile modulus of at most 100 MPa as determined by ISO 527-1 and the second biocompatible, non-resorbable material has a tensile modulus of at least 01 MPa as determined by ISO 527-1.

Radboud University Nijmegen | Date: 2016-11-17

The present invention provides proteins/genes, which are essential for survival, and consequently, for virulence of Streptococcus pneumoniae in vivo, and thus are ideal vaccine candidates for a vaccine preparation against pneumococcal infection. Further, also antibodies against said protein(s) are included in the invention.

Radboud University Nijmegen | Date: 2017-09-13

The invention relates to a process for the preparation of beads comprising a biocompatible hydrophobic polymer, a perfluorocarbon and optionally a metal compound, comprising the steps of:a) adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture,b) adding the first liquid mixture to an aqueous solution of a biocompatible surfactant under sonication to obtain a second liquid mixture,c) maintaining the sonication of the second liquid mixture while cooling,d) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads comprising the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound,e) separating the beads from the suspension and preparing a water suspension of the beads andf) freeze-drying the water suspension to obtain the beads,wherein the addition of the first liquid mixture to the biocompatible surfactant in step b) is performed within a period of at most 10 seconds,wherein the sonication in step b) and the sonication in step c) are performed by a probe at an amplitude of at least 240 m for 1-10 minutes andwherein the weight ratio of the biocompatible surfactant to the biocompatible hydrophobic polymer is at least 3:1.

Fries P.,Ernst Strüngmann Institute (ESI) for Neuroscience | Fries P.,Radboud University Nijmegen
Neuron | Year: 2015

I propose that synchronization affects communication between neuronal groups. Gamma-band (30-90 Hz) synchronization modulates excitation rapidly enough that it escapes the following inhibition and activates postsynaptic neurons effectively. Synchronization also ensures that a presynaptic activation pattern arrives at postsynaptic neurons in a temporally coordinated manner. At a postsynaptic neuron, multiple presynaptic groups converge, e.g., representing different stimuli. If a stimulus is selected by attention, its neuronal representation shows stronger and higher-frequency gamma-band synchronization. Thereby, the attended stimulus representation selectively entrains postsynaptic neurons. The entrainment creates sequences of short excitation and longer inhibition that are coordinated between pre- and postsynaptic groups to transmit the attended representation and shut out competing inputs. The predominantly bottom-up-directed gamma-band influences are controlled by predominantly top-down-directed alpha-beta-band (8-20 Hz) influences. Attention itself samples stimuli at a 7-8 Hz theta rhythm. Thus, several rhythms and their interplay render neuronal communication effective, precise, and selective. © 2015 Elsevier Inc.

Cools R.,Radboud University Nijmegen
Current Opinion in Neurobiology | Year: 2011

Dopamine has long been implicated in a wide variety of high-level cognitive processes, ranging from working memory to rule learning and attention switching. Notable progress has been made in the past decades, but the mechanisms underlying effects of dopamine on high-level cognition remain unclear. This article reviews evidence for an important role of the striatum and its interaction with the prefrontal cortex and suggests a variety of ways by which changes in dopamine transmission can bias high-level cognition. © 2011 Elsevier Ltd.

Lamers L.P.,Radboud University Nijmegen
Biological reviews of the Cambridge Philosophical Society | Year: 2015

Fens represent a large array of ecosystem services, including the highest biodiversity found among wetlands, hydrological services, water purification and carbon sequestration. Land-use change and drainage has severely damaged or annihilated these services in many parts of North America and Europe; restoration plans are urgently needed at the landscape level. We review the major constraints on the restoration of rich fens and fen water bodies in agricultural areas in Europe and disturbed landscapes in North America: (i) habitat quality problems: drought, eutrophication, acidification, and toxicity, and (ii) recolonization problems: species pools, ecosystem fragmentation and connectivity, genetic variability, and invasive species; and here provide possible solutions. We discuss both positive and negative consequences of restoration measures, and their causes. The restoration of wetland ecosystem functioning and services has, for a long time, been based on a trial-and-error approach. By presenting research and practice on the restoration of rich fen ecosystems within agricultural areas, we demonstrate the importance of biogeochemical and ecological knowledge at different spatial scales for the management and restoration of biodiversity, water quality, carbon sequestration and other ecosystem services, especially in a changing climate. We define target processes that enable scientists, nature managers, water managers and policy makers to choose between different measures and to predict restoration prospects for different types of deteriorated fens and their starting conditions. © 2014 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.

Plichta M.M.,University of Mannheim | Scheres A.,Radboud University Nijmegen
Neuroscience and Biobehavioral Reviews | Year: 2014

A review of the existing functional magnetic resonance imaging (fMRI) studies on reward anticipation in patients with attention-deficit/hyperactivity disorder (ADHD) is provided. Meta-analysis showed a significant medium effect size (Cohen's d= 0.48-0.58) in terms of ventral-striatal (VS)-hyporesponsiveness in ADHD.Studies on VS-responsiveness and trait impulsivity in the healthy population demonstrate the opposite relationship, i.e. impulsivity-scores positively correlated with VS activation during reward processing.Against the background that ADHD may represent an extreme on a continuum of normal variability, the question arises as to how these contrasting findings can be integrated. We discuss three theoretical approaches, each of which integrates the opposing findings: (1) an inverted-u-shape model; (2) a (genetic) moderator model; and (3) the "unrelated model". We conclude that at the present stage the number of existing studies in the healthy population as well as in ADHD groups is too small for a final answer. Therefore, our presented integrative approaches should be understood as an attempt to frame future research directions by generating testable hypotheses and giving practical suggestions for future studies. © 2013 Elsevier Ltd.

Lisman J.E.,Brandeis University | Jensen O.,Radboud University Nijmegen
Neuron | Year: 2013

Theta and gamma frequency oscillations occur in the same brain regions and interact with each other, a process called cross-frequency coupling. Here, we review evidence for the following hypothesis: that the dual oscillations form a code for representing multiple items in an ordered way. This form of coding has been most clearly demonstrated in the hippocampus, where different spatial information is represented in different gamma subcycles of a theta cycle. Other experiments have tested the functional importance of oscillations and their coupling. These involve correlation of oscillatory properties with memory states, correlation with memory performance, and effects of disrupting oscillations on memory. Recent work suggests that this coding scheme coordinates communication between brain regions and is involved in sensory as well as memory processes

Van Bokhoven H.,Radboud University Nijmegen
Annual Review of Genetics | Year: 2011

Mutations in more than 450 different genes have been associated with intellectual disability (ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this number will increase three to fourfold in the next years due to the rapid implementation of innovative high-throughput sequencing technology in genetics labs. Numerous functional relationships have been identified between the products of individual ID genes, and common molecular and cellular pathways onto which these networks converge are beginning to emerge. Prominent examples are genes involved in synaptic plasticity, Ras and Rho GTPase signaling, and epigenetic genes that encode modifiers of the chromatin structure. It thus seems that there might be common pathological patterns in ID, despite its bewildering genetic heterogeneity. These common pathways provide attractive opportunities for knowledge-based therapeutic interventions. © 2011 by Annual Reviews. All rights reserved.

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